| MEDI | Sunday, 10 September 2006 | ||
7:00 PM-9:00 PM Moscone Center -- Hall D, Poster | |||
General Poster Session | |||
| Sponsored by Eli Lilly | |||
| Organizer: | David P. Rotella | ||
| 22 | Ceramide and its inhibitor: Syntheses and applications Shang-U Kim, Shehzad H. Ayub, Robin Polt | ||
| 23 | Synthetic approaches for Fumonisin B1 and B2 Shang-U Kim, Shehzad H. Ayub, Robin Polt | ||
| 24 | Suggested biosynthetic pathway of tunicate-derived benzopolysulfanes David Aebisher, Edyta M. Brzostowska, Mahendran Adaickpillai, Alexander Greer | ||
| 25 | Synthesis of tritiated CT-100, a small molecule inhibitor of microtuble formation, for use in determining binding kinetics Brianne S. Raccor, Charitha Madiraju, Raghavan Balachandran, Pui Kai Li, Billy W. Day | ||
| 26 | Synthesis of fluorinated tetraphenylporphyrins for potential use in photodynamic therapy Kip Conner, Valentina Tan, Meden Isaac, Ursula Simonis | ||
| 27 | Design of glutathione transferase-activated nitric oxide-releasing prodrugs as anticancer agents Thomas C. Wilde, Brett M. Showalter, Joseph E. Saavedra, Paul J. Shami, Kenneth D. Tew, Danyelle M. Townsend, Xinhua Ji, Larry K. Keefer | ||
| 28 | Synthesis of Nordihydroguaiaretic analogs and their anti-cancer properties Joseph E. Blecha, Jennifer Chow, Marc O. Anderson, Jack Youngren, Clifford E. Berkman | ||
| 29 | Prenyl monophosphate prodrugs as Farnesyltransferase and Geranylgeranyltransferase I inhibitors Michelle Maynor, Michelle Clark, Sarah A. Reigard, Richard F. Borch, Richard A. Gibbs | ||
| 30 | Resveratrol analogs as therapeutics for cancer Justin J. Heynekamp, Lorraine M. Deck, Lucy A. Hunsaker, David L. Vander Jagt | ||
| 31 | Synthesis and singlet oxygen generation of hydroxy-branched porphyrins for potential photosensitizers Ke Feng, Xiu R. Bu | ||
| 32 | Dual-targeting taxoid anticancer drug conjugates Stanislav Jaracz, Iwao Ojima | ||
| 33 | DNA cleavage chemistry of pyridine-based heterocyclic skipped aza-enediynes: Deoxyribosyl hydrogen atom abstraction and guanine oxidation Bodin Tuesuwan, Sean M. Kerwin | ||
| 34 | Discovery and development of benzocyclohexene, -heptene and –octene compounds as potential vascular disrupting agents Madhavi Sriram, Nathan Grohmann, John Hall, Kevin G. Pinney | ||
| 35 | Altering the substrate specificity of the Baeyer-Villiger type monooxygenase mtmOIV to produce new analogs of the anticancer agent Mithramycin Miranda Beam, Jürgen Rohr | ||
| 36 | Structure-activity relationship study and in vivo evaluation of a potent and specific peptidomimetic ligand of alpha4 beta1 integrin Ruiwu Liu, Li Peng, Mirela Andrei, Greg W. Bocash, Kit S. Lam | ||
| 37 | G-quadruplex binding agents: 4-Hydroxybenzo(h)quinoline derivatives Jennifer. Baltz, Hanumantharao Paritala | ||
| 38 | Studies of Echinacea on HeLa and MCF-7 cancer cell lines Jeremy Jensen, Fathi T. Halaweish | ||
| 39 | Discovery of potent indole and indolizine derivatives displaying cytotoxicity against multidrug resistant cancer cell lines David James, Keizo Koya, Hao Li, Shoujun Chen, Zhiqiang Xia, Weiwen Ying, Yaming Wu, Lijun Sun | ||
| 40 | The sigma-2 selective tropane analog RHM-138 induces apoptosis In EMT-6 breast cancer cells Justin Rothfuss, Chenbo Zeng, Suwanna Vangveravong, Wenhua Chu, Zhude Tu, Richard Hotchkiss, Katherine C. Chang, Robert H Mach | ||
| 41 | Applications of RNAi against cancer-associated genes Scott E. Martin, Tamara L. Jones, Natasha J. Caplen | ||
| 42 | Synthesis, metal binding, and cytotoxicity of UK-1 analogs Mireya L. Rodriguez, Sean M. Kerwin | ||
| 43 | Pro-drugs of ARQ 501: Designs suitable for other carbonyl-containing drugs and candidates Jean-Marc Lapierre, Manish Tandon, Yanbin Liu, Hui Wu, E. Kelleher, Dasharatha Reddy, Yinglin Han, Steve Couture, Sapna Makhija, Zhiwei Jiang, Mark A. Ashwell | ||
| 44 | Targeted delivery of ARQ 501 to tumors using novel chemical linking strategies Manish Tandon, Jean-Marc Lapierre, Yanbin Liu, Hui Wu, Erika Volckova, Sapna Makhija, Ron Savage, Zhiwei Jiang, Ying Si, Mark A. Ashwell | ||
| 45 | Chemical synthesis of C-2 taxoids and their tubulin binding abilities and antitumor activities Chun-Gang Yang, Ruth Matesanz, Ana Alcaraz, Lei Wang, Xuan Li, Isabel Barasoain, Ronghua Liu, Frances J. Sharom, James P. Snyder, J. Fernando Díaz, Wei-Shuo Fang | ||
| 46 | Discovery and pre-clinical development of a novel inhibitor of oncogenic B-Raf Prabha N. Ibrahim, Jiazhong Zhang, Hanna Cho, Shumeye Mamo, Ryan Bremer, Samuel Gillette, Abhinav Kumar, Daniel Fong, Weiru Wang, Yong-Liang Zhu, Adhirai Marimuthu, Yoshihisa Suzuki, Billy Lam, Julie Rice, James Tsai, Calvin Settachatgul, Rafe Shelloe, John Cantwell, Brain West, Ben Powell, Gaston Habets, Chao Zhang, D. Rick Artis, Peter Hirth, Gideon Bollag | ||
| 47 | Synthesis and biological evaluation of pancratistatin analogs with the truncated cyclitol portion of the molecule Madhuri Manpai, Alexander Kornienko | ||
| 48 | Successful delivery of siRNA to human chronic myelogenous leukemia cells by cobalamin-mediated endocytosis Randy Y. Adachi, Charles B. Grissom | ||
| 49 | Synthesis and biological evaluation of heterocyclic analogs of podophyllotoxin Madhuri Manpadi, Alexander Kornienko, Elena Rozhkova, Igor V. Magedov | ||
| 50 | Characterization of the “R” binding site of P-glycoprotein: Using novel chalcogenoxanthylium tetramethylrosamine analogs for the stimulation of ATPase activity Michael K. Gannon II, Gregory Tombline, David J Donnelly, Jason J. Holt, Youngjae You, Mao Ye, Cara L. Nygren, Michael R. Detty | ||
| 51 | Development of a novel carbohydrate microarray and its application in cancer diagnostics and therapeutics Joseph C. Manimala, Tim Roach, Zhitao Li, Jeffrey C. Gildersleeve | ||
| 52 | Synthesis of asymmetric, heavy chalcogen tetramethylrosamine derivatives: Micromolar inhibition at the “R” site of P-Glycoprotein Jason J. Holt, Gregory Tombline, Michael R. Detty | ||
| 53 | PDT efficiency of pheophorbide a analogs upon conjugating with cyclo(RGDfK) Suresh K. Pandey, Shipra Dubey, Xiang Zheng, Yihui Chen, Carrie A. Batt, Janet Morgan, Michael J. Ciesielski, Munnawar Sajjad, Hani A. Nabi, Robert A. Fenstermaker, Allan R. Oseroff, Ravindra K. Pandey | ||
| 54 | Design and synthesis of a folate receptor-targeted chemotherapeutics: Folic acid conjugate of desacetylvinblastine hydrazide (EC 145) Iontcho R. Vlahov, Hari Krishna R. Santhapuram, Paul J. Kleindl, Stephen J. Howard, Katheryn M. Stanford, Christopher P. Leamon | ||
| 55 | Synthesis of 1-/2-substituted-[1, 2, 3]triazolo[4, 5-g]phthalazine-4, 9-