AGFD 133 |
| Introduction: The plants of Artocarpus species distribute over the tropical and subtropical regions and have been used as traditional folk medicine in Indonesia against inflammation and malarial fever. Prenylflavonoids from Artocarpus communis (A. communis) and A. heterophyllus revealed antiinflammatory, cytotoxic, antiplatelet, scavenger and antioxidant properties were reported. In particular, prenylflavonoids isolated from A. communis revealed significant antiplatelet effects. To study the structure¨Cantiplatelet activity relationship of various prenylflavonoids isolated from Artocarpus species, we have further investigated the constituents of the root bark of Formosan A. communis. Results: From the root bark of A. communis, we have isolated four new flavonoids, dihydroartomunoxanthone (1), artomunoisoxanthone (2), cyclocomunomethonol (3), and artomunoflavanone (4), along with three known compounds, artochamins B (5) and D, and cyclocommunol CC (6). In the present paper, the structure elucidation of these four new compounds, 1-4 and the antiplatelet effect of these additional constituents of A. communis on human PRP are reported. Discussion: The antiplatelet effects of 1-3, 5 and 6 on platelet aggregation induced by adrenaline in human PRP were studied. In adrenaline-induced platelet aggregation, compounds 1, 5 and 6 prevented secondary aggregation. It indicated that the antiplatelet effects of 1, 5 and 6 are probably mediated through the suppression of cyclooxygenese-1 (COX-1) activity and reduced thromboxane formation or owing to the inhibition of thromboxane synthase, leading to reduced thromboxane formation. It clearly indicated the prenylflavonoid, such as 1, 3, 5 and the above two compounds indicated stronger antiplatelet effect probably mediated through the suppression of COX-1 activity than that of dihydrobenzoxanthones, such as compound 1. |
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General Posters
1:00 PM-3:00 PM, Tuesday, August 21, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Agricultural & Food Chemistry |