| MEDI | Monday, 11 September 2006 | ||
9:00 AM-12:15 PM Moscone Center -- Room 103, Oral | |||
Hepatitis C Inhibitors | |||
| Organizers: | Peter Wipf Srikanth Venkatraman | ||
| 9:00 AM | Introductory Remarks | ||
| 9:05 AM | 268 | Allosteric non-nucleoside inhibitors of HCV RNA polymerase (NS5B) Christopher J. Burns | |
| 9:45 AM | 269 | From R1479 to R1626: Optimization of a nucleoside inhibitor of NS5B for the treatment of hepatitis C David B. Smith, Joseph A. Martin, Steven Swallow, Mark Smith, Ann Kaiser, Calvin Yee, Maia Crowell, Woongki Kim, Keshab Sarma, Isabel Najera, Wen-Rong Jiang, Sophie Le Pogam, Sonal Rajyaguru, Klaus Klumpp, Vincent Leveque, Han Ma, Yaping Tu, Rebecca Chan, Michael Brandl, Tom Alfredson, Xiaoyang Wu, Raj Birudaraj, Tony Tran, Nick Cammack | |
| 10:20 AM | 270 | Discovery and optimization of 3-(1,1-dioxo-2H-(1,2,4)-benzothiadiazin-3-yl)-4-hydroxy-2(1H)-quinolinones, potent inhibitors of hepatitis C virus RNA-dependent RNA polymerase Rosanna Tedesco, Antony N. Shaw, Ramesh Bambal, Deping Chai, Nestor O. Concha, Michael G. Darcy, Dashyant Dhanak, Duke M. Fitch, Adam Gates, Dina L. Halegoua, Chao Han, Glenn A. Hofmann, Victor K. Johnston, Arun C. Kaura, Nannan Liu, Richard M. Keenan, Juili Lin-Goerke, Robert T. Sarisky, Kenneth J. Wiggall, Michael N. Zimmerman, Kevin J. Duffy | |
| 11:00 AM | 271 | HepDirect® prodrugs of 2'-methyladenosine for liver-targeted therapy of hepatitis C Scott J. Hecker, K. Raja Reddy, Paul D. van Poelje, Zhili Sun, V. Reddy Mali, Wenjian Huang, Vaibhav Varkhedkar, James Fujitaki, Michael Insko, Douglas Krutil, Bert Chi, David B. Olsen, Kenneth A. Koeplinger, Serge H. Boyer, David Linemeyer, Malcolm MacCoss, Mark D. Erion | |
| 11:35 AM | 272 | Challenges toward the discovery of SCH 503034: A potential therapeutic agent for treatment of hepatitis C viral infection Ashok Arasappan, F. Bennett, S. L. Bogen, Kevin X Chen, Edwin Jao, Y-T. Liu, R. G. Lovey, T. Parekh, R. E. Pike, Patrick Pinto, B. Santhanam, S. Venkatraman, A. K. Saksena, V. Girijavallabhan, J. Pichardo, N. Butkiewicz, B. Malcolm, S Agarwal, A. Hart, R. Liu, Xiao Tong, B. Baroudy, K-C. Cheng, A. Prongay, V. Madison, J. Piwinski, A. K. Ganguly, F. G. Njoroge | |
Symposium Grid -- Division of Medicinal Chemistry -- Session Listing
Symposium Grid -- Drug Discovery -- Session Listing
The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006