ORGN 987 |
| Enantioselective reactions catalyzed by organic molecules (asymmetric organocatalysis) “in water” or “in the presence of water” is an emerging area in asymmetric synthesis. Recently, we developed an organocatalyst for enantioselective aldol reaction.1 Later, we discovered that the same reaction becomes more facile if carried in the presence of aqueous medium. Thus, we are able to get more than 99% ee by using less than 1 mol % of the organocatalyst. In this talk, I will discuss these results. 1. M. Raj, V. Maya, S.K. Ginotra, and V.K. Singh, Org. Lett. 2006, 8, 4097. |
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Asymmetric Reactions and Syntheses
1:00 PM-5:00 PM, Thursday, August 23, 2007 BCEC -- 253A, Oral
Division of Organic Chemistry |