PMSE 286 |
| The methotrexate containing cisplatin-like polymer was formed from the simple aqueous solution combination of methotrexate and tetrachloroplatinate. Two types of MS were run on the sample. EI MS allows the assignments of lower mass ion fragments whereas MALDI MS allows higher mass ion fragments to be generated. There is some overlap with similarity in the ion fragments created in this overlapped mass range. Higher mass F MALDI was run producing ion fragments to about 180,000 daltons. Fragmentation of the methotrexate moiety appears to occur only at the site of bond breakage. Must of this breakage occurs at the petidine, benzoyl, and glutamic acid moieties. This is expected since these sites are all single sigma bonds. |
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Joint PMSE/POLY Poster Session
6:00 PM-8:00 PM, Tuesday, August 21, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Polymeric Materials: Science & Engineering |