CARB 55 |
| The lipid A moiety of lipopolysaccharides (LPS) initiates innate immune responses resulting in the production of a wide range of cytokines. And the KDO residue of LPS has considerable impact on modulating immune responses. It is difficult to investigate how the KDO of LPS takes effect owing to the inherent heterogeneity of LPS and the difficult purification of natural specimens. Chemical synthesis can provide easy access to various structural congeners required for the structure – activity relationships. A convergent synthetic approach has been developed for synthesis of lipid A with KDO. This approach uses a highly functionalized trisaccharide building block that is selectively protected with a set of orthogonal protecting groups. The strategy was employed for the preparation of lipid A with KDO derived from N. meningitidis. The immune responses caused by the synthetic compound were compared to those of N. meningitidis lipid A. |
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General Posters
6:00 PM-8:00 PM, Tuesday, March 27, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Carbohydrate Chemistry |