Calcium oxalate monohydrate (COM) crystals were successfully templated on micron-patterned, self-assembled monolayers (SAMs) of w-functionalized alkanethiols on gold.  Factors governing mass transport of Ca²⁺ and C₂O₄^2- to the surface of the SAM were varied to assess their effect on COM nucleation.  The size (d) of the active growth regions varied from d = 10 to 30  (step 5) microns, while maintaining a constant spacing (p = d « 1.5). The spacing (p) between the active growth regions varied from p = 45 to 165 (step 30) microns, with a constant size of 15 microns. The crystalline interface of the active growth regions varied by both assembling the monolayers on different coinage metal substrates (Au, Ag, Cu) and synthesizing new amino acid terminated peptidyl-thiol monomers. The results of COM nucleation studies on these new templates and the greened synthesis of the peptidyl-thiol monomers are presented.