CARB 115 |
| Glycosylphosphatidylinositols (GPIs) are a class of glycolipids which are expressed by all eukaryotic cells. These compounds play vital roles in many biological events through anchoring proteins and glycoproteins to cell membranes. Recently, we become interested in CD52 antigen, a GPI-anchored glycopeptides on human sperm and lymphocyte cells. To study the functions of GPI in CD52, we decided to synthesis the native GPI 1a, as well as its derivatives 1b-c. The functions of these GPIs will be examined to obtain the structure-activity relationship information. This presentation will describe in detail the synthesis of the target structures.
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Biological Applications of Carbohydrates
8:30 AM-12:10 PM, Thursday, March 29, 2007 McCormick Place North -- Room N226, Level 2, Oral
Division of Carbohydrate Chemistry |
