Surface modification of G4 and G5 PAMAM dendrimers

CHED 487

Craig D. Girten, girtenc1@nku.edu1, Jody R. Helton1, Donald A. Tomalia2, Kristi L. Haik, martines@nku.edu3, Heather A. Bullen, bullenh1@nku.edu1, and Keith A. Walters, walterske@nku.edu1. (1) Department of Chemistry, Northern Kentucky University, Highland Heights, KY 41099, (2) Dendritic NanoTechnologies, Inc, 2625 Denison Drive, Mount Pleasant, MI 48858, (3) Department of Biological Sciences, Northern Kentucky University, Nunn Dr, Highland Heights, KY 41099
The goal of the collaborative dendrimer project at Northern Kentucky University is to synthesize dendrimers capable of crossing the blood-brain barrier for drug delivery. This aspect of the research has focused on dual-functionalizing fourth and fifth-generation poly(amino)amide (PAMAM) dendrimers with the dansyl chloride fluorophore. The dual-functionalization will ultimately allow for dendrimers to have both fluorescent tags and moieties of interest (e.g., drugs) for future in vitro and in vivo studies.
 

Undergraduate Research Poster Session: Nanotechnology
11:00 AM-1:00 PM, Monday, March 26, 2007 Hyatt Regency Chicago -- Riverside Center, Poster

Division of Chemical Education

The 233rd ACS National Meeting, Chicago, IL, March 25-29, 2007