CHED 1303 |
| DNA base-pair mutations have been implicated in aging and cancer. 8-Oxo-2'-deoxyguanosine (OdG) is an abundant DNA lesion for which analogues have been developed and experimentally tested. In this work we have utilized the OPLSAA/GBSA(water) molecular mechanics method to analyze and compare the energetics of normal (dG:dC and dA:dT) and damaged (XdG(anti):dC and XdG(syn):dA where X=O, C, Cl, Br and I) base-pairs. A comparison of structural and geometrical differences and similarities will be presented. In addition, the structural and energetic effects of various base pairs will be examined using a model 10 unit DNA strand. |
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Undergraduate Research Poster Session: Medicinal
2:00 PM-4:00 PM, Monday, March 26, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Chemical Education |