| MEDI | Monday, March 26, 2007 | ||
8:00 PM-10:00 PM Hyatt Regency Chicago -- Riverside Center, Sci-Mix | |||
Sci-Mix | |||
| Sponsored by: | MEDI | ||
| Presiding: | David P. Rotella | ||
| 89 | 2-Substituted tetrahydrocarbazoles as potential therapeutic agents for human papillomavirus infection Leah D'Aurora Richardson, Kevin W. Brown, Robert Harvey, Kristjan S. Gudmundsson, Paul R. Sebahar, Phiroze Sethna | ||
| 73 | 3'-Fluoro-2', 3'-unsaturated carbocyclic nucleosides: Synthesis, anti-HIV activity and molecular modeling studies Jianing Wang, Yunho Jin, Kimberly L. Rapp, Raymond F. Schinazi, C. K. Chu | ||
| 186 | In silico design of effective inhibitors for α-tubulin Karthikeyan Diraviyam, David Sept | ||
| 118 | A novel series of low nM JAK2 selective inhibitors exhibit potent in vitro activities with favorable preclinical properties Chi-Ching Mak, Jianguo Cao, Chun P. Chow, Richard Fine, John Hood, Xinshan Kang, Boris Klebansky, Dan Lohse, Andrew McPherson, Glenn Noronha, Ved P. Pathak, Joel Renick, Richard Soll, Binqi Zeng | ||
| 189 | Advanced topics for use of RediSep® specialty media columns in flash chromatography Veronica D. Thomason, Vaughn Williams | ||
| 192 | Approaches to precision-guided nanoparticles: Focus on linker and targeting molecule design and synthesis Robert N. Hanson, J. Adam Hendricks, Kristen Bailey | ||
| 349 | Characterization of a catalytic ligand bridging metal ions in phosphodiesterases 4 and 5 by molecular dynamics simulations and hybrid quantum mechanical/molecular mechanical calculations Ying Xiong, Hai-Ting Lu, Chang-Guo Zhan | ||
| 44 | Chemical and antimicrobial properties of anise essential oil Ezekeil H. Hudson II, Brooke Woodard, Kristina Casmire, Fawzia Abdel-Rahman, Wenlou Zhang, Mahmoud A. Saleh | ||
| 35 | Cloning, expression, and characterization of a K. pneumoniae acetyltransferase involved in virulence Amy E. Zercher, Jennifer L. DuBois | ||
| 305 | CNI-1493 inhibits Aß production and prevents plaque formation in an animal model of Alzheimet's disease Yousef Al-Abed, Richard Dodel, Bayan Aljabari, Kathy Keyvani, Philippe Marambaud, Rakez Kayed, Charles G. Glabe, Nicole Goertz, Susanne Schnell, Michael Bacher | ||
| 198 | Conformational features of substituted cyclopropanes in drug-like molecules: A brief guide for medicinal chemists Daniel L. Cheney, Jennifer X. Qiao | ||
| 138 | Design and synthesis of PEG-containing CC-1065 analogs for targeted therapy of cancer Robert Y. Zhao, Dapeng Sun, Emily Cavanagh, Michael Miller, Barbara Leece, Hans Erickson, Rajeeva Singh, Yelena Kovtun, Victor Goldmacher, Ravi Chari | ||
| 59 | Design, synthesis and evaluation of 1-(D-ribityl)-1,7-dihydro-pyrazolo[3,4-d]pyrimidine-4,6-diones bearing alkyl phosphate substituents as inhibitors of lumazine synthase Yanlei Zhang, Adelbert Bacher, Markus Fisher, Boris Illarionov, Mark Cushman | ||
| 334 | Development of selective inhibitors of protein tyrosine phosphatases using combinatorial fluorogenic peptide substrates Sayantan Mitra, Amy M. Barrios | ||
| 378 | Discovery of orally active butyrolactam 11b-HSD1 inhibitors for the treatment of metabolic syndrome Vince S. C. Yeh, Ravi Kurukulasuriya, David Madar, Francis A. Kerdesky, Jeffrey J. Rohde, Marina Pliushchev, Steven Fung, Katina Monzon, William J. Chiou, Jiahong Wang, Deanne Stolarik, Hovis Imade, David W. A. Beno, Robin Shapiro, Victoria Knourek-Segel, Eugene N. Bush, Denise M. Wilcox, Phong Nguyen, Michael Brune, Peer B Jacobson, James T. Link | ||
