Engineering complex bioelastomers for vascular and orthopaedic applications via non-complex chemistry

POLY 276

Guillermo A. Ameer, g-ameer@northwestern.edu, Biomedical Engineering, Northwestern University, 2145 Sheridan Road, Room E-310, Evanston, IL 60208
The development of bioengineering technologies that are based on polymer chemistry have the potential to revolutionize the medical field and significantly improve healthcare. In one example, the rapidly developing field of tissue engineering often makes use of polymeric scaffolds to help guide tissue formation or regeneration. There are interfacial and mechanical requirements for these scaffolds in order for them to fulfill their duty as temporary artificial extracellular matrices. We have been developing and characterizing a novel family of biodegradable polyester elastomers referred to as polydiol citrates. In addition we have been developing novel scaffold nano- and micro-architectures to understand wound healing and facilitate the generation of tissues such as blood vessels, ligament, bone, and cartilage. This presentation will describe the development of new citric acid-based biodegradable elastomers and composites thereof for use in tissue engineering with an emphasis on vascular and orthopaedic tissue engineering.