Synthesis and antimicrobial activity of skeletally modified alpha pinene derivatives

CHED 1319

Preeti Dhar1, Teresa Snyder-Leiby2, Daniel Tzvi Cohen, dharp@newpaltz.edu1, and Pui Yee Chan, dharp@newpaltz.edu1. (1) Department of Chemistry, SUNY New Paltz, 75 South Manheim Boulevard, CSB 101, New Paltz, NY 12561, (2) Department of Biology, State University of New York, New Paltz, 75 S Manheim Blvd., CSB 101, New paltz, NY 12561
a-pinene, a known antimicrobial compound, is a rigid bicyclic monoterpene with a double bond that allows for a variety of functional and skeletal transformations. Testing and comparing the antimicrobial activity of each of the a-pinene derivatives obtained by either skeletal or functional group transformations, with a-pinene can help us better understand how the structure of a-pinene affects its antimicrobial activity. Earlier work from our lab focused on the functional group modification of a-pinene. Of all the groups tested, introduction of -OH, -NH2 and halogens (-Br,-Cl) were found to increase the antimicrobial activity the most. We have now synthesized a-pinene derivatives with altered carbon skeleton. These derivatives have been tested for their antimicrobial potential using TLC bio-autographic assays. The results of this study would be presented
 

Undergraduate Research Poster Session: Medicinal
2:00 PM-4:00 PM, Monday, March 26, 2007 Hyatt Regency Chicago -- Riverside Center, Poster

Division of Chemical Education

The 233rd ACS National Meeting, Chicago, IL, March 25-29, 2007