| 66 | Discovery of potent and orally bioavailable CCR5 antagonists: Part I Robert G. Wei, Binglong Chen, Laura Dunning, Elena Ho, Stefan Jaroch, Wheeseong Lee, James Onuffer, Babu Subramanyam, Jun Shen, Jih-Lie Tseng, Bin Ye, Phillips Gary | ||
| 395 | Discovery of potent and selective VLA-1 antagonists for the treatment of inflammatory diseases: Modifications of B-ring portion of hit compound A-328282.0 Indrani Gunawardana, Mathew Yanik, Rui Xu, Scott C. Miller, Steve Boyd, Kevin Condroski, Mark L. Lupher Jr., Liming Sui, Irina C. Jacobson, Donald S. Staunton, Eugene D. Thorsett | ||
| 85 | Docking and 3-D-QSAR analysis of HCV NS5B RNA-dependent RNA polymerase inhibitors based on a common benzothiadiazine scaffold Srinivas Odde, Prasanna Sivaprakasam, Robert J. Doerksen | ||
| 99 | Drug-ability case study: Exploration of structural modifications and their impact on oral bioavailability of novel radio-sensitization agents (A): Z-(±)-2-(1-Benzylindole-3-yl-methylene)azabicyclo[2.2.2]octane-3-ol, (B): Z-(±)-2-(1-Benzylindole-3-yl-methylene)azabicyclo[2.2.2]octane-3-one and (C): Z-(±)-2-[1-(4-chlorobenzyl)indole-3-yl-methylene]azabicyclo[2.2.2]octane-3-ol Abeer M Al-Ghananeem, Zaineb Al-Beyati, Ahmad H Malkawi, Vijayakumar N Sonar, Michael Freeman, Peter A. Crooks | ||
| 369 | Dual interaction assay receptor-corepressor/receptor-coactivator binding Muthu Jeyakumar, Paul Webb, Thomas S. Scanlan, John A. Katzenellenbogen | ||
| 417 | Extraction and fractionation of polyphenols from chinese medicinal plant torreya grandis and their antioxidant activity against ferric reducing ability, DPPH and reducing power activity Muhammad Khalid Saeed IV, Yulin Deng, Rong-ji Dai | ||
| 311 | Fragment based lead generation approaches for inhibitors of beta-secretase: Development of a novel series of isocytosine-based inhibitors Jeffrey S. Albert, Philip D Edwards, Donald Andisik, James B Campbell, Miles S. Congreve, Robin Carr, Gianni Chessari, Fredrik Edfeldt, Rugter HA Folmer, Gerard M Koether, Karin Kolmodin, Christopher W. Murray, Lise-Lotte Olsson, Sahil Patel, Tony DeBeer | ||
| 328 | Full length zinc selective inhibitors of matrix metalloproteinase Faith E Jacobsen, Cesar Augusto F. de Oliveira, J Andrew McCammon, Seth M. Cohen | ||
| 180 | Paper Withdrawn | ||
| 372 | Paper Withdrawn | ||
| 146 | Insight into the structural requirements of farnesyltransferase inhibitors based on 3-D QSAR CoMFA and CoMSIA models Devendra Sharad Puntambekar, Rajani Giridhar, Mange Ram Yadav | ||
| 332 | Interactions of β-lactam antibiotics with proteases Pia M. Tschische, Kanchana Majumder, Sishi Tang, Ewa Poduch, Praveena Dixit, Lakshmi P. Kotra | ||
| 347 | Liposome mediated inhibition of carbonic anhydrase Joel A Kooren, Adekunle Elegbede, Manas Haldar, Sanku Mallik, D K Srivastava | ||
| 151 | Mutual prodrugs of all-trans retinoic acid and histone deacetylase inhibitors: Potent anticancer agents Lalji K. Gediya, Aakanksha Khandelwal, Jhalak Mehta, Puranik Purushottamachar, Vincent C. O. Njar | ||
