ORGN 295 |
| Metal-catalyzed C-N bond formations represent a crucial contribution to the synthetic methodologies for the preparation of nitrogen-containing compounds. While Cu-catalyzed C-N bond formations of aryl halides are a usual tool for cross-coupling reactions, it was only recently that extension of this chemistry to vinyl halides as substrates have been possible. Thus, an efficient copper-catalyzed coupling of readily accessible vinyl halides and primary amides is described herein. The resulting enamido-type products have shown to be very useful intermediates in the synthesis of highly substituted nitrogen-containing heterocyclic compounds, such as oxazoles, pyrroles and indole derivatives.
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Metal-Mediated Reactions and Syntheses
8:00 AM-12:00 PM, Monday, August 20, 2007 BCEC -- 254 A/B, Oral
Division of Organic Chemistry |
