CARB 60 |
| Remarkable changes in cell-surface carbohydrates occur with tumor progression, which appears to be intimately associated with the dreaded state if metastasis. Thus, glycosidase inhibitors that can interfere in the biosynthesis of oligosaccharides are regarded as attractive leads for drug discovery for a wide range of diseases. However, it has been difficult to develop safe and selective glycosidase inhibitors. We report herein our approaches for the design and synthesis of selective mannosidase inhibitors based on feedback inhibition and specific protease hydrolysis. |
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General Posters
6:00 PM-8:00 PM, Tuesday, March 27, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Carbohydrate Chemistry |