CHED 1321 |
| Growth hormone releasing hormone (GHRH) is one of a family of hormones including glucagon, glucagon like peptide 1, parathyroid hormone and calcitonin. Structurally it can be characterized by having an N-terminal head group domain and a C-terminal helical tail. In an effort to explore a minimal sequence for activity, a head group was taken and extended into the tail region by adding one residue at a time until minimal bioactivity was observed. Upon addition of a sixth residue (Head-AYRKVL-NH2) sub-µM GHRH receptor affinity was observed. To explore the sequence specificity of binding, sixteen hexapeptide tails with various amino acid substitutions were synthesized in the context of a common head group (Head-AXXXXX-NH2). |
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Undergraduate Research Poster Session: Medicinal
2:00 PM-4:00 PM, Monday, March 26, 2007 Hyatt Regency Chicago -- Riverside Center, Poster
Division of Chemical Education |