INOR 790 |
| Cortisone is the inactive precursor molecule of the active hormone cortisol. It is activated through hydroxylation of the 11-keto-group by an enzyme. This study was designed to examine the interaction of cortisone with four metal ions (cadmium, lead, mercury, and zinc). The study was carried out at different pH values and metal ion/ligand concentrations. Infrared and Raman spectroscopes were used to determine the preferred site of coordination of metal ions. Upon complexation, the infrared and Raman spectra of cortisone at low pH showed a shift in frequency and a decrease in intensity of the C=O bands, suggesting that the coordination of metal ions in cortisone occurs through the O atom of the C=O groups at acidic pH. At higher pH, only zinc was found to interact strongly with cortisone. The relative stability constants for the binding of cortisone by metal ions were determined. The polymorphism of cortisone was also discussed. |
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Coordination Chemistry: Characterization and Application
7:00 PM-10:00 PM, Tuesday, March 27, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Sci-Mix
Division of Inorganic Chemistry |