CHED 1336 |
| Molecular libraries derived from an imidazole-4,5-dicarboxylic acid (I45DA) scaffold substituted with anilines and primary amines are described. This research is done in support of an overall project to deliver I45DA-based libraries to the NIH Molecular Library Screening Center Network (MLSCN). Comparable aniline-substituted I45DA derivatives have antiproliferative activity on HL-60 cells consistent with inhibition of cdk2. The final product compounds were synthesized in small, parallel syntheses. Each compound was purified by column chromatography before characterizing the material for identity by hydrogen NMR and LC-MS analysis with detection at 214 nm. The synthetic details and general characteristics of this compound class will be described. |
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Undergraduate Research Poster Session: Medicinal
2:00 PM-4:00 PM, Monday, March 26, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Chemical Education |