CHED 905 |
| Diabetes mellitus is one of the leading causes of illness and death. Pancreatic beta cells produce insulin which helps regulate blood glucose levels. Insulin is required to activate insulin receptor substrate which in turn is responsible for activation of phosphotidyl inositol 3-kinase (PI3K). Vanadium has insulin enhancing activity and has long been used as a food supplement in diabetic patients. Similarly, falvanoids have also been shown to have antidiabetic properties. Individually, vanadium and flavonoids are known to exhibit the antidiabetic properties via the activation of PI3K. Whether vanadium-flavonoid complexes have additive or synergistic antidiabetic properties is being investigated. In this regard we have synthesized vanadium complexes with 3-hydroxy and 5-hydroxy flavone and characterized them. Induction/activation of PI3K by the above complexes is now being determined by RT-PCR, immunological, and fluorescence polarization techniques. |
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Undergraduate Research Poster Session: Biochemistry
2:00 PM-4:00 PM, Monday, March 26, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Chemical Education |