Attachment of tris(pyrazolyl)methane ligands to synthesis beads

CHED 526

Adam Phelan, wap05002@cub.uca.edu, Leah Thompson, Tiffany Linz, rtarkka@uca.edu, and Richard Tarkka, rtarkka@uca.edu. Department of Chemistry, University of Central Arkansas, 201 Donaghey Ave., Conway, AR 72035
Pyrazolylborates, and the isoelectronic pyrazolylmethanes, are versatile ligands known for more than 30 years. However, there are no reports to date of these ligands being attached to polystyrene synthesis beads for use as solid-phase materials. Our aims are as follows: functionalize a tris(pyrazoyl)methane ligand so that it can be attached to a PS synthesis bead; attach the ligand to a synthesis bead using standard peptide coupling techniques; derivatize the ligand with Ni(II); characterize the properties of the solid-phase ligand system and compare them to those of the ligand in solution. We will report our progress on this project to date.