ORGN 141 |
| The FR235222 structure represents a novel scaffold that targets human histone deacetylases (HDACs). HDACs regulate transcription of genes and represent a promising class of anticancer agents. HDACs are up-regulated in pancreatic cancers, and inhibiting these enzymes may lead to the control of cell growth. Thus, development of new structures that target HDACs may provide compounds that selectively target pancreatic cancer cells over normal cells. The synthesis of a series of FR235222 derivatives and the results of these compounds run in pancreatic cytotoxicity assays are described. |
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Total Synthesis, Materials, Devices and Switches, Molecular Recognition and Self-Assembly, Biologically-Related Molecules and Processes
8:00 PM-10:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Organic Chemistry |