| MEDI | Wednesday, 13 September 2006 | ||
7:00 PM-9:00 PM Moscone Center -- Hall D, Poster | |||
General Poster Session | |||
| Sponsored by Nature Reviews Drug Discovery | |||
| Organizer: | David P. Rotella | ||
| 325 | Chemoenzymatic synthesis of (R)-Nifenalol via yeast-mediated symmetric reduction of ketones Jian-He Xu, Wei Yang | ||
| 326 | De Novo design and synthesis of novel RNA polymerase inhibitors as potential anti-tuberculosis agents Anil K. Agarwal, Julian G. Hurdle, Amer I. AlOmar, Ian Chopra, A Peter Johnson, Colin W. G. Fishwick | ||
| 327 | Pyrrolidine carboxamide as novel class inhibitor of enoyl acyl carrier protein reductase from Mycobacterium tuberculosis (InhA) Xin He, Alian Akram, Robert Stroud, Paul R. Ortiz de Montellano | ||
| 328 | Benzothienoquinolines, N-10 bioisosteres of cryptolepine as novel antiifectives with lower cytotoxicity Seth Y. Ablordeppey, Xue Y. Zhu, Melissa Jacob, Shabana I. Khan, Larry A. Walker | ||
| 329 | Phenylimidazole and 4-pyridone hybrid derivatives as novel inhibitors of bacterial enoyl-ACP reductases FabI and FabK Hideo Kitagawa, Tomohiro Ozawa, Sho Takahata, Maiko Iida, Jun Saito, Takashi Watanabe, Eiki Shitara | ||
| 330 | Application of regioselective Staudinger reaction: Expedient synthesis and antibacterial evaluation of novel aminoglycoside antibiotics related to butirosin and amikacin Jie Li, Hsiao-Nung Chen, Cheng-Wei T. Chang | ||
| 331 | Studies towards synthesis and medicinal applications of antibiotic Ficellomycin Gang Chen, Andrei K Yudin | ||
| 332 | Discovery and SAR of diphenylborinic acid picolinate esters as a potent antibacterial and anti-inflammatory agent for the treatment of skin diseases Tsutomu Akama, Stephen J. Baker, Yong-Kang Zhang, Vittorio Sauro, Rajeshwar Singh, Kirk Maples, Jacob J. Plattner, Stephen J. Benkovic, Ving Lee | ||
| 333 | Optimization of pharmacokinetic properties of pyrazolopyrimidinediones, selective inhibitors of Helicobacter pylori Pamela J. Hill, Gregory S. Basarab, Abdullah Rastagar, Peter Webborn | ||
| 334 | Synthesis and biological activity study of potent inhibitors against aminoglycoside N-6' acetyltransferase: An important antibiotic resistance enzyme Feng Gao, Xuxu Yan, Karine Auclair | ||
| 335 | CYP3A4 inhibitory studies on a new series of macrolides Dahua Pan, Wenzhong Liang, Zhaohai Zhu, Scott G. Franzblau | ||
| 336 | 2,6-Hexadecadiynoic acid and 2,6-nonadecadiynoic acid: Novel synthesized acetylenic fatty acids as potent antifungal agents Néstor M. Carballeira, David Sanabria, Keykavous Parang | ||
| 337 | Antibacterial agents from multivalent design of antimicrobial peptides and combinatorial library screening Zhigang Liu, Chunhui Zhou, Anne Young, Heather Deshazer, Amanda Rice, Neville R Kallenbach | ||
| 338 | Surfactant-free nanoparticles for delivering antibiotics Julio Cesar Garay, Kerriann Robyn Greenhalgh, Edward Turos | ||
| 339 | Novel polyacrylamide nanoparticles for delivery of N-thiolated β-lactam antibiotics Yang Helen Wang, Kerriann Robyn Greenhalgh, Edward Turos | ||
| 340 | Heterosubstituted N-thiolated beta lactam antibiotics Praveen Ramaraju, Timothy E. Long, Edward Turos | ||
| 341 | 1,2-Dioxolanes as carbon isosteres of antimalarial 1,2,4-trioxolanes: Effects on chemical stability and antimalarial activity Xiaofang Wang, Yuxiang Dong, Sergio Wittlin, Jonathan L. Vennerstrom | ||
| 342 | Peterson olefination tool for synthesis of three new azasterols. Possible inhibitors of the Delta-(24,25) sterol methyl transferase Gonzalo G Visbal, Luis Corredor | ||
| 343 | Formation of primary and secondary carbon-centered radicals in the iron (II)-mediated decomposition of antimalarial 1,2,4,5-tetraoxanes Yuxiang Dong, Jonathan L. Vennerstrom | ||
| 344 | Structure-based design and synthesis of conformationally constrained inhibitors of parasitic cysteine proteases Yen Ting Chen, Ricardo Lira, Jason J. Reddick, Elizabeth Hansell, James H. McKerrow, William R. Roush | ||
| 345 | Peptidyl vinyl sulfonyl inhibitors of cysteine protease: Development and biologically activity Michael H. Ober, Yen Ting Chen, Elizabeth Hansell, James H. McKerrow, William R. Roush | ||
| 346 | Investigation of the antimicrobial properties of polycationic carbohydrate derivatives Marie Thomas, Alejandra Castano, Laura Friedman, Heidi Lee, Jay Leb, Leah Rothman, Karin Melkonian, Robert Engel | ||
| 347 | Phosphoramidate pronucleotides: A comparison of the phosphoramidase substrate specificity of human and E. coli histidine triad nucleotide binding proteins (hint) Tsui-Fen Chou, Janina Baraniak, Xin Zhou, Carston R. Wagner | ||
| 348 | Synthesis and evaluation of novel bisphosphonates targeting Undecaprenyl diphosphate synthase Rong Cao, Yonghui Zhang, Fenglin Yin, Michael Hudock, Rey-ting Guo, Andrew H-J. Wang, Eric Oldfield | ||
| 349 | Activity of 6-O-substituted macrolides against Mycobacterium tuberculosis Zhaohai Zhu, Valentina Z. Petukhova, Dahua Pan, Baojie Wan, Yuehong Wang, Olga Krasnykh, Gengli Yu, Kate Schellinger, Scott G. Franzblau | ||
| 350 | Bypassing antibiotic resistance: Development of novel pronucleotides as antibacterials Mallinath B. Hadimani, Andrew M. Lee, Scott F Singleton | ||
| 351 | Synthesis of phosphorous-containing folate and methotrexate analogs as potential inhibitors of dihydrofolate synthetase and antimalarial drugs Yonghong Yang, James K. Coward | ||
| 352 | Design, synthesis and broad antiparasitic activity of potent triclabendazole-sulfoxide bioisosteres Gabriel Navarrete-Vazquez, Alicia Hernandez-Campos, Francisco Hernandez-Luis, Lilián Yépez-Mulia, Rafael Castillo | ||
| 353 | Synthesis and antiamoebic activity of new ferrocene-metronidazole analogs against Entamoeba histolytica Shailendra Singh, Neelam Bharti, Amir Azam | ||
| 354 | Evaluation of metal-chloroquine derivatives in the inhibition of β-Hematin formation Maribel Navarro, William Castro | ||
| 355 | Discovery of high affinity peptide ligand for Vancomycin Nianhuan Yao, Kit S. Lam | ||
| 356 | Probing the structures of leishmanial farnesyl pyrophosphate synthases: Homology modeling and docking studies Prasenjit Mukherjee, Prashant V. Desai, Anuradha Srivastava, Mitchell A. Avery, Babu L. Tekwani | ||
| 357 | Synthesis and antiprotozoal activity of methyl (1-methyl-1H-benzimidazol-2-yl)carbamate derivatives Rafael Castillo, Antonio Hernández, Francisco Hernandez-Luis, Lilián Yépez-Mulia, Fernanda Frausto-Castorena, Alicia Hernandez-Campos | ||
| 358 | Paper Withdrawn | ||
| 359 | Sulfonamide hydroxamic acid anthrax lethal factor inhibitors: Improved selectivity over MMPs Seongjin Kim, Christopher Bayne, Melissa Nagata, Minda Yamaga, Lynne Cregar, Linda McKasson, Sean O'Malley, Sherri Mills, Mark Goldman, Cho Tang | ||
| 360 | Inhibitors of tryptophanyl-tRNA synthetase from Plasmodium falciparum via in situ click chemistry Suresh M. Pitram, Zhanna Druzina, Valery V. Fokin, Paul Schimmel, K. Barry Sharpless | ||
| 361 | Synthesis and antiprotozoal activity of nitrothiazole-benzimidazole hybrid carboxamides Olivia Soria-Arteche, Alicia Hernandez-Campos, Francisco Hernandez-Luis, Ivone Rosas-Martínez, Lilián Yépez-Mulia, Rafael Castillo | ||