| 304 | New aids for molecular chaperones in combating ß-amyloid formation Jason E. Gestwicki, Anjanette J. Turbiak | ||
| 27 | Novel diphenyl ethers: Design, docking studies and inhibition of enoyl ACP reductase from Plasmodium falciparum and Escherichia coli and their structure activity relationship Gyanendra Kumar, Manmohan Chhibber, Prasanna Parasuraman, Ramya T. N. Chakravarthy, Namita Surolia, Avadhesha Surolia | ||
| 425 | Novel local drug delivery utilizing 1,8-naphthalimide derivatives Patrick D. Youso, Ronald E. Utecht | ||
| 36 | Novel preparation of nanosilver particles for bacteriostat drug and antimicrobial test Hai Feng, Miao.D Wang, Zai.L Fu | ||
| 338 | Peptide libraries containing Phe analogs-reversible inhibitors of thrombin and potent inhibitors of platelets aggregation Cristina Clement, Anna Babinska, Janet Gonzalez, Manfred Philipp | ||
| 321 | Potent, selective pyrazine-based blockers of the Nav1.8 (PN3) sodium channel Marc J. C. Scanio, Lei Shi, Michael E. Kort, Irene Drizin, Robert J. Gregg, James B. Thomas, Robert N. Atkinson, Matthew S. Johnson, Brian E Marron, Mark L. Chapman, Dong Liu, Michael J. Krambis, Xin Su, Char-Chang Shieh, XuFeng Zhang, Gricelda Hernandez, Shailen Joshi, Prisca Honore, Kennan C. Marsh, Alison Knox, Stephen Werness, Douglas S. Krafte, Michael F. Jarvis, Connie R. Faltynek | ||
| 407 | Predictive model of the inhibition of CYP3A4 by selected natural compounds Sushma Thotakura, Jerry A. Darsey, Kun Wang, John T. Arnason, Cesar M. Compadre | ||
| 356 | Progress toward the development of synthetic transcriptional activators Ryan J. Casey, Brian B. Brennan, Caleb A. Bates, Anna K. Mapp | ||
| 366 | Pyrimidine core small molecule inhibitors of estrogen and androgen receptor-coactivator binding Alexander A. Parent, Jillian R. Gunther, Jaimin P. Amin, John A. Katzenellenbogen | ||
| 374 | Quantitation of estrogens in male plasma using liquid chromatography with an electrochemical detector Amy Kallmerten, Brittany Rowland, Mark Pomerantz, William Oh, James Glick | ||
| 430 | Screening of disulfide induced protein refolding intermediates by capillary isoelectric focusing Harsha P. Gunawardena, Judy Fredlin, Koen van der Drift, Kevin Wee | ||
| 159 | Semi-synthesis and biological activity studies of 16a-thio-camptothecins Gabriele Fontana, Cristian Samorì, Arturo Battaglia, Greta Varchi, Giovanni Luca Beretta, Franco Zunino, Giuseppe Bifulco, Ezio Bombardelli | ||
| 156 | Structure-activity relationships of conformationally-biased chimeric inhibitors of Hsp90 M. Kyle Hadden, Sandeep Apte, Brian S. J. Blagg | ||
| 53 | Structure-activity relationships of novel pyrimidine derivatives as Plasmodial ODCase inhibitors Angelica M. Bello, Ewa Poduch, Ian Crandall, Lianhu Wei, Kevin C Kain, Emil F. Pai, Lakshmi P. Kotra | ||
| 167 | Structure-based design and evaluation of peptide and peptido-mimetic antagonists of Survivin Steven A. Kawamoto | ||
| 433 | Surface-functionalizable drug-conjugated polymer nanoparticles via ring-opening metathesis polymerization DeeDee Smith, Paul J. Endres, Keith W. Macrenaris, Hao Cheng, Srikumar M. Raja, Timothy R. Holden, Paul A. Bertin, Clifton K-F Shen, Vimla Band, Hamid Band, Thomas J. Meade, SonBinh T. Nguyen | ||
| 162 | Synthesis and anticancer properties of novel pyranopyridones Jennifer D Bettale, Marcia A. Ogasawara, Madhuri Manpadi, Eerik M Elias, Snezna Rogelj, Scott T Shors, Pavel Yu. Uglinskii, Nikolai M Evdokimov, Igor V. Magedov, Alexander Kornienko | ||
| 113 | Synthesis and biological activity of 2-amino-4-substitutedanilino-6-substituted phenylmethyl pyrrolo[2,3-d]pyrimidines as inhibitors of multiple receptor tyrosine kinases Aleem Gangjee, Sonali Kurup, Michael Ihnat, Dixy Green | ||
| 373 | Synthesis and evaluation of 17-alpha-heteroarylvinyl estradiols as ligands for the estrogen receptor ligand binding domain (ER-LBD) Sandra Olmsted, Robert N. Hanson, Pakamas Tongcharoensirikul, Emmett McCaskill, Richard B. Hochberg, David C. Labaree | ||
| 103 | Synthesis and evaluation of carrier linked small molecules as targeted chemo and binary radiotherapeutic agents Venkata J Reddy, Venkatram R. Mereddy | ||
| 416 | Synthesis and evaluation of functionalized carboranes as potential anticancer agents A. Vijender Reddy, P. Vijay Kumar Reddy, Subash C. Jonnalagadda, Venkatram R. Mereddy | ||
| 360 | Synthesis and LXR activity of 4-(3-(phenylethynyl)phenyl quinolines John W. Ullrich, Robert L. Morris, Ponnal Nambi, Elaine Quinet, Liang Chen, Anita Halpern, Qiang-Yuan Liu, Dawn Savio, Michael Basso, Raymond Unwalla, Anna Wilhelmsson, Annika Goos Nilsson, Crina Ursu, Erik Arnelof, Johnny Sandberg, Christopher Enroth, Jay Wrobel | ||
| 397 | Paper Withdrawn | ||
| 408 | Synthesis of fluorinated dihydropyrazolo-pyrimidine derivatives as potential biologically active compounds Olugbeminiyi O. Fadeyi, Kendra Wash, Cosmas O. Okoro | ||
| 142 | Synthesis of isoprenoid bisphosphonate isomers and their impact on protein geranylgeranylation José S. Yu, Andrew J. Wiemer, Kimberly M. Lamb, Raymond J. Hohl, David F. Wiemer | ||
| 129 | Synthesis of sansalvamide A derivatives: Novel templates as potent antitumor agents Erinprit K. Singh, Rodrigo Rodriguez, Thomas J. Styers, Po-Shen Pan, Chung-Mao Pan, Suchitra Ravula, Stephanie Lapera, Julia Cajica, Joseph D. Brown, Emily Parry, Shelli McAlpine | ||
| 105 | Synthesis of [124I]Iodo-ABT-737, a PET imageable tracer for BCl-2 expression in tumors Dongmei Han, Liwei Guo, David S Maxwell, David J. Yang, Seok Tae Lim, Ismael Samudio, Michael Andreeff, William G. Bornmann, Juri G. Gelovani | ||
| 183 | Tandem enzymatic syntheses of TDP-deoxysugars and spinosyn analogs by in vitro recombination of natural product biosynthetic pathways Hsien-Tai Chiu, Yi-Lin Chen, Chih Chien Wu | ||
| 287 | The effect of anesthetic molecule binding on neuronal nicotinic and GABA receptor model dynamics, gating mechanisms and open receptor states Richard James Law, Felice C Lightstone | ||
| 288 | The mechanism of K+ ion pumping and double gating elucidated by simulations and mutagenesis experiments on the gastric H,K-ATPase Richard James Law, Keith Munson, George Sachs, Felice C Lightstone | ||
| 127 | Paper Withdrawn | ||
| 76 | Total synthesis of carbocyclic sinefungin Xueqiang Yin, Guo-xia Zhao, Stewart W. Schneller | ||
| 443 | Paper Withdrawn | ||
| 440 | Understanding the biosynthetic capability of marine cyanobacteria: Enzymatic study of the curacin A pathway Liangcai Gu, David Sherman | ||
Symposium Grid -- Division of Medicinal Chemistry -- Session Listing
The 233rd ACS National Meeting, Chicago, IL, March 25-29, 2007