CHED 470 |
| Research on the structure and function of guanine-rich nucleic acids has shown that multiple guanine repeats in a sequence enable these biopolymers to adopt a quadruple helical structure known as G-DNA. In previous work, the DNA oligomer GGGGTTGGGG (Tet1.5) was used to create a self-assembling supramolecular G-DNA termed a G-wire, which was able to direct the positioning of gold nanoparticles. However, the linear scaffolds were previously deposited from bulk solvent and were randomly dispersed on a mica substrate. To achieve better localization and dictate initial orientation of G-wire self-assembly, in-situ self-assembly using a polymeric template was performed. Specifically, the polymer poly-5-norbornene-2-carboxylic acid with the oligonucleotide NH2-GGGGTTGGGG coupled at a ratio of 1 oligonucleotide to 10 carboxylic acid groups was synthesized to serve as a rigid polymeric template for the self-assembly of G-wires. Atomic Force Microscopy was used to characterize copolymer-templated self-assembly of G-wires on a mica substrate. |
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Undergraduate Research Poster Session: Nanotechnology
11:00 AM-1:00 PM, Monday, March 26, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Chemical Education |