CHED 1223 |
| We are interested in designing ligands to mimic histidine and carboxylate residues in metalloenzymes. One approach is to use pyrazole rings tethered to a carboxylate group, however few studies have varied the length of the tether between these donor groups. By introducing additional CH2 groups between the pyrazoles and the carboxylate, we can systematically change the chelate ring size and investigate the effect this has on coordination complexes. Our group has devised an efficient route to the new bis(3-t-butyl-5-methyl-pyrazolyl)propionate ligand, which should create a seven membered chelate ring. Novel approaches to the organic synthesis of sterically bulky N,N,O ligands and our efforts to synthesize zinc complexes thereof will be discussed. |
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Undergraduate Research Poster Session: Inorganic Chemistry
2:00 PM-4:00 PM, Monday, March 26, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Chemical Education |