CHED 1314 |
| Glycinamide ribonucleotide formyltransferase (GARFT) catalyses the reaction between 10-formyl-5,6,7,8-tetrahydrofolic acid and glycinamide ribionucleotide (GAR) to give N-formylglycinamide ribonucleotide (FGAR). The formyl carbon of FGAR is destined to become the C-8 carbon atom of inosine monophosphate from which all purine nucleotides are derived. Consequently, GARFT is an attractive target site for anticancer chemotherapy. We have designed a series of pyrimido[4,5-e][1,4]diazepine-based folates as potential inhibitors of GARFT. We will report on our progress on developing synthetic methodology to access the pyrimidodiazepine heterocyclic system and our targets. |
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Undergraduate Research Poster Session: Medicinal
2:00 PM-4:00 PM, Monday, March 26, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Chemical Education |