CARB 45 |
| Neomycin has previously been shown to target A-form nucleic acids. Recent work by our group has also demonstrated the ability of neomycin to bind the B-DNA duplex, with binding constants in the 106 range, through dual recognition utilizing neomycin (a major groove binder) and a minor groove binder. DNA duplexes of GC rich content have been shown to exhibit A-form characteristics. Minor groove binding polyamindes provide a unique way to selectively target DNA duplexes of GC rich content through the introduction of imidazole monomeric units. These polyamides are capable of binding in the 107-109 range. Recent progress in the synthesis of a neomycin-polyamide conjugates containing pyrrole and imidazole monomers, specifically designed to target GC rich DNA duplexes in the subnanamolar binding range, will be presented.
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General Posters
6:00 PM-8:00 PM, Tuesday, March 27, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Carbohydrate Chemistry |
