Pushing the boundaries of 3-D-QSAR

COMP 10

Richard D. Cramer, cramer@tripos.com, Tripos Inc, 1699 South Hanley Road, St. Louis, MO 63144
Considering the relatively accurate potency predictions that 3D-QSAR can afford, and the dramatically improved cost/benefit relationship that is promised by the use of topomer alignments in 3D-QSAR, it seems timely to renew exploration of these technologies' scope. Directions currently being investigated include trends in q2, r2, and especially predictivity; as a data set is systematically expanded, and the inclusion of classical descriptors such as logP and MR with the 3D-QSAR fields.