CARB 96 |
| RNA plays critical roles in a variety of cellular processes and is therefore a good target for developing drugs or chemical probes of function. One advantage that RNA targets have over protein is that their secondary structures are predictable from sequence. These structures not only include information on the motifs that are present in a particular RNA but also information on the relative orientation of the motifs. We are developing a general set of rules for designing small molecules that target particular RNA secondary structure motifs as part of our long term goal of generating a chemical code for recognition of RNA. Information from these studies will eventually allow for the rational design of compounds targeting RNA provided information on its secondary structure is known. |
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Nucleic Acid Therapeutics
9:00 AM-11:45 AM, Wednesday, March 28, 2007 McCormick Place North -- Room N226, Level 2, Oral
Division of Carbohydrate Chemistry |