| 362 | Synthesis and SAR for linker in tethered dimer inhibitors of NAD synthetase Wayne J. Brouillette, Liyuan Mou, Christie G. Brouillette, Chi-Hao Luan, Lawrence J. DeLucas | ||
| 363 | Design and synthesis of a novel nanomolar inhibitor of Toxoplasma gondii dihydrofolate reductase, its salt form and analogs Aleem Gangjee, Xin Lin, Lisa R. Biondo, Sherry F. Queener | ||
| 364 | Investigating the interaction between protozoan DNA-binding protein, JBP-1 and glycosylated DNA Rajesh K. Grover, Stephanie J. Pond, Mariceli Puga, Prem S. Subramaniam, Charles Weissmann, Piet Borst, David P. Millar, Paul Wentworth Jr. | ||
| 365 | Drug discovery targeted the GHKL superfamily Xinshan Kang, Boris Klebansky, Richard Fine | ||
| 366 | Synthesis and SAR studies of potent imidazopyridine anticoccidial agents Xiaoxia Qian, Gui-Bai Liang, Danqing D. Feng, Michael H. Fisher, Chris Brown, Anne Gurnett, Penny Leavitt, Paul Liberator, Andrew Misura, Samantha Samaras, Tamas Tamas, Dennis M. Schamtz, M. J. Wyvratt, Tesfaye Biftu | ||
| 367 | Molecular modeling of some 1H-benzimidazole derivatives with antiamoebic activity: A comparative molecular field analysis study Fabian López-Vallejo, José Luis Medina-Franco, Sergio Rodríguez-Morales, Alicia Hernández-Campos, Francisco Hernández-Luis, Lilián Yépez-Mulia, Rafael Castillo | ||
| 368 | Systematic investigation of the effect of sidechain basicity and length on the antimalarial activity of 7-chloroquinolines Kimberly S. Yearick, John N. Alumasa, Jayakumar K. Natarajan, Paul Roepe, Christian Wolf | ||
| 369 | pH-dependent metal ion binding studies on Dapson Hadijatu Mumini, Nsoki Phambu, Baibai Kamara | ||
| 370 | Development of new anti-malarial drugs derived from chloroquine Kekeli Ekoue-kovi, John, N Alumasa, Jayakumar K. Natarajan, Paul D. Roepe, Christian Wolf, Kimberly, S Yearick | ||
| 371 | Synthesis and evaluation of mechanism-based inhibitors of plasmepsin II Deepak Gupta, Patrick M. Woster | ||
| 372 | Structure-activity relationships for a series of inhibitors of purine nucleoside phosphorylase from Schistosoma mansoni Adriano D. Andricopulo, Glaucius Oliva, Marcelo S. Castilho, Marcela F. Terni, Richard C. Garratt, Matheus P. Postigo | ||
| 373 | Potent and orally active GSK-3 inhibitors Leyi Gong, Claudia Tan, Don Hirschfeld, Heather Hogg, Gary Peltz, Andrew Grupe, Zafrira Avnur, Pete Dunten | ||
| 374 | Discovery of selective JNK1 inhibitors Hanna Cho, Songyuan Shi, Shumeye Mamo, Wayne Spevak, Shenghua Shi, Hu Pan, Abhinav Kumar, Billy Lam, Brian West, Catherine Luu, Chao Zhang, Daniel Fong, Gaston Habits, Gideon Bollag, John Cantwell, Julie Rice, Kam Zhang, Kevin Eng, Rafe Shellooe, Rick Artis, Yong-Liang Zhu, Yoshihisa Suzuki, Prabha Ibrahim | ||
| 375 | Structure-activity relationship of sterol mimetic (1) analogs: Potent LXR agonists to upregulate ABCA1 gene expression Robert H. Jiang, Matthew M. Abelman, Bindu Joshi, Jeffrey Chisholm, Jia Hao, Nancy Chu, Nevena Mollova, Kwan Leung, Jeff A. Zablocki | ||
| 376 | Towards the design, synthesis and evaluation of novel RAR ligands Shyam Desai, Weilin Sun, Zhenping Zhang, Jerome L. Gabriel, Dianne Soprano, Daniel J. Canney | ||
| 377 | Indanylacetic acids carrying 4-thiazolyl/oxazolyl-phenyl tail groups, a new class of balanced PPAR alpha/gamma/delta triple agonists: Synthesis, SAR and in vivo efficacy Joachim Rudolph, Libing Chen, Dyuti Majumdar, William H. Bullock, Michael Burns, Soongyu Choi, Thomas Claus, Fernando E. Dela Cruz, Michelle Daly, Frederick J. Ehrgott, Jeffrey S. Johnson, James N. Livingston, Michelle Nophsker, Robert W. Schoenleber, Jeffrey Shapiro, Susan Tomlinson, Christopher Town, Ling Yang, Manami Tsutsumi, Xin Ma | ||
| 378 | Indanylacetic acid derivatives carrying aryl-pyridyl and aryl-pyrimidinyl tail groups: A new class of PPAR gamma/delta and PPAR alpha/gamma/delta agonists Louis-David Cantin, Sidney Liang, Herbert Ogutu, Christiana I. Iwuagwu, William H. Bullock, Michael Burns, Roger Clark, Thomas Claus, Fernando E. dela Cruz, Michelle Daly, Frederick J. Ehrgott, Jeffrey S. Johnson, James N. Livingston, Michelle Nophsker, Robert W. Schoenleber, Jeffrey Shapiro, Christopher Town, Ling Yang, Manami Tsutsumi, Xin Ma | ||
| 379 | Indole acetic acid derivatives incorporating [(thiazolyl/oxazolyl)-phenoxy/pyridyloxy] tail groups – novel, potent PPAR alpha/gamma/delta triple agonists: Synthesis, SAR, and in vivo efficacy Xin Ma, Martin Hentemann, Joachim Rudolph, William H. Bullock, Michael Burns, Louis-David Cantin, Libing Chen, Soongyu Choi, Roger Clark, Thomas Claus, Fernando E. Dela Cruz, Michelle Daly, Frederick J. Ehrgott, Christiana I. Iwuagwu, Jeffrey S. Johnson, Ellalahewage Kumarasinghe, Rico Lavoie, Sidney Liang, James N. Livingston, Dyuti Majumdar, Michelle Nophsker, Herbert Ogutu, Robert W. Schoenleber, Jeffrey Shapiro, Kanwar Sidhu, Christopher Town, Susan Tomlinson, Philip L. Wickens, Ling Yang, Zhonghua Zhang, Manami Tsutsumi | ||
| 380 | Sulfonylureas as partial PPAR gamma agonists Hiroo Koyama, Daniel J. Miller, Peter T. Meinke, Joel P. Berger, Thomas W. Doebber, David E. Moller, Soumya P. Sahoo | ||
| 381 | Design, synthesis and biological evaluation of novel PPAR a/g dual agonists Nam-Jung Kim, Seung-Mann Paek, Hwa-Young Yun, Bon Woong Koo, Youn-Hee Nam, Young-Ger Suh | ||
| 382 | Design and synthesis of 3-{4-[3-(2-aryl-2-yl-phenoxy)butoxy]-phenyl}propionic acids: A new class of dual PPAR&gamma/&delta agonists Isabel C. Gonzalez, Jason Lamar, Fatima Iradier, Yanping Xu, Leonard Winneroski, Jeremy York, Nathan Yumibe, Richard Zink, Chahrzad Montrose-Rafizadeh, Gary Etgen, Carolyn Broderick, Brian Oldham, Nathan B. Mantlo | ||
| 383 | Design and synthesis of novel and potent amide linked PPAR gamma/delta dual agonists Qing Shi, Emily J. Canada, Yanping Xu, Garret J. Etgen, Alan Warshawsky, Carol L. Broderick, Cathleen K. Clutinger, Lynnie A. Irwin, Michael E. Laurila, Chahrzad Montrose-Rafizadeh, Brian A. Oldham, Minmin Wang, Leonard L. Winneroski, Chaoyu Xie, Jeremy S. York, Nathan P. Yumibe, Richard W. Zink, Nathan B. Mantlo | ||
| 384 | Identification of highly potent and subtype-selective PPARalpha agonists as efficacious lipid modulating agents Guo Q. Shi, Yong Zhang, James F. Dropinslki, Soumya P. Sahoo, Jeol P. Berger, Taro E. Akiyama, Gaochao Zhou, Raul Alvaro, Tian-quan Cai, Peter T. Meinke | ||
| 385 | Toward PPAR agonists as novel therapeutics for inflammation and CNS disorders Upasana Mehra, Jack J. Lin, Gaston Habets, Prabha N. Ibrahim, Rick Artis, Chao Zhang | ||
| 386 | Synthesis and LXR activity of 3-[substituted phenyl] quinolines John W. Ullrich, Robert L. Morris, Ronald C. Bernotas, David Kaufman, Ponnal Nambi, Elaine Quinet, Liang Chen, Anita Halpern, Qiang-Yuan Liu, Dawn Savio, Mike Basso, Ray J Unwalla, Anna Wilhelmsson, Annika Goos Nilsson, Crina Ursu, Erik Arnelof, Johnny Sandberg, Christopher Enroth, Jay Wrobel | ||
| 387 | Exploration of the S4 binding element in amino acid-derived fXa inhibitors via parallel synthesis Jothirajah Marimuthu, Nickolay Y Chirgadze, Trelia J. Craft, Ronald S Foster, Jeffry B. Franciskovich, Larry L. Froelich, Peter R. Guzzo, Valentine J. Klimkowski, Jeffery K. Kyle, Michael J. Mayer, Donetta S. Gifford-Moore, Christopher W. Murray, John W. Liebeschuetz, John J. Masters, Jeffrey K. Smallwood, Gerald F. Smith, Sarah M. Smith, Richard D. Towner, Stephen C. Young, Michael R. Wiley | ||
| 388 | Synthesis of potent, selective and neutral inhibitors of FXa Ulf E. Fahlander, Kenneth L. Granberg, Emma Bratt, Kristina Nilsson, Jens Petersen, Yantao Chen, Ingemar Nilsson, Leifeng Cheng, Kosrat Amin, Kevin Foote, John W Rayner, Johan Broddefalk, Saswati Ghosal, Björn Holm, Johan Sundell, Johanna Deinum, Margareta Elg, Daniel Hovdal | ||
| 389 | Paper Withdrawn | ||
| 390 | Unusual alkylation of pyridazinone in FXa inhibitors Emma Bratt, Kenneth L. Granberg, Johanna Deinum | ||
| 391 | Optimization of piperazinone derivatives as FXa inhibitors Kenneth L. Granberg, Emma Bratt, Ulf E. Fahlander, Ingemar Nilsson, Kosrat Amin, Björn Holm, Huascar Villanueva, Christer Alstermark, Jens Petersen, Johanna Deinum, Margareta Elg, Ann-Charlotte Egnell, Daniel Hovdal | ||
| 392 | Balancing properties of FXa inhibitors Ulf E. Fahlander, Kenneth L. Granberg, Kosrat Amin, Emma Bratt, Christer Alstermark, Jens Petersen, Ingemar Nilsson, Kristina Nilsson, Fredrik Zetterberg, Saswati Ghosal, Björn Holm, Johan Broddefalk, Leifeng Cheng, Kevin Foote, John W Rayner, Johanna Deinum, Margareta Elg, Daniel Hovdal, Ann-Charlotte Egnell | ||
| 393 | Synthesis and SAR of 1,2-cis cyclic diamide-based inhibitors of coagulation factor Xa Jennifer X. Qiao, Tammy Wang, Sarah R. King, Gren Z Wang, Changhwan Chang, Daniel L. Cheney, Alan Rendina, Kan He, Joseph M. Luettgen, Robert M. Knabb, Ruth Wexler, Patrick Y. S. Lam | ||
| 394 | Structure-activity relationships of anthranilamide-based factor Xa inhibitors containing piperidinone and pyridinone P4 moieties James R. Corte, Tianan Fang, Donald J. P. Pinto, Wei Han, Zilun Hu, Xiang-Jun Jiang, Yun-Long Li, Alan R. Rendina, Joseph M. Luettgen, Pancras C. Wong, Kan He, Chong-Hwan Chang, Daniel L. Cheney, Robert M. Knabb, Ruth R. Wexler, Patrick Y. S. Lam, Jolicia F. Gauuan, Mark Hadden, Darren Orton | ||
| 395 | Aminomethyl pyrrolidine as a novel scaffold for FXa inhibitors Yan Shi, Jing Zhang, Philip D. Stein, Ying Wang, Lawrence J. Kennedy, Stephen P. O'Connor, Saleem Ahmad, Wei Han, Zilun Hu, Doree Sitkoff, Patrick Y. S. Lam, Karnail Atwal, Jeff A. Robl, Eddie C-K. Liu, Karen S. Hartl, Steven M. Seiler, Ruth R. Wexler, Robert Zahler | ||
| 396 | Synthesis of muraglitazar 12-carboxylic acid metabolite Yande Huang, Donglu Zhang, Venkatapuram Palaniswamy | ||
| 397 | 3-Phosphinoylpropionic acid inhibitors of Thrombin Activatable Fibrinolysis Inhibitor (TAFI) 1: Design, synthesis and biological activity Kumar Emayan, Shendong Yuan, Imadul Islam, Paul M. Hrvatin, Christopher West, Zheng Chang, Judi Bryant, Kieu Chu, Drew Sukovich, Brad O. Buckman | ||
| 398 | 3-Phosphinoylpropionic acid inhibitors of Thrombin Activatable Fibrinolysis Inhibitor (TAFI) 2: In vitro and in vivo evaluation Shendong Yuan, Kumar Emayan, Imadul Islam, Paul M. Hrvatin, Christopher West, Zheng Chang, Judi Bryant, Kieu Chu, Drew Sukovich, John Morser, Bill Dole, Mariko Nagashima, Ron Vergona, Kathy White, Jim Wang, Valdeci DaCunha, John Vincelette, Kohichi Kawai, Lei Zhao, Brad O. Buckman | ||
| 399 | 3-Phosphinoylpropionic acid inhibitors of Thrombin Activatable Fibrinolysis Inhibitor (TAFI) 3: Crystal structure of 3-phosphinoylpropionic acid inhibitors bound to carboxypeptidase B Marc Adler, Marc Whitlow, Shendong Yuan, Kumar Emayan, Imadul Islam, Paul M. Hrvatin, Christopher West, Zheng Chang, Judi Bryant, Brent Larson, Brad O. Buckman | ||
| 400 | Hit to lead discovery of potent 11b-HSD1 inhibitors Ravi Kurukulasuriya, Vince S. C. Yeh, William J. Chiou, Steven Fung, Jiahong Wang, Hing L. Sham, James T. Link | ||
| 401 | Discovery of anilinothiazolone analogs as 11beta-HSD1 inhibitors Chester Yuan, David J. St. Jean Jr., Qingyian Liu, Lynn Cai, Aiwen Li, Nianhe Han, Ben Askew, Randall Hungate, Lars Johansson, Lars Tedenborg, David Pyring, Meredith Williams, Minghan Wang, Clarence Hale, Jiandong Zhang, Steven Jordan, Michael Bartberger, Yaxiong Sun, Maurice Emery, Christopher H. Fotsch | ||
| 402 | Discovery of potent and selective 11ß-HSD-1 inhibitors Jyoti R. Patel, Qi Shuai, Jurgen Dinges, Martin Winn, Marina Pliushchev, Steven Fung, Katina Monzon, Jiahong Wang, William J. Chiou, Liping Pan, Kenton Longenecker, Hing L. Sham, Peer Jacobson, J. T. Link | ||
| 403 | Discovery and SAR of novel 11ß-hydroxysteroid dehydrogenase type I inhibitors Qi Shuai, Jyoti R. Patel, Jeffrey J. Rohde, Marina Pliushchev, Jurgen Dinges, Steven Fung, Katina Monzon, Jiahong Wang, Liping Pan, Hing L. Sham, Peer Jacobson, J. T. Link | ||
| 404 | SAR studies on a novel series of potent ACC2 inhibitors for treatment of obesity and type 2 diabetes Tianyuan Zhang, Richard F. Clark, Todd M. Hansen, Zhili Xin, Gang Liu, Xiaojun Wang, Rongqi Wang, Heidi S. Camp, Bruce A. Beutel, Hing L. Sham, Yu Gui Gu | ||
| 405 | Tetrahydroquinolines as novel cannabinoid-1 receptor antagonists Chongqing Sun, Doree Sitkoff, Yanting Huang, Yan Zhou, Zhengxiang Gu, Natesan Murugesan, Liya Kang, Yifan Yang, RoseAnn Baska, Mary Jane Cullen, MaryAnn Pelleymounter, Paul Stetsko, Olafur Gudmunsson, Oliver Flint, Susan Johngher, Steven Wu, Kamelia Behnia, Kenneth Carlson, William R. Ewing | ||
| 406 | Design, SAR and in vivo evaluation of 5-HT2C receptor agonists for the treatment of obesity Dean A. Wacker, Jeffrey G. Varnes, Keith J. Miller, Thao Ung, Ginger Wu, Chen-Pin Hung, Sarah Malmstrom, Ge Zhang, Eva Otanyi, William J. Keim, Mary Jane Cullen, Kenneth W. Rohrbach, Qu Qinling, Rangaraj Narayanan, Karen Rossi, Mary Ann Pelleymounter, Jeffrey A. Robl | ||
| 407 | Design and synthesis of potent and selective 5-HT2c receptor agonists Guohua Zhao, Chet Y. Kwon, Sharon N. Bisaha, Philip D. Stein, Chen-Pin Hung, Ginger Wu, Thao Ung, Xueying Cao, Keith J. Miller, Sarah Malmstrom, Ge Zhang, Eva Otanyi, William J. Keim, Mary Jane Cullen, Kenneth W. Rohrbach, Jinping Gan, Mary Ann Pelleymounter, Jeffrey A. Robl | ||
| 408 | Synthesis and biological evaluation of dihydroquinazolinones as potent and selective 5-HT2C receptor agonists Saleem Ahmad, Khehyong Ngu, Keith Miller, Ginger Wu, Chen-pin Hung, Sarah Malmstrom, Ge Zhang, Eva Otanyi, William J. Keim, Mary Jane Cullen, Kenneth W. Rohrbach, Michael Thomas, Jinping Gan, Rangaraj Narayanan, Mary Ann Pelleymounter, Jeffrey Robl | ||
| 409 | The synthesis and SAR of MC4R agonists for the treatment of obesity Iyassu K. Sebhat, Yingjie Lai, Khaled Barakat, Rui Tang, Rubana N. Kalyani, Aurawan Vongs, Tanya MacNeil, David H. Weinberg, Tung M. Fong, Lex Van der Ploeg, Arthur A. Patchett, Matthew J. Wyvratt, Ravi P. Nargund | ||
| 410 | Microwave assisted synthesis of thiazolo-, isothiazolo-, imidazolo-, and pyrimido-pyrimidinones as novel MCH1R antagonists Rui Zhang, Rachael C. Hunter, Tao Guo | ||
| 411 | Design and synthesis of orally efficacious piperidine-based melanin-concentrating hormone receptor 1 antagonists Wen-Lian Wu, Duane A Burnett, Mary Ann Caplen, Martin S Domalski, Chad Bennett, Richard Spring, Li Qiang, Thavalakulamgara K Sasikumar, William J Greenlee, Brian E Hawes, Kim O'Neill, Blair Weig, Brian Spar, Daniel Weston, Timothy Kowalski | ||
| 412 | Regioisomeric bicyclo[3.1.0]hexyl urea MCH-R1 antagonists: Addressing the fragmentation issues of bicyclohexyl ureas Mark D. McBriar, Ruo Xu, John W. Clader, Brian E. Hawes, Kim O'Neill, Daniel Weston, Kathleen Cox | ||
| 413 | MCH receptor-1 antagonists for the treatment of obesity Anthony L Handlon, Kamal A Al-Barazanji, Kevin K Barvian, Andrew J Carpenter, Joel P Cooper, Aaron S Goetz, Gary M Green, Yu C Guo, Donald L Hertzog, Clifton E Hyman, Gregory E Peckham, Jason D Speake, Francis X Tavares, Hui-qiang Zhou | ||
| 414 | Novel cyclic lactam α-MSH analogs as potent and selective hMC3R agonists and antagonists, and hMC1R antagonists Alexander V. Mayorov, Minying Cai, So-Yeop Han, Bahar Tan, April R. Van Scoy, Matthew Dedek, Erin S. Palmer, Dev Trivedi, Victor J. Hruby | ||
| 415 | Cyclopropylglycine amide derivatives as potent DPP-IV inhibitors for the treatment of diabetes Abraham Thomas, Ashok Kadam, Mangesh Pawar, Daisy Shah, Kanthikiran Varanasi, Anupindi Raghuram, Shridhar Narayanan, Swaroop V. Vakkalanka | ||
| 416 | 3-[2-((2S)-2-Cyano-pyrrolidin-1-yl)-2-oxo-ethylamino]-3-methyl-butyramide analogs as DPP-IV inhibitors for the treatment of type-II diabetes Hsing-Pang Hsieh, Mohane S. Coumar, Chung-Nien chang, Ssu-Hui Wu, Xin Chen, Chiung-Tong Chen, Weir-Torn Jiaang | ||
| 417 | Synthesis and the structure-activity relationships of cyclohexene-constrained phyenethylamine as Dipeptidyl Peptidase IV inhibitor Xiaofeng Li, Zhonghua Pei, Thomas W. von Geldern, David J. Madar, Kenton Longenecker, Hong Yong, Thomas H. Lubben, Kent D. Stewart, Stephen J. Ballaron, Michael A. Stashko, Amanda K. Mika, David W. A. Beno, Glenn A. Reinhart, Anita J. Kempf-Grote, Hing L. Sham, James M. Trevillyan | ||
| 418 | Potent inhibitors of DPP-IV: 2-cyano-4-fluoro-1-thiovalylpyrrolidine analogs Steven M. Reister, Curt D. Haffner, Darryl L. McDougald, Brian D. Thompson, Christopher Conlee, Jing Fang, Jonathan Bass, James M. Lenhard, Dallas Croom, Melissa B. Secosky-Chang, Thaddeus Tomaszek, Donovan McConn, Kevin Wells-Knecht, Paul R. Johnson | ||
| 419 | Discovery of indazole derivatives as potent leukotriene A4 hydrolase inhibitors Lei Zhao, Bjorn Mamat, Rama Mishra, Guđrún Halldórsdóttir, Heioa Sigporsdottir, Thorkell Andression, David Zembower, Mark Gurney, Jasbir Singh, Vincent Sandanayaka | ||
| 420 | Design, synthesis, and SAR of novel leukotriene A4 hydrolase inhibitors containing chiral piperidine and piperazine scaffolds Vincent Sandanayaka, Bjorn Mamat, Louis Bedell, Nikhil Bhagat, Brian Bock, Michael Krohn, Rama Mishra, Emmanuel Onua, Jun Zhang, Guđrún Halldórsdóttir, Heiđa Sigţórsdóttir, Thorkell Andression, David Zembower, Mark Gurney, Jasbir Singh | ||
| 421 | Azabenzimidazole-aminofurazans as potent and selective Rho-kinase inhibitors Robert A. Stavenger, Dennis Lee, Robert L. Ivy, Weiwei Xu, Simon F. Semus, Larry J. Jolivette, Lois L. Wright, Ross Bentley, Christopher P. Doe, Erding Hu | ||
| 422 | Potent ABCA1 elevating compounds, derivatives of tranexamic acid Dmitry Koltun, Melanie Boze, Bindu Joshi, Richard Lawn, Jia Hao, David Lustig, Kwan Leung, Jeff Zablocki | ||
| 423 | Tetrahydro napthyridine as inhibitors of cholesteryl ester transfer protein Saravanan Parthasarathy, Maria-Carmen Fernandez, Ana I Mateo, Ana Escribano, Eva M Martin de la Nava, Xiaodong Wang, Sandra L Cockerham, Thomas P Beyer, Robert J Schmidt, Guoging Cao, Gregory Stephenson, Nathan B Mantlo | ||
| 424 | Potent, macrocyclic motilin receptor antagonists incorporating new unnatural amino acids Eric Marsault, Kamel Benakli, Sylvie Beaubien, Carl Saint-Louis, Robert Déziel, Graeme Fraser | ||
| 425 | Potent and selective protein tyrosine phosphatase 1b inhibitors Zhao-Kui Wan, Jinbo Lee, Douglas Wilson, Dave Erbe, Weixin Xu, Yan-Ling Zhang, Lori Klaman, Diane Joseph-McCarthy, Xin Xu, Bruce Follows, Junjun Wu, Steven Kirincich, Alessandro F. Moretto, Eva Binnun, Rajeev Hotchandani, Manus Ipek, May Tam, Sarah Will, Ariful Qadri, James Tobin, Steve Tam | ||
| 426 | Probing acid replacements of PTP1B inhibitors Steven J. Kirincich, Bruce Follows, Zhao-Kui Wan, Douglas P. Wilson, Junjun Wu, Weixin Xu, Diane Joseph-McCarthy, May Tam, Dave Erbe, Steve Tam, James Tobin, Yanling Zhang, Jinbo Lee | ||
| 427 | Polycyclic thiophenes as protein tyrosine phosphatase 1B inhibitors Alessandro F. Moretto, Steven J. Kirincich, WX. Xu, Michael J. Smith, Zhao-Kui Wan, Douglas P. Wilson, Bruce Follows, Eva Binnun, Diane Joseph-McCarthy, Kenneth Foreman, Dave Erbe, Yanling Zhang, Steve Tam, Jinbo Lee | ||
| 428 | P2Y1 antagonists: An analysis of the structural elements of ligand recognition based on molecular docking and 3D-QSAR Stefano Costanzi, Michihiro Ohno, Eun Joo Roh, Bhalchandra V. Joshi, Anny-Odile Colson, Dayle Houston, Savitri Maddileti, T. Kendall Harden, Kenneth Jacobson | ||
| 429 | Selective benzimidazolone ß3 adrenergic receptor agonists with reduced rat atrial tachycardia Don R. Finley, William E. Bloomquist, Donald B. Bennett, Marlene L. Cohen, Mark L. Heiman, Aidas Kriauciunas, Daniel J. Sall, Frank C. Tinsley, Cynthia D Jesudason | ||
| 430 | Synthesis and SAR of novel alkoxyphenyl pyrazole urea derivatives Honnappa Jayakumar, Bradley R. Teegarden, Sonja Strah-Pleynet, Hongmei Li, Naomi Kato, Katie Elwell, Susan D. Selaya, Karen Chang, Jarrod Davidson, Jonathan Foster, Stephan Espitia, Hazel Reyes, Xiaohua Chen, William Thomsen | ||
| 431 | Synthesis and SAR of solubilized pyrazole derivatives as 5HT2A inverse-agonists for platelet aggregation Peter Dosa, Bradley Teegarden, Honnappa Jayakumar, Sonja Strah-Pleynet, Yifeng Xiong, Martin Casper, Jin Sun Choi, Marc Decaire, Hongmei Li, Katie Elwell, John Adams, Stephen Espitia, Juan Ramirez, Jeremy Richman, William Thomsen, Diane Yuskin, Hong Zheng | ||
| 432 | Design and synthesis of 2-amino-4-anilino-6-substituted pyrrolo[2,3-d]pyrimidines as antiangiogenic agents Aleem Gangjee, Ojas A. Namjoshi, Michael Ihnat, Linda A. Warnke, Jessica E. Thorpe | ||
| 433 | The efficient synthesis for the segment of Aliskiren Rujian Ma, Feiyu Tang, Shuhui Chen, Ge Li | ||
| 434 | Selective PDE11A inhibitors as glucose-dependent insulin secretagogues: Synthesis and SAR of 1,8-naphthyridinones Yamin Wang, Teresa Bear, William Bullock, Libing Chen, Leatte Guernon, David Gunn, Laszlo Hunyadi, Richard Kramss, Tindy Li, Sidney Liang, Qingjie Liu, Donglei Liu, Steven Magnuson, Gretchen Mannelly, David Miller, Eric Mull, Reina Natero, Dennis O’Keefe, Ning Qi, Jill Wood, Nicole Barucci, Marina Breuhaus, Thomas Claus, Michelle Daly, Lynn Lemoine, Yaxin Li, James Livingston, Laurel Sweet, Adrian Tersteegen, Hong Wang, Jian Zhu, Rainer Heurich | ||
| 435 | Selective PDE11A inhibitors as glucose-dependent insulin secretagogues: Synthesis and SAR of 1,6-naphthyridinones William Bullock, Libing Chen, Nicole Barucci, Marina Breuhaus, Thomas Claus, Michelle Daly, David Gunn, Lynn Lemoine, Yaxin Li, Qingjie Liu, James Livingston, Laurel Sweet, Adrian Tersteegen, Christopher Town, Hong Wang, Jian Zhu, Rainer Heurich, Yamin Wang | ||
| 436 | Design, synthesis and relaxant activity of 2-(substituted phenyl)-1H-benzimidazoles on isolated rat aortic rings Gabriel Navarrete-Vazquez, Samuel Estrada-Soto, Rafael Villalobos-Molina, Ismael Leon-Rivera, Hermenegilda Moreno-Diaz, Mariana Torres-Piedra, Francisco Aguirre-Crespo, Jorge Vergara-Galicia | ||
| 437 | Structure-activity relationships of 2, N6, 5'-substituted adenosine derivatives as human A2B adenosine receptor agonists Hayamitsu Adachi, Krishnan K. Palaniappan, Zhan-Guo Gao, Kenneth A. Jacobson | ||
| 438 | Structure activity relationship of uridine 5′–diphosphoglucose (UDP-glucose) analogs at the human P2Y14 receptor Hyojin Ko, Ingrid Fricks, Andrei A. Ivanov, T. Kendall Harden, Kenneth A. Jacobson | ||
| 439 | Structure-activity relationships of carboxylic acid derivatives of PPADS (pyridoxal-5'-phosphate-azo-disulfonic acid) as P2X receptor antagonists Yong-Chul Kim, Kwan-Young Jung, Ju Yeon Lee, Ga Eun Lee, Hyo Joon Kim | ||
| 440 | Discovery of tetrahydrofluorenones as a new class of estrogen receptor ß-subtype selective ligands Robert R Wilkening, Ronald Ratcliffe, Erin Tynebor, Kenneth Wildonger, Amy Fried, Milton Hammond, Ralph Mosley, Paula Fitzgerald, Nandini Sharma, Brian McKeever, Stephan Nilsson, Matts Carlquist, Anne Thorsell, Louis Locco, Robert Katz, Katalin Frisch, Elizabeth Birzin, Hilary Wilkinson, Sudha Mitra, Sheng-Jian Cai, Edward Hayes, James Schaeffer, Susan Rohrer | ||
| 441 | Tetrahydrofluorenones with conformationally restricted side chains as selective estrogen receptor beta ligands Kenneth J. Wildonger, Ronald Ratcliffe, Ralph Mosley, Milton L. Hammond, Elizabeth T. Birzin, Susan P. Rohrer | ||
| 442 | 1,5-Dihydro-benzo[e][1,4]oxazepin-2(1H)-ones containing A 7-(5'-cyanopyrrol-2-yl) group as nonsteroidal progesterone receptor modulators Puwen Zhang, Jeffrey C. Kern, Eugene A. Terefenko, Andrew Fensome, Ray J Unwalla, Yuan Zhu, Jeff Cohen, Richard C. Winneker, Zhiming Zhang, Jay Wrobel | ||
| 443 | Establishment of a QSAR model for the prediction of the neuroprotective and antioxidant properties of different estrogen analogs Nilka M. Rivera, Laszlo Prokai | ||
| 444 | A useful oral bioavailability/plasma exposure model for 4-(2-phenyl)benzimidazole GnRH antagonists based on a narrow set of physico-chemical molecular properties Jeffrey C. Pelletier, Daniel Green, Murty V. Chengalvala, Irene B. Feingold, Christine Huselton, Jay Wrobel | ||
| 445 | Synthesis and biological evaluation of benzoxazole and benzothiazole antagonists of the GnRH receptor Matthew D. Vera, Murty V. Chengalvala, Joshua E. Cottom, Daniel Green, Diane B. Hauze, Joseph T. Lundquist IV, Charles W. Mann, Jeffrey C. Pelletier, Linda Shanno, Jay Wrobel | ||
| 446 | Synthesis and evaluation of GnRH receptor antagonists containing piperazinylimidazopyridine and piperazinyltriazolopyridine scaffolds Joseph T. Lundquist IV, Matthew D. Vera, Jeffrey C. Pelletier, Jay Wrobel, Joshua E. Cottom, Linda Shanno, Murty V. Chengalvala, Christine Huselton, Irene B. Feingold | ||
| 447 | Structural exploration of a novel class of tricyclic benzodiazepine follicle-stimulating hormone receptor (FSH-R) antagonists: Part I Amedeo A. Failli, Gavin D. Heffernan, Dominick A. Quagliato, Arthur A. Santilli, Patrick M. Andrae, Richard D. Coghlan, Eugene J. Trybulski, Gi-Chung Chen, Jamin Chi, Tracy L. Owtscharuk, Maria Claudia Perez, Emily S. Shen | ||
| 448 | Structural exploration of a novel class of tricyclic benzodiazepine follicle-stimulating hormone receptor (FSH-R) antagonists: Part II Gavin D. Heffernan, Amedeo A. Failli, Dominick A. Quagliato, Arthur A. Santilli, Richard D. Coghlan, Eugene J. Trybulski, Patrick M. Andrae, Gi-Chung Chen, Jamin Chi, Tracy L. Owtscharuk, Maria Claudia Perez, Emily S. Shen | ||
| 449 | EP4 receptor agonists as ocular hypotensive agents John Colucci | ||
| 450 | Biaryl thiazolidin-2,4-diones: A new class of voltage-gated sodium channel blockers for treatment of neuropathic pain P. K. Chakravarty, C. H. Kuo, S. Tyagarajan, M. Ayer, W. H. Parsons, M. H. Fisher, M. J. Wyvratt, K. A. Lyons, Birgit T. Priest, Richard M. Brochu, I. E. Dick, G. J. Kaczorowski, E. McGowan, Nina Jochnowitz, J. W. Tarpley, S. West, B. S. Reiseter, Catherine Abbadie, W. J. Martin | ||
| 451 | Synthesis and structure-activity relationships of a series of 5-methyl 5-phenylimidazolidine-2,4-dione derivatives as a Kv1.1/β1 potassium channel disinactivator Callain Y. Kim, Wayne E. Childers Jr., Boyd L. Harrison, Magid Abou-Gharbia, Mark Bowlby, Flora Jow, Tony Lee, Steve Lin, Mike Monaghan, Kenneth Rhodes, Qiang Wang, Howard Zhang | ||
| 452 | Paper Withdrawn | ||
| 453 | Synthesis and SAR study of b-phenylalanine sulfonamide derivatives as bradykinin B1 receptor antagonists for the treatment of pain and inflammation Nianhe Han, Kaustav Biswas, Lynn Cai, Jennifer Chau, Jian Chen, Derin D'Amico, Christopher H. Fotsch, Aiwen Li, Qingyian Liu, Bobby Riahi, Phi Tang, Chester Yuan, Jiawang Zhu, Gloria Biddlecome, Bob Groneburg, Hsieh Faye, Eileen Johnson, Janan Jona, Smriti Joseph, Gondi Kumar, Dennis Lei, Dianna Lester-Zeiner, Carlo van Staden, Gorden Ng, Ben Askew | ||
| 454 | Preparation of 2-substituted cyclopropylglycine amide human bradykinin B1 receptor antagonists Robert M. DiPardo, Ronald K. Chang, Kathy L. Murphy, Richard W. Ransom, Yvonne Leonard, Cuyue Tang, Thomayant Prueksaritanont, Douglas J. Pettibone, Mark G. Bock, Scott D. Kuduk | ||
| 455 | Potent and orally bioavailable Bradykinin B1 antagonists based on a 5-pyrimidinyl cyclopropanecarboxamide core Jenny Wai, Neville J. Anthony, Christina Ng Di Marco, Dong-Mei Feng, Robert P. Gomez, Kathy Schirripa, Michael R. Wood, Kathy L. Murphy, Richard W. Ransom, Cuyue Tang, Thomayant Prueksaritanont, Douglas J. Pettibone, Roger M. Freidinger, Mark G. Bock, Scott D. Kuduk | ||
| 456 | Three dimensional chemical-feature-based pharmacophore development for kappa opioid receptor agonist Nidhi Singh, Gwénaël Chevé, Christopher R. McCurdy | ||
| 457 | Paper Withdrawn | ||
| 458 | Paper Withdrawn | ||
| 459 | Further modification of aminothiazolomorphinans Ao Zhang, Zhaohua Yan, John L. Neumeyer, James E. Hilbert, Emily K DeVita, Jean M. Bidlack | ||
| 460 | Synthesis and preliminary in vitro investigation of carbamate analogs of morphinan pharmacophores at mu, kappa and delta opioid receptors Xuemei Peng, Brian I. Knapp, Jean M. Bidlack, John L. Neumeyer | ||
| 461 | Synthesis and preliminary in vitro investigation of bivalent ligands containing hetero-pharmacophores at mu, delta and kappa opioid receptors Xuemei Peng, Brian I. Knapp, Jean M. Bidlack, John L. Neumeyer | ||
| 462 | Design, synthesis and evaluation of original 2(3H)-benzoxazolones and 2(3H)-benzothiazolones as highly potent sigma receptor antagonists Sanju Narayanan, Christophe Mesangeau, Jamal Shaikh, Jie Yu, Jeffery A. Diers, Rae R. Matsumoto, Jacques H. Poupaert, Christopher R. McCurdy | ||
| 463 | Discovery of an orally available and brain penetrable 6-(piperazine-1-yl)- benzimidazole ORL-1 antagonist Osamu Okamoto, Kensuke Kobayashi, Hiroshi Kawamoto, Satoru Ito, Atsushi Satoh, Tetsuya Kato, Sayaka Mizutani, Masaya Hashimoto, Atsushi Shimizu, Hiroki Sakoh, Yasushi Nagatomi, Yoshikazu Iwasawa, Hiroyuki Takahashi, Yasuyuki Ishii, Satoshi Ozaki, Hisashi Ohta | ||
| 464 | Optimization of a benzimidazole series as opioid receptor-like 1 (ORL1) antagonists Kensuke Kobayashi, Minaho Uchiyama, Hirobumi Takahashi, Hiroshi Kawamoto, Satoru Ito, Takashi Yoshizumi, Hiroshi Nakashima, Tetsuya Kato, Atsushi Shimizu, Hiroshi Miyazoe, Masanori Asai, Akio Ohno, Mioko Hirayama, Satoshi Ozaki, Takeshi Tani, Takeshi Tanaka, Takanobu Mochidome, Kiyoshi Tadano, Fukuroda Takahiro, Osamu Okamoto, Hisashi Ohta | ||
| 465 | Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands: Part 1 John Caldwell, Julius Matasi, Hongtao Zhang, April Smith Torhan, Ahmad Fawzi, Deen Tulshian | ||
| 466 | Synthesis and structure-activity relationships of N-substituted spiropiperidines as nociceptin receptor ligands: Part 2 John Caldwell, Julius Matasi, Hongtao Zhang, April Smith Torhan, Ahmad Fawzi, Deen Tulshian | ||
| 467 | Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 1 Ginny D Ho, Ana Bercovici, Ahmad Fawzi, April Smith Torhan, Deen Tulshian, Hongtao Zhang | ||
| 468 | Synthesis and structure-activity relationships of 4-hydroxy-4-phenylpiperidines as nociceptin receptor ligands: Part 2 Ginny D Ho, Ana Bercovici, Ahmad Fawzi, April Smith Torhan, Deen Tulshian, Hongtao Zhang | ||
| 469 | Synthesis and structure-activity relationships (SAR) of N-substituted amide spiropiperidines as nociceptin receptor ligands: Part 3 Julius Matasi, John Caldwell, Hongtao Zhang, Ahmad Fawzi, Deen Tulshian, April S. Torhan | ||
| 470 | Discovery of a cannabinoid-1 receptor PET tracer suitable for clinical use Ping Liu, Linus S. Lin, Terence G. Hamill, James P. Jewell, Thomas J. Lanza, Stephen M. Krause, Christine Ryan, Waisi Eng, Sandra Sanabria, Raymond E. Gibson, Xinchun Tong, Junying Wang, Tung M. Fong, Julie Lao, Sanjeev Kumar, Wenji Yin, Mark T. Goulet, Richard Hargreaves, H, Donald Burns, William K. Hagmann | ||
| 471 | Discovery of a novel cannabinoid-1 receptor inverse agonist for the treatment of obesity William K. Hagmann, Linus S. Lin, Thomas J. Lanza, James P. Jewell, Ping Liu, Shrenik K. Shah, Quang Truong, Hongbo Qi, Ravindra N. Guthikonda, Linda L. Chang, Jonathan Wilson, Helen Armstrong, Ihor E. Kopka, Bing Li, Grace Quaker, Amy Galka, Xinchun Tong, Junying Wang, Sherry Xu, Tung M. Fong, Chun-Pyn Shen, Julie Lao, Jing Chen, Lauren P. Shearman, D. Sloan Stribling, Kimberly Rosko, Alison Strack, Donald J. Marsh, Yue Feng, Sanjeev Kumar, Koppara Samuel, Wenji Yin, Lex H. T. Van der Ploeg, Mark T. Goulet | ||
| 472 | Synthesis and biological evaluation of novel thiazolo[3,2-a]benzimidazole derivatives as metabotropic glutamate receptor 1 antagonists Jiro Fujiyasu, Hirotsune Itahana, Masamichi Okada, Takashi Toya, Toshihiro Watanabe, Minoru Okada, Mitsuaki Ohta | ||
| 473 | Microwave-assisted synthesis of potent mGluR5 antagonists Bin Shao | ||
| 474 | Prodrugs of 3-(3,4-dicholorobenzyloxy)-2-amino-6-fluorobicyclo[3.1.0]hexane- 2,6-dicarboxylic acid (MGS0039): Potent and orally active group II mGluR antagonist with antidepressant-like potential Akito Yasuhara, Masato Nakamura, Kazunari Sakagami, Yasunori Kawakita, Toshiharu Shimazaki, Shigeyuki Chaki, Hiroshi Ohta, Atsuro Nakazato | ||
| 475 | Design and synthesis of 3,5-bis-benzamide substituted DNK 333 analogs as dual NK-1/NK-2 receptor probes Vijaya L. Korlipara, Venkat Manoj Swarna, Bradley J. Undem | ||
| 476 | Series of potent, orally active alpha,alpha-disubstituted piperidine NK1 antagonists Dong Xiao, Cheng Wang, Gregory Reichard, Hon-Chung Tsui, Sunil Paliwal, Anandan Palani, Neng-Yang Shih, Ruth A. Duffy, Gerard Randolph, Jean Lachowicz, Geoffrey Varty, Cynthia Morgan, Fei Liu, Amin Nomeir | ||
| 477 | Improving metabolism of novel cyclic urea NK1 antagonists with amine capping groups Dong Xiao, Carmine Stengone, Gregory Reichard, Neng-Yang Shih, Ruth A. Duffy, Gerard Randolph, Jean Lachowicz, Geoffrey Varty, Cynthia Morgan, Fei Liu, Amin Nomeir | ||
| 478 | Novel piperidine scaffold as an orally active NK1 antagonist Jonathan R. Young, Ronsar Eid, Robert J. DeVita, Gary G. Chicchi, Kwei-Lan C Tsao, Marc Kurtz, James V. Pivnichny, Sharon Tong, Song Zheng, Alan Wheeldon, Emma Carlson, Jerry Di Salvo, Ruth Kilburn, Alana Upthagrove, Sanjeev Kumar, Sander G. Mills | ||
| 479 | Synthesis and biological characterization of the NK2 antagonist SLV332 Daniel P. Jasserand, Holger Sann, Reinhard Brueckner, Dania Reiche, Michael Firnges, Emil Finner, Jochen Antel, Ulf Preuschoff | ||
| 480 | Novel lipophilic gamma-hydroxybutyrate (GHB) analogs with high affinity to GHB sites in rat brain Signe Hřg, Petrine Wellendorph, Birgitte Nielsen, Bente Frřlund, Rasmus P. Clausen | ||
| 481 | Determining the amino acids involved in selective allosteric modulation of the α1β3γ2 and α2β3γ2 GABAAR subtypes Niki M. Zacharias, Ashutosh A. Kulkarni, Elisha D. Mackey, John B. Nicholas, Mark W. Nowak, Sue Dee Sahba, Nima W. Shiva | ||
| 482 | Novel hydroxypyrazol-based ligands for characterizing the GABAA binding site Henriette M. Hansen | ||
| 483 | Synthesis of isotopically labelled GABA Robert L. White, Matthew C. Cook | ||
| 484 | Design and synthesis of novel inhibitors of fatty acid amide hydrolase Joie Garfunkle, F. Anthony Romero, Dale L. Boger | ||
| 485 | In vivo imaging of the CRF1 receptors with positron emission tomography J. S. Dileep Kumar, Gregory M. Sullivan, Ramin V. Parsey, Victoria Arango, Yung-yu Huang, Vattoly J Majo, Jaya Prabhakaran, Ronald L. Van Heertum, J. John Mann | ||
| 486 | Synthesis of deuterium-labeled antipsychotic drugs Heiko Junga, Xiangyu Jiang, Christopher James Randlett | ||
| 487 | Binding selectivity of substituted diarylmethanes to serotonin transporters (SERT) Balagopal Lakshmi, Seok-Rye Choi, Rajesh Chandra, Zhi-Ping Zhuang, Hank F. Kung | ||
| 488 | Further structural exploration of tri-substituted asymmetric pyran derivatives, (2S, 4R, 5R)-2-benzhydryl-5-benzylamino-tetrahydropyran-4-ol and their corresponding disubstituted (3S,6S) pyran derivatives: Development of potent molecules for serotonin and norepinephrine transporters Shijun Zhang, Fernando Fernandez, Stuart Hazeldine, Juan Zhen, Maarten Reith, Aloke Dutta | ||
| 489 | Synthesis and in vivo evaluation of 5-HT1A receptor agonist radioligand [O-methyl-11C]2-(4-(2-methoxyphenyl)piperazin-1-yl)butyl) -4-methyl-1,2,4-triazine-3,5(2H,4H)dione in nonhuman primates J. S. Dileep Kumar, Jaya Prabhakaran, Vattoly J Majo, Matthew Milak, Norman R. Simpson, Agata Bukowska, Ronald L. Van Heertum, J. John Mann, Ramin V. Parsey | ||
| 490 | Synthesis and biological evaluation of a new series of nicotinic acetylcholine receptor (nAChR) ligands for positron emission tomography (PET) Yongjun Gao, Hayden T Ravert, Daniel Holt, John Hilton, Chris Endres, Mohab Alexander, Anil Kumar, Arman Rahmim, Hiroto Kuwabara, Dean F. Wong, Robert F. Dannals, Andrew G. Horti | ||
| 491 | Acetylcholine binding proteins (AChBPs) as soluble surrogates of the extracellular ligand binding domain of nicotinic acetylcholine receptors (nAChRs) Todd T Talley, Palmer Taylor | ||
| 492 | N-Heteroaryl bridged bicyclic diamines are potent agonists at neuronal nicotinic receptors William H. Bunnelle, Daniela Barlocco, Michael D. Meyer, Keith B. Ryther, Michael R. Schrimpf, Michael J. Dart, Jennifer M. Frost, Arianna Gelain, Jerome F. Daanen, Xenia Searle, David J. Anderson, Pamela Puttfarcken, Jun Chen, Peter Curzon, Michael J. Buckley, Carol S. Surowy | ||
| 493 | Aryl amide motif with potent D2/5HT2A antagonist activity James M. Graham, Barr Bridgett, Stephen Cho, Coughenour Linda, Terry Crawford, Tracy F. Gregory, Sham S. Nikam, David Rock, Jamie Singer, Michael A. Walters | ||
| 494 | Novel sulfonamides having high dual dopamine D2 and D3 receptor affinity show in vivo antipsychotic efficacy with beneficial cognitive and EPS profile G. M. Keserû, É. Ágai-Csongor, J. Galambos, K. Nógrádi, I. Vágó, A. Bielik, B. Kiss, I. Laszlovszky, K. Sághy, J. Laszy, I. Gyertyán, L. Gémesi, M. Zájer-Balázs, Gy. Domány | ||
| 495 | Positional isomers and bio-isosteric analogs of 7-{[4-(4-Phenyl-piperazin-1-yl)-butyl]-propyl-amino}-5,6,7,8-tetrahydro-naphthalen-2-ol for their preferential interaction at the dopamine D3 receptors Swati Biswas, Juan Zhen, Maarten Reith, Aloke Dutta | ||
| 496 | Identification of novel, orally-active inhibitors of the TRPV1 (VR1) receptor Zhi-Liang Wei, Yunfeng Fang, Carl Kaub, Satyanarayana Janagani, Kiran Sahasrabudhe, Guoxhian Wu, John Kincaid, Matthew Duncton, David Lonergan, Nina Orike, Krithika Ramomoorthy, Michelle Dourado, Alejandra Acevedo, Fabien Vincent, David Hackos, Qingling Zhang, Luna Liu, Jennifer Shumilla, Karly Maruyama, Nadia Haque, Tilmann Brotz, Daniel Emerling, Kathleen Martin, Junji Takada, Kazunari Nakao, Katsuhiro Baba, Tetsuhiko Nakagawa, Kenzo Yamamura, Michael Kelly | ||
| 497 | Design and synthesis of TRPV1 antagonists: Inclusion of a D region binding moiety and a stereocenter David B. Rusterholz, Karen K. Klyczek, Lucas J. Stolp, Ryan E. Williams, Nicole J. Wellnitz | ||
| 498 | Tetrahydroquinoline containing ureas as novel transient receptor potential vanilloid 1 (TRPV1) antagonists for the treatment of pain Robert G. Schmidt, Arthur Gomtsyan, Steven P. Latshaw, Tammie K Jinkerson, Jerome F. Daanen, Heath A. McDonald, Bruce Bianchi, Pamela Puttfarcken, Robert Moreland, Minglei Cui, Prisca Honore, Karen St. George, John F. Darbyshire, Kennan C. Marsh, Teresa Turner, Connie R. Faltynek, Chih-Hung Lee | ||
| 499 | 4-(Pyridin-2-yl)-piperazine-N-hydroxy-1-carboxamidine analogs as TRPV1 antagonists Xiaoming Zhou, Qun Sun, Donald J. Kyle | ||
| 500 | Benzoimidazole-2-carboxamides as novel NR2B selective NMDA receptor antagonists György Domány, István Borza, Sándor Kolok, Anikó Gere, Kornél Galgóczy, Ildikó Magdó, József Fetter, Ferenc Bertha, Béla Ágai, Csilla Horváth, Sándor Farkas, György M. Keserű | ||
| 501 | Benzimidazole-substituted (3-phenoxypropyl)amines as histamine H3 receptor ligands Robert Aslanian, Xiaohong Zhu, Wing Tom, Wei Zhou, Daniel Solomon, Neng-Yang Shih, John J. Piwinski, Robert West, Shirly M. Williams | ||
| 502 | Synthesis of optically active subtype selective BZR ligands Shengming Huang, Clayton Terry, Minghuan Dai, Rahul Edwankar, Chitra Sawant, James M. Cook | ||
| 503 | 3-Normeridamycin: A pNon-immunosuppressive immunophilin ligand is neuroprotective in dopaminergic neurons Mia Y. Summers, Margaret Leighton, Danni Liu, Kevin Pong, Edmund I. Graziani | ||
| 504 | Synthesis of fluoro-PEGylated thiophene derivatives for β-amyloid plaque imaging Rajesh Chandra, Karin Stephenson, Mei-Ping Kung, Catherine Hou, Hank F. Kung | ||
| 505 | Synthesis of TrkA agonists: Development of therapeutics for treatment of Alzheimer's disease Rui Zhang, Christine L. Willis, Richard B Sessions, Debbie K Shoemark, Judy J Watson, Mark S Fahey, Gordon K Wilcock, Shelley J Allen, David Dawbarn | ||
| 506 | Binding sites identification of Abeta-amyloid plaques in Alzheimer's disease based on small molecule ligands Lisheng Cai, Robert B. Innis, Victor W. Pike | ||
| 507 | Discovery of cell permeable hydroxyethylamine BACE inhibitors Roy K. Hom, Michel C. Maillard, Shumeye Mamo, Michael S. Dappen, Louis Brogley, Andrea F. Gailunas, Varghese John, Eugene D. Thorsett, Timothy E. Benson, Danielle D. Woods, D. Bryan Prince, Donna J. Paddock, Thomas L. Emmons, Alfredo G. Tomasselli, Joseph B. Moon | ||
| 508 | Design and development of cyclic amine BACE1 inhibitors: An overview Jared Cumming, Lingyan Wang, Suresh Babu, Carolyn Carroll, Xia Chen, Paul Gaspari, William Greenlee, Tao Guo, Doug Hobbs, Ying Huang, Ulrich Iserloh, Matthew Kennedy, Reshma Kuvelkar, Thuy Le, Guoqing Li, Jeffrey Lowrie, Lynne Ozgur, Jianping Pan, Kurt Saionz, Corey Strickland, Andrew Stamford, Dawit Tadesse, Johannes Voigt, Yusheng Wu | ||
| 509 | Discovery and development of novel BACE-1 inhibitors: Substituted piperidine analogs Yusheng Wu, Andrew Stamford, Jared Cumming, Ulrich Iserloh, William Greenlee, Matthew Kennedy, Xia Chen, Reshma Kuvelkar, Nansie McHugh, Johannes Voigt, Corey Strickland, Leonard Favreau, Cheng Li, TongTong Liu, Tze-Ming Chan, Rebecca Osterman | ||
| 510 | Discovery of highly potent piperazine BACE-1 inhibitors Ying Huang, Xia Chen, William Greenlee, Matthew Kennedy, Reshma Kuvelkar, Guoqing Li, Eric M. Parker, Andrew Stamford, Corey Strickland, Johannes Voigt, Lili Zhang | ||
| 511 | Discovery of potent pyrrolidine BACE-1 inhibitors Ulrich Iserloh, Jianping Pan, Alex Buevich, Xia Chen, Jared Cumming, Len Favreau, William Greenlee, Ying Huang, Matthew Kennedy, Reshma Kuvelkar, Nansie McHugh, Guoqing Li, Eric M. Parker, Corey Strickland, Andrew Stamford, Greg Tucker, Johannes Voigt, Lingyan Wang, Yusheng Wu, Ji Zhang, Lili Zhang | ||
| 512 | Application of diverse computational methods to the optimization of amino-ethanol BACE-1 inhibitors Johannes Voigt, Jared Cumming, Suresh Babu, Xia Chen, William Greenlee, Tao Guo, Ying Huang, Ulrich Iserloh, Thuy Le, Guoqing Li, Matthew Kennedy, Reshma Kuvelkar, Jianping Pan, Corey Strickland, Dawit Tadesse, Lingyan Wang, Yusheng Wu, Andrew Stamford | ||
| 513 | Discovery of potent macrocyclic BACE-1 inhibitors Guoqing Li, Ying Huang, Andrew W. Stamford, William J. Greenlee, Matthew Kennedy, Xia Chen, Reshma Kuvelkar, Corey Strickland, Johannes Voigt | ||
| 514 | Geometrically constrained p3 amide replacement of beta-secretase inhibitor Elizabeth F. Stanton, Shawn J. Stachel, Craig A. Coburn, Thomas G. Steele, Ming Chih Crouthamel, Beth L. Pietrak, Ming Tain Lai, Adam J. Simon, Lixia Jin, M. Katherine Holloway, Georgia McGaughey, Samuel L. Graham, Joseph P. Vacca | ||
| 515 | Solid phase synthesis of competitive BACE inhibitors Didier JC Berthelot Berthelot, Francois Bischoff, Serge Pieters, Mirielle Braeken, Hans de Winter, Marc Mercken, Ludo Kennis, Lieven Meerpoel | ||
| 516 | Natural products based beta-secretase inhibitors from Aloe spp. plants and H. occulta Wei-Shuo Fang, Qing-Yun Yang, Xiao-Yan Tian, Bo Gao, Liang Lv, Chun-Suo Yao, Yue-hua Wang, Guan-hua Du | ||
| 517 | Systematic comparison of cell permeability between cyclic and linear peptides using reporter gene-based assay Yong-Uk Kwon, Thomas Kodadek | ||
| 518 | A peptidomimetic siRNA transfection reagent for highly effective gene silencing in diverse cell types Yeliz Utku, Ouathek Ouerfelli, Fabio Piano, Ronald N. Zuckermann, Michele Pagano, Kent Kirshenbaum | ||
| 519 | Synthetic elastic polymer/collagen fibril biocomposite for artificial tissue design Kerriann Robyn Greenhalgh, Edward Turos, Thomas J. Koob | ||
| 520 | Use of the 4-hydroxy-1,2,5-oxadiazole-3-yl moiety as novel bioisoster of the distal carboxyl group of the (S)-glutamic acid Marco L. Lolli, Cecilia Giordano, Birgitte Nielsen, Tommy N. Johansen, Roberta Fruttero, Alberto Gasco | ||
| 521 | Bisphosphonate binding to farnesyl diphosphate synthase by NMR, X-ray crystallography, calorimetry and quantum chemistry Fenglin Yin, Sujoy Mukherjee, Junhong Mao, Yong Zhang, Rong Cao, John M. Sanders, Yongcheng Song, Yonghui Zhang, Gary A. Meints, Yi Gui Gao, Dushyant Mukkamala, Michael P. Hudock, Amanda Goddard, Eric Oldfield | ||
| 522 | Polymeric hollow spheres as controlled drug-delivery vehicles Zhi-hang Tang, Bao-An Yang | ||
| 523 | Gold-immobilized cytochrome P450 2C9 metabolism: On chip technology Peter M. Gannett, Jarod L. Kabulski, Felio A. Perez, Zhongyuan Liu, David Lederman, Charles W. Locuson, Robyn R. Ayscue, Nissa M. Thomsen, Timothy S. Tracy | ||
| 524 | Synthesis and application of a new molecular probe for the detection of hydroxyl radicals Amarjit Singh, S. James Adelstein, Amin I. Kassis | ||
| 525 | Synthesis and guanase inhibition studies of heterocycles and nucleosides containing the imidazo[4,5-d]pyridazine ring system Ravi K. Ujjinamatada, Ramachandra S. Hosmane | ||
| 526 | Novel synthesis method of nor-pyrenophorin and other macrodiolides via dilatonization for construction a macrodiolide skeleton Liu-Lan Shen, Moo-Sung Ko, Jin-Hyun Jeong | ||
| 527 | Potent antagonists of the Grb2-SH2 domain: Not relying on phosphotyrosine mimics Sheng Jiang, Peng Li, Megan L. Peach, Robert J. Fisher, Marc C Nicklaus, Peter P. Roller | ||
| 528 | Rapid synthesis of anhydrous tetrabutylammonium fluoride from potassium fluoride Haoran Sun, Stephen G. DiMagno | ||
| 529 | Fluorescent probes to study serine/threonine phosphatases Fengtian Xue, Christopher T. Seto | ||
| 530 | Utilizing bound reagents and scavengers with microwave heating, an enabling strategy in medicinal chemistry Shahnaz Ghassemi | ||
| 531 | Preparation of novel Pyridine-2-boronic esters, Pyrimidine-4-boronic esters, Pyrazine-2-boronic esters, and Pyridazine-3-boronic esters through palladium-catalyzed cross-coupling reactions George Y. Li, Xiaomei Qi | ||
| 532 | Design and synthesis of epoxide peptidomimetics as inhibitors of g-glutamyl hydrolase Debatosh Majumdar, Matthew D. Alexander, James K. Coward | ||
| 533 | Visible light-triggered protein inactivation Jiyong Lee, Peng Yu, Thomas J. Kodadek | ||
| 534 | Flow cytometry correlation of antigen display and cobalamin uptake in clinically-derived blood samples Yao Shi, Leah Hartung, David Bahler, Charles B. Grissom | ||
| 535 | Studies toward synthetically determining a pharmacophore of mitragynine, and indole alkaloid from Mitragyna speciosa: Removal of C-ring Jessica E. Adkins, Marcelo J. Nieto, Christopher R. McCurdy | ||
| 536 | Small molecule mass tags for methods of drug discovery Lori I. Robins, Mark J. Kurth | ||
| 537 | Medicinal chemistry refinement of a lead compound improves ex vivo metabolic stability with retention of in vivo functions and bioavailability Laura K. Wing, Hantamalala Ralay Ranaivo, Heather A. Behanna, Wenhui Hu, Sakti M. Roy, Danielle English, D. Martin Watterson | ||
| 538 | Synthesis and evaluation of ring EB analogs of methyllycaconitine Bergmeier Stephen C, Junfeng Huang, Dennis B. McKay, Susan McKay | ||
| 539 | A quantum dot DNA aptamer linked system for detecting proteins Eric Holwitt, Veronica Franz | ||
| 540 | Polyketide engineering to supply advanced, complex scaffolds for the construction of high diversity, natural product-like combinatorial libraries Jasmina Nikodinovic, Bradley A. Bessette Jr., James E Cox, Stephen C. Bergmeier, Mark C. McMills, Nigel D Priestley, Dennis L Wright | ||
| 541 | Methyl nonactate as a starting scaffold for the parallel synthesis of compound libraries Stephen C. Bergmeier, Abhijit Nayek, Gregg Wells, Joshua Phillips, P. Whitney Swain III, Bradley A. Bessette Jr., Nigel D. Priestley, Mark C. McMills, Dennis L. Wright | ||
| 542 | Remote functionalization of the nonactin scaffold via intramolecular insertion Mark C. McMills, Jason H. Stengel, Stephen C. Bergmeier, Nigel D. Priestley, Dennis L Wright | ||
| 543 | Fluorescence polarization (FP) assay for identification of vitamin D receptor (VDR) ligands Steven R. Duff, James G. Farnham, Bryan D. Marks, Naveeda Qadir, Hildegard C. Eliason, Mohammed Saleh Shekhani, Christina Fernandez-Perez, Kurt W. Vogel, William J. Frazee | ||
| 544 | A new agelasine derivative from the Caribbean sponge Agelas clathrodes Ivett C. Pina, Phillip Crews, Karen Tenney | ||
| 545 | Exceptionally facile asymmetric allylboration of aldehydes in water with IPC2Ballyl reagent at high temperatures Kanth V. B. Josyula, Dinara S. Gunasekera, Sreedhar R. Tummalapalli, Venkata J. Reddy, Pavan K. Mallela, Justin R. Kruger, Venkatram R. Mereddy | ||
| 546 | Novel synthesis of heterocyclic fluorous b-amino acids using a multifunctional scaffold Xiaobing Wang Sr., Kit S. Lam | ||
| 547 | A highly convergent synthesis of the vision pigment A2-E Murali Mohan Reddy Peram Surakattula, Paul Wentworth Jr. | ||
| 548 | ALOGPS (http://www.vcclab.org) is a free on-line program to predict lipophilicity and aqueous solubility of chemical compounds Igor V. Tetko, Vsevolod Y. Tanchuk | ||
| 549 | Virtual computational chemistry laboratory (VCCLAB) http://www.vcclab.org Igor V. Tetko, Johann Gasteiger, Roberto Todeschini, Andrea Mauri, David J. Livingstone, Peter Ertl, Vladimir A. Palyulin, Eugene V. Radchenko, Nikolay S. Zefirov, Alexander S. Makarenko, Vsevolod Y. Tanchuk, Volodymyr V. Prokopenko | ||
| 550 | Effects of omega-3 fatty acids on arachidonate and linoleate product distribution in free radical mediated oxidations Todd A. Davis, Ned A. Porter | ||
| 551 | Photophysical and in vitro/in vivo photosensitizing evaluation of 7- and 8-keto bacteriopurpurin-N-alkyl/arylimides derived from Chlorophyll-a Funda Yukruk, Yihui Chen, Gang Zheng, Andrei N. Kozyrev, Janet Morgan, Ravindra K. Pandey | ||
| 552 | Synthesis and study of Resolvin D1 Nicos A. Petasis, Jasim Uddin, Charles N. Serhan | ||
| 553 | Selective (SNAr) arylthiation on aryl substrates bearing multiple substitution sites Frederick A. Luzzio, Marek T. Wlodarczyk | ||
| 554 | Effective synthesis for the segment of BILN-2061 Rujian Ma, Wei Miao, Zhiliiu Zhang, Shuhui Chen, Ge Li | ||
| 555 | Synthetic study toward total synthesis of costunolide Kun Hu, Han-Seo Mun, Keun-Chul Ryu, Jin-Hyun Jeong | ||
| 556 | Asymmetric synthesis of cladiellia-6,11-dien-3-ol by IAEA-IMDA strategy: First synthesis of (E)-cladiellin diterpene Hyoungsu Kim, Hyunjoo Lee, Jayoung Kim, Deukjoon Kim | ||
| 557 | Solid-phase synthesis of prenylcysteine analogs James L Donelson, Heather B. Hodges, Christine A. Hrycyna, Richard A. Gibbs | ||
| 558 | A success story of fragment-based lead generation at Astrazeneca Loredana Spadola, Morten Hohwy, Karl Edman | ||
| 559 | Reversed phase C-18 chromatography: From analytical scale to preparative scale Veronica D. Thomason | ||
| 560 | Molecular recognition characteristics of riboswitch Jinsoo Lim, Ronald R. Breaker | ||
| 561 | Cellular delivery of phosphopeptides by positively-charged tripodal peptides Guofeng Ye, Nguyen H. Nam, Anil Kumar, Keykavous Parang | ||
Symposium Grid -- Division of Medicinal Chemistry -- Session Listing
Symposium Grid -- Drug Discovery -- Session Listing
The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006