| MEDI | Tuesday, 12 September 2006 | ||
1:30 PM-4:50 PM Moscone Center -- Room 103, Oral | |||
General Oral Session | |||
| Sponsored by Biotage | |||
| Organizer: | David P. Rotella | ||
| 1:30 PM | 292 | Aryl indanyl ketones: Novel and efficient inhibitors of the human peptidyl prolyl cis/trans isomerase Pin1 Manfred Braun, Boris Feaux de Lacroix, Anahita Hessamian-Alinejad, Gunter Fischer, Sebastian Daum, Frank Erdmann | |
| 1:50 PM | 293 | SAR of the venlafaxine-like scaffold: Discovery of selective norepinephrine reuptake inhibitors Paige E. Mahaney, Eugene J. Trybulski, Lori K. Gavrin, An T. Vu, Stephen Cohn, Douglas J. Jenkins, Joseph P. Sabatucci, Fei Ye, Michael B. Webb, Kimberly Sipe, Jenifer Leiter, Grace Johnston, Kevin Burroughs, Scott Cosmi, Liza Leventhal, Yingru Zhang, Cheryl Mugford, Sharon Rosenzweig-Lipson, Brian Platt, Darlene C. Deecher | |
| 2:10 PM | 294 | Cyclic guanidine glucagon receptor antagonists for the treatment of type 2 diabetes Ronald M. Kim, Jiang Chang, Ashley R. Lins, Christopher J. Sinz, Maria Beconi, Edward J. Brady, Maria Candelore, Victor Ding, Guoqiang Jiang, Zhen Lin, Sajjad Qureshi, Gino Salituro, Richard Saperstein, Jackie Shang, Laurie Tota, Michael Wright, Xiaodong Yang, James Tata, Bei B. Zhang, Emma R Parmee | |
| 2:30 PM | 295 | 2-Aminothiazole: A novel template for the discovery of Dasatinib (BMS-354825), a pan Src/Abl kinase inhibitor Jagabandhu Das, Ping Chen, Louis J. Lombardo, Francis Y. Lee, Derek Norris, Robert V. Moquin, James Lin, Zhongqi Shen, Kamelia Behnia, Ramesh Padmanabha, Lynda S. Carter, Stephen Castaneda, Lyndon Cornelius, Arthur M. Doweyko, Craig R. Fairchild, John T. Hunt, Ivan Inigo, Amrita Kamath, David Kan, Punit Marathe, Suhong Pang, Sidney Pitt, Gary Schieven, Kim McIntyre, David Shuster, Kathleen Gillooly, Robert Schmidt, John Tokarski, Mei-Li Wen, Robert Borzilleri, John Wityak, Joel C Barrish | |
| 2:50 PM | 296 | Discovery and SAR of a boron-containing clinical molecule (AN-2690) for topical onychomycosis treatment Yong-Kang Zhang, Stephen J. Baker, Tsutomu Akama, Agnes Lau, Vincent Hernandez, Huchen Zhou, Weimin Mao, MRK. Alley, Virginia Sanders, Jacob J. Plattner | |
| 3:10 PM | 297 | Novel, potent and bioavailable CCR5 chemokine receptor small-molecule antagonists for HIV therapy: Scaffold discovery and addressing hERG ion channel affinity in the process of optimizing potency and bioavailability Wieslaw Kazmierski, Don L. Anderson, Chris J. Aquino, Neil Bifulco, Larry R Boone, Eric E. Boros, Brian A. Chauder, Pek Y. Chong, Maosheng Duan, Robert G. Ferris, Terrence P. Kenakin, Cecilia S. Koble, Daniel G. Lang, Ed McLean, Margaret S. McIntyre, Jennifer P. Peckham, Andrew Spaltenstein, Angilique C. Svolto, James B. Thompson, Hanbiao Young, Michael K. Youngman, Patricia J. Wheelan | |
| 3:30 PM | 298 | Discovery, synthesis and optimization of a new series of selective HIV integrase inhibitors leading to MK-0518 currently in Phase III clinical trial for treatment of HIV/AIDS Vincenzo Summa | |
| 3:50 PM | 299 | Discovery and optimization of orally bioavailable leukotriene A4 hydrolase inhibitors for the treatment of myocardial infarction Vincent Sandanayaka, Bjorn Mamat, Peng Yu, Louis Bedell, Lei Zhao, Nikhil Bhagat, Jennifer Winger, Michael Krohn, Monica Keyvan, Pushpa Chandrasekar, Li-Ming Zhou, Rama Mishra, Emmanuel Onua, Jun Zhang, Guðrún Halldórsdóttir, Heiða Sigþórsdóttir, Fanney Stefánsdóttir, Guðmundur Sigþórsson, Þorkell Andrésson, Mitch Friedman, David Zembower, Mark G Gurney, Jasbir Singh | |
| 4:10 PM | 300 | Inhibitors of HCV NS5B polymerase: Synthesis and biological characterization of unsymmetrical dialkyl-hydroxynaphthalenoyl-benzothiadiazines Daniel P. Larson, David W. A. Beno, David A. Betebenner, Todd D. Bosse, John F. Darbyshire, Brian E. Green, Wenping He, Lisa E. Hernandez, Douglas K. Hutchinson, Wen W. Jiang, Warren M. Kati, Dale J. Kempf, Larry L. Klein, William Kohlbrenner, A. Chris Krueger, Jinrong Liu, Liu Yaya, Sherie V. Masse, Keith F. McDaniel, Tim Middleton, Akhteruzzaman Molla, Debra A. Montgomery, Todd W. Rockway, Kent D. Stewart, Vincent P. Stoll, Patricia Stuart, Rolf Wagner | |
| 4:30 PM | 301 | ABT-869, an orally active multi-targeted receptor tyrosine kinase inhibitor Yujia Dai | |
Symposium Grid -- Division of Medicinal Chemistry -- Session Listing
Symposium Grid -- Drug Discovery -- Session Listing
The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006