Chemistry of chromium(V): Biological significance-structure and reactivity of chromium (V)-glutathione complex

CHED 1188

Sheila M. Bernard, smahapat@regis.edu, Chemistry, Regis University, 3333 Regis Blvd., Denver, CO 80221 and Surendra N. Mahapatro, smahapat@regis.edu, Department of Chemistry, Regis University, 3333 Regis Blvd., Denver, CO 80221.
Reduction of chromate by intracellular reductants results in short-lived chromium(V) and chromium(IV) transients. The structure and reactivity of chromium(V) is central to the understanding of chromium toxicity. Ligand exchange at the chromium(V) center is a prerequisite for electron transfer. Any realistic model of chromium toxicity must also include glutathione (GSH). We are presently studying ligand exchange reactions of the Cr(V)-glutathione complex with physiologically important ligands such as citrate, picolinate, and hydroxyl carboxylic acids by EPR, ESI-MS, and rapid scanning UV-Vis spectrophotometry. We have investigated the role of second-order disproportionation of chromium(V).
 

Undergraduate Research Poster Session: Inorganic Chemistry
2:00 PM-4:00 PM, Monday, March 26, 2007 Hyatt Regency Chicago -- Riverside Center, Poster

Division of Chemical Education

The 233rd ACS National Meeting, Chicago, IL, March 25-29, 2007