Utility of dendrofullerene DF-1 nanoparticles for radioprotection in cells

CHED 497

Julia O'Bryan Reynolds, jreynold@centenary.edu1, Janice Huff2, Heidi Holtorf2, R. Kelley Bradley2, Antony S. Jeevarajan3, Valerie C. Moore, Valerie.Moore@uth.tmc.edu4, and Jodie L. Conyers, Jodie.L.Conyers@uth.tmc.edu5. (1) Department of Biophysics, Centenary College of Louisiana, 2911 Centenary Blvd., Shreveport, LA 71104, (2) Human Adaptations and Countermeasures Office, Johnson Space Center, 3600 Bay Area Blvd, Houston, TX 77096, (3) Biotechnology Program, Wyle Life Sciences, 1290 Hercules Drive, Suite 120, Mail Stop BT-37, Houston, TX 77058, (4) Department of Internal Medicine, University of Texas Health Science Center at Houston, 6770 Bertner Avenue THI C964A, Houston, TX 77030, (5) The University of Texas Health Science Center at Houston, 7000 Fannin Street, Houston, TX 77030
The development of atherosclerosis and other degenerative changes in the human cardiovascular system are known health consequences following exposure to ionizing radiation, and are thus a concern for astronaut health following long duration space flight. The goal of this project was to assess the ability of a C60-derivative, DF-1, to mitigate cellular damage resulting from low dose radiation exposure. DF-1 is a water soluble C60 fullerene encapsulated by dendrimeric functional groups and is proposed to exhibit antioxidant properties. We utilized human umbilical vein endothelial cells as a model system for study of the human vasculature. These cells were subjected to varying doses of X-ray irradiation in the presence and absence of DF-1, and the production of reactive oxygen species, secretion of pro-inflammatory markers, and cell viability were measured
 

Undergraduate Research Poster Session: Nanotechnology
11:00 AM-1:00 PM, Monday, March 26, 2007 Hyatt Regency Chicago -- Riverside Center, Poster

Division of Chemical Education

The 233rd ACS National Meeting, Chicago, IL, March 25-29, 2007