INOR 217 |
| A Ni(II)-coordinated enediolate has been proposed as the O2 reactive species in the catalytic pathway of acireductone dioxygenase (ARD). This enzyme catalyzes a reaction that is a shunt out of the methionine salvage pathway in the bacterium Klebsiella ATCC 8724. Of relevance to this Ni(II) enediolate species, we have recently isolated and characterized a novel trinuclear Ni(II) enediolate complex of an acireductone model substrate. In this complex, two terminal six-coordinate Ni(II) centers are supported by a chelate ligand having a mixed hydrophobic/hydrogen bond donor secondary environment. The central Ni(II) in the trinuclear cation is square planar and binds two oxygen donors from each of two coordinated acireductone model substrates. The structural, spectroscopic, and O2 reactivity properties of this complex will be presented. |
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Structural, Functional and Biomimetic Modeling in Bioinorganic Chemistry
7:00 PM-10:00 PM, Sunday, March 25, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Sci-Mix
Division of Inorganic Chemistry |