MEDIWednesday, 13 September 2006
1:30 PM-4:55 PM Moscone Center -- Room 102, Oral
Antagonists of TRP Channels and Vanilloid Receptors
Organizers:A. Brian Jones
Andrew W. Stamford
1:30 PM Introductory Remarks
1:35 PM314From “screen to clinic”: Discovery of TRPV1 antagonist SB-705498 for treatment of pain
Harshad K Rami
2:15 PM315From arylureas to biarylamides to aminoquinazolines: Discovery of a novel, potent TRPV1 (VR1) antagonist
Xiaozhang Zheng, Charles A. Blum, Kevin J. Hodgetts, Harry Brielmann, Alan J. Hutchison, Bertrand L. Chenard, Frank Burkamp, A. Brian Jones, Peter Blurton, Robert Clarkson, Jayaraman Chandrasekhar, Rajagopal Bakthavatchalam, Stéphane De Lombaert, Marci Crandall, David Matson, Daniel Cortright
2:55 PM316Ureas substituted with partially reduced heteroaromatics as novel transient receptor potential vanilloid 1 (TRPV1) antagonists for the treatment of pain
Arthur Gomtsyan, Erol K. Bayburt, Robert G. Schmidt, Jerome F. Daanen, John R. Koenig, Steven P. Latshaw, Tammie K Jinkerson, Brian S. Brown, Heath A. Mcdonald, Bruce Bianchi, Pamela Puttfarcken, Robert Moreland, Minglei Cui, Prisca Honore, Karen St. George, John F. Darbyshire, Kennan C. Marsh, Connie R. Faltynek, Chih-Hung Lee
3:35 PM317Discovery of potent, selective and orally active TRPV1 antagonists for the relief of pain
Kazunari Nakao, Satoshi Nagayama, Yuji Shishido, Misato Hirano, Masaki Sudo, Junji Takada, Yoshihito Kanai
4:15 PM3182-(Piperazin-1-yl)-1H-benzimidazoles as potent, orally available antagonists of the TRPV1 channel
Vijay K Gore, Chenera Balan, Anthony W Bannon, Yunxin Bo, Celia Dominguez, Christopher Fotsch, Vassil I Ognyanov, Lana Klionsky, Vu V Ma, Yi-Xin Qian, Rami Tamir, Xianghong Wang, Ning Xi, Shimin Xu, Dawn Zhu, Narender R Gavva, James J. S. Treanor, Mark H Norman

Symposium Grid -- Division of Medicinal Chemistry -- Session Listing

Symposium Grid -- Drug Discovery -- Session Listing

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006