CARB 44 |
| DNA:RNA hybrid structures are of significant interest due to the key role they play in a number of biological processes such as translation, reverse translation and the catalytic cycle of telomerase. However, few reported attempts have been made to target the unique structure of the DNA:RNA hybrid. Ethidium bromide, an intercalator, has been shown to specifically bind DNA:RNA hybrids when in competition with various nucleic acid structures. Our group has previously shown the unique ability of neomycin to bind nucleic acid structures of A-form conformation. Through the direct conjugation of neomycin to an ethidium bromide derivative, a novel neomycin conjugate has been developed to specifically target DNA:RNA hybrid, A-form, structures. Design, synthesis and thermodynamic binding characterization of a novel neomycin-methidium derivative capable of specifically targeting DNA:RNA hybrid structures will be presented.
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General Posters
6:00 PM-8:00 PM, Tuesday, March 27, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Carbohydrate Chemistry |
