CHED 890 |
| Quorum Sensing is a chemical communication system in bacteria used to sense cell density through the synthesis, secretion and detection of signaling molecules called autoinducers (AI's). AI-2 is a furanone borate ester autoinducer linked to virulence in several pathogenic bacteria. Here we describe mechanism-based electrophilic inhibitors of the AI-2 synthase, LuxS. Inhibition of LuxS could prevent pathogenic behavior and be a new type of antibiotic. |
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Undergraduate Research Poster Session: Biochemistry
2:00 PM-4:00 PM, Monday, March 26, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Chemical Education |