BIOT 290 |
| Increasing cell culture densities and productivities are placing a larger burden on downstream clarification and purification operations due to increased solids mass and other impurities. To accommodate these challenges, innovative process techniques are needed that can facilitate the removal of process impurities and improve clarification performance. A method was developed that examines the effects of cell culture pH conditioning and predicts optimal conditions for cell culture clarification by microfiltration or centrifugation. Implementation of this method has led to improved impurity removal and increased clarification performance. |
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Poster Session
5:30 PM-7:30 PM, Wednesday, August 22, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Biochemical Technology |