Polypeptide cobalt complexes of beta-amino acids

CHED 914

Seth D. Westerman, sdwesterman07@aol.com1, Eva Csuhai, ecsuhai@transy.edu1, and Gerald L. Seebach2. (1) Division of Natural Sciences and Mathematics, Transylvania University, 300 N. Broadway, Lexington, KY 40508, (2) Division of Natural Science and Mathematics, Transylvania University, 300 N. Broadway, Lexington, KY 40508
In the last few years there has been a proliferation of research on β-amino acids and the polypeptides that they form. Since β-peptides appear to exhibit increased protease resistance, it is thought that this inactivity resistance might be due to the ability of the peptides to bind with metal cofactors. This research centers on the interaction of some simple α-amino acids, similar β-amino acids and some of their synthetic dipeptide derivatives and the ability to form complexes with Co and Ni at various pH. The complexes formed are followed through their UV-Vis and nmr spectra.
 

Undergraduate Research Poster Session: Biochemistry
2:00 PM-4:00 PM, Monday, March 26, 2007 Hyatt Regency Chicago -- Riverside Center, Poster

Division of Chemical Education

The 233rd ACS National Meeting, Chicago, IL, March 25-29, 2007