Computational studies of a series of 1-phenyl isatin thiosemicarbazone and semicarbazone compounds

CHED 1375

Kyle B. Ford, kbford21@tntech.edu and Scott H. Northrup. Department of Chemistry, Tennessee Technological University, Box 5055, Cookeville, TN 38505
This work will present the structural analysis of a series of recently synthesized 1-phenyl isatin semicarbazones and thiosemicarbazones. Isatin compounds are important for their biological and antiviral properties. A manual conformational search was performed using the AM1 semi-empirical quantum method. Several key low energy structures were then further optimized and characterized using ab initio methods. In particular, proton and 13C-NMR shifts were calculated and favorably compared to experimental values.