CHED 1191 |
| Adsorption of proteins at surfaces is of great importance in a number of applications, including surface-based bioassays, biosensors, and biomedical devices such as implants. Surfaces such as silicon, diamond, and amorphous carbon are commonly used during the development of these devices and are tailored such that they present functional groups which specifically bind to proteins of interest, while rejecting all others. We have investigated the adsorption of albumin and fibrinogen on amorphous carbon surface functionalized with molecular monolayers that present ethylene glycol (EG) or amine groups. The competitive nonspecific binding of these two proteins on functionalized amorphous carbon surfaces was monitored by fluorescence scanning. We find that the amount of albumin and fibrinogen binding to surfaces can be selectively controlled by functionalizing them using EG6 or EG6 and TFAAD monolayers. These results show promise for use of amorphous carbon surfaces in many potential applications, particularly in the development of biomedical implants. |
|
Undergraduate Research Poster Session: Inorganic Chemistry
2:00 PM-4:00 PM, Monday, March 26, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Chemical Education |