Identifying RNA structural motifs recognized by kanamycin A

CARB 52

Jessica L. Childs-Disney, childsdj@canisius.edu, Department of Chemistry & Biochemistry, Canisius College, 2001 Main Street, Buffalo, NY 14208 and Matthew D. Disney, mddisney@buffalo.edu, Department of Chemistry, Center for Excellence in Bioinformatics & Life Sciences and Department of Chemistry, University at Buffalo, State University of New York at Buffalo, Buffalo, NY 14260.
RNA plays critical roles in many biological processes including catalysis of chemical reactions, regulation of translation and transcription, and encoding of protein. RNA is also a validated drug target though it has mainly been underutilized. The aminoglycosides are the most well studied RNA binding ligands that elicit their antibiotic effect by binding to the bacterial A-site. In order to understand small molecule-RNA interactions, we have identified a variety of RNA structural motifs that bind to the aminoglycoside kanamycin A. We also discuss potential structure-activity relationships.
 

General Posters
6:00 PM-8:00 PM, Tuesday, March 27, 2007 Hyatt Regency Chicago -- Riverside Center, Poster

Division of Carbohydrate Chemistry

The 233rd ACS National Meeting, Chicago, IL, March 25-29, 2007