MEDITuesday, 12 September 2006

1:30 PM-5:00 PM Moscone Center -- Room 102, Oral
Gamma and Beta Secretase
Sponsored by Biotage
Organizers:Andrew W. Stamford
Wenge Zhong
1:30 PMIntroductory Remarks
1:35 PMSecretases as therapeutic targets in Alzheimer's disease
Martin Citron
2:05 PMCyclic sulfonamides as γ-secretase inhibitors for the treatment of Alzheimer's disease
Dmitri Pissarnitski, Zhiqiang Zhao, Theodros Asberom, Thomas Bara, John W. Clader, William J. Greenlee, Henry Guzik, Lynn Hyde, Hubert Josien, Wei Li, Eric M. Parker, Murali Rajagopalan, Lili Zhang, Amin Nomeir
2:40 PMDesign and synthesis of potent gamma secretase inhibitors for the disease-modifying treatment of Alzheimer's Disease
Boyd L. Harrison, Anthony Kreft, Asaf Alimardanov, Madeline Antane, Suzan Aschmies, Kevin Atchison, David Casebier, Michael Chlenov, Derek C. Cole, Thomas Comery, George Diamantidis, John W. Ellingboe, Kristi Fan, Cathleen Gonzalez, Diane B. Hauze, Yun Hu, Donna Huryn, Uday Jain, Mei Jin, Dennis Kubrak, Kristina Kutterer, Melissa Lin, Peimin Lu, Joseph Lundquist, Charles Mann, Robert Martone, Scott C. Mayer, William J. Moore, Aram Oganesian, Alex Porte, Lynn Resnick, David Riddell, June Sonnenberg-Reines, Joseph R. Stock, Shaiu-Ching Sun, Eric Wagner, Zhang Wang, Kevin Woller, Zheng Xu, Margaret Zaleska, Minsheng Zhang, Hua Zhou, J. Steven Jacobsen
3:15 PMStructure-based design of potent and highly selective memapsin 2 (BACE) inhibitors
Arun K. Ghosh
3:50 PMDesign of an efficacious class of BACE inhibitors
Hsiu-Chiung Yang, Javier Agejas, David M Bender, Howard Broughton, Ana Belen Bueno, Robert Dally, Timothy Durham, Jon A. Erickson, Juan Espinosa, Rosario Gonzalaz, Patric Hahn, Debra Laigle, Todd Kohn, Patrick C. May, Juan Ramon Rodriguez, Gema Sanz, Timothy A. Shepherd, David Timm, Paloma Vidal, James R. McCarthy
4:25 PMDiscovery of 2,6-isonicotinamide beta-secretase inhibitors bearing a primary amine as an aspartate ligand
Shaun R. Stauffer

Symposium Grid -- Division of Medicinal Chemistry -- Session Listing

Symposium Grid -- Drug Discovery -- Session Listing

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006