Amino acid and fatty acid complexes of Re(CO)3+

CHED 1177

Anne de Greve, akdegreve@gmail.com1, Anil Cetin, ac30@uakron.edu1, Richard S. Herrick, rherrick@holycross.edu2, and Christopher J. Ziegler, ziegler@uakron.edu1. (1) Department of Chemistry, University of Akron, Akron, OH 44325-3601, (2) Department of Chemistry, College of the Holy Cross, 1 College St, Worcester, MA 01610
We are currently investigating the chemistry of the Re(CO)3+ fragment. This unit being used to model the chemistry of the 99mTc(CO)3+ core which has been proposed for use in biological imaging. The Re(CO)3+ unit is stable to aqueous solutions, and can be readily chelated by mutlidentate ligands. In this work, we are modifying amino acids and the fatty acid 12-aminododecanoic acid with 2-vinylpyridine to produce chelating ligands for Re(CO)3+. Both the ligands and resultant complexes were structurally characterized by single crystal X-ray methods. Each type of ligand can be used in developing new bifunctional chelating agents (BFCAs) either due to their intrinsic targeting ability, as in the fatty acid, or due to the ready ability to incorporate a targeting polypeptide.
 

Undergraduate Research Poster Session: Inorganic Chemistry
2:00 PM-4:00 PM, Monday, March 26, 2007 Hyatt Regency Chicago -- Riverside Center, Poster

Division of Chemical Education

The 233rd ACS National Meeting, Chicago, IL, March 25-29, 2007