Development of peptidomimics as sensors for opiates

CHED 558

Tamara Binyon, lee_haven@yahoo.com1, Nick Gleason, sonofglea3@gmail.com1, Ashley Evans, ame03003@cub.uca.edu1, Rebekah Castleberry1, and Richard Tarkka2. (1) Department of Chemistry, The University of Central Arkansas, 201 Donaghey Ave, Conway, AR 72035, (2) Department of Chemistry, University of Central Arkansas, 201 Donaghey Ave, Conway, AR 72035
Peptide mimicry is being used as a strategy for developing an opiate sensor. The amino acids implicated in the binding of opiates in the rat u-opiod receptor are adjacent Asp(147)-Tyr(148) and Trp(318)-His(319) residues. Our strategy is to build a parallel combinatorial oligopeptide library, in which the 170 amino acid sequence that connects the four binding amino acids (in the native protein) is truncated to four residues. The library members will be screened for binding by exposure to a colored opiate derivative and looking for visible color changes in the library members. The status of this project will be reported.
 

Undergraduate Research Poster Session: Organic Chemistry
11:00 AM-1:00 PM, Monday, March 26, 2007 Hyatt Regency Chicago -- Riverside Center, Poster

Division of Chemical Education

The 233rd ACS National Meeting, Chicago, IL, March 25-29, 2007