Recognition of duplex DNA by aminoglycoside dimers

CARB 98

Sunil Kumar, skumar@clemson.edu1, Hongjuan Xi, hxi@clemson.edu1, Meredith Newby, mnewby@clemson.edu2, and Dev P. Arya, dparya@clemson.edu1. (1) Department of Chemistry, Clemson University, Clemson, SC 29634, (2) Physics and Astronomy, Clemson University, Kinard Laboratory, Clemson, SC 29634
Amino glycosides have been shown to bind preferably to A-form nucleic acids. Contrary to neomycin, neomycin-neomycin dimers show extremely high affinity towards B-form DNA. Synthesis and development of novel aminoglycoside dimers, structural studies and thermodynamic analysis of binding of aminoglycsoide dimers to AT rich DNA sequences will be presented.

 

Nucleic Acid Therapeutics
9:00 AM-11:45 AM, Wednesday, March 28, 2007 McCormick Place North -- Room N226, Level 2, Oral

Division of Carbohydrate Chemistry

The 233rd ACS National Meeting, Chicago, IL, March 25-29, 2007