Synthesis of metal clusters containing carbohydrate ligands and antitumor activity

INOR 687

Varattur D. Reddy, vreddy@kingsborough.edu1, Divya V. Dayal, ddayal@stuyhs.net2, MV. Ramana Reddy, rreddy@unix.temple.edu3, and Stephen C Cosenza, cosenza@temple.edu3. (1) Physical Sciences, Kingsborough Community College, 2001 Oriental Blvd, Brooklyn, NY 11235, (2) Stuyvesant High School, 345 Chambers Street, New York, New York, NY 10283, (3) Fels Institute for cancer Research, Temple University School of Medicine, 3307, North Broad Street, Philadelphia, PA 19140-5101
Mixed-metal clusters of ruthenium, palladium, and platinum containing carbohydrate ligands have been synthesized. These compounds are of interest in catalysis and anticancer agents. The anticancer activity of rutheniun clusters containing tribenzyl glucal and tribenzyl galactal on prostate and leukemia cancer cell lines have shown GI-50 values less than 50 micromols.
 

Organometallic Synthesis
7:00 PM-10:00 PM, Tuesday, August 21, 2007 BCEC -- Exhibit Hall - B2, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, August 20, 2007 BCEC -- Exhibit Hall - B2, Sci-Mix

Division of Inorganic Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007