Session: Structure-Based Design & Development of Estrogen Receptor Modulators


COMP		Sunday, 10 September 2006

9:00 AM-12:35 PM Moscone Center -- Room 224/226, Oral
Structure-Based Design & Development of Estrogen Receptor Modulators

Organizers:	Veerabahu Shanmugasundaram Neil Raheja
9:00 AM		Introductory Remarks
9:05 AM	4	Estrogen receptor structure Roderick E Hubbard
9:40 AM	5	Structural basis of estrogen receptor partial agonist and SERM agonist activities Kendall W. Nettles, Hai-Bing Zhou, John A. Katzenellenbogen, Geoffrey L. Greene
10:15 AM	6	Binding mode switching between ERalpha and ERbeta as the basis of subtype selectivity Yong Wang, Sherry Y. Guo, Jim D. Durbin, Amechand Boodhoo, D. Bruce Baldwin, Yue-wei Qian, Bryan H. Norman, Timothy I. Richardson, Gregory Durst, Venkatesh Krishnan, Jeff Dodge
10:50 AM	7	Structural insights into SERM design Felix F. Vajdos
11:25 AM	8	Computational characterization and prediction of estrogen receptor coactivator binding inhibitors Brian J. Bennion, Kristen S. Kulp, Jennifer L Montgomery, Felice C. Lightstone, Mark G. Knize, L. Michelle Bennett, James S. Felton
12:00 PM	9	Luck be a lady tonight: Generation of a new SERM template from an Estrogen Related Receptor Gamma (ERRg) program Aaron B. Miller, Adwoa Akwabi-Ameyaw, Jing Fang, David Gray, Dennis Heyer, Subba R. Katamreddy, Kevin Madauss, Lisa A. Orband-Miller, Wendy Y. Mills, Frank Navas III, Robert T. Nolte, Rosemary Sasse, Terrence L. Smalley Jr., Liping Wang, Shawn Williams, William J. Zuercher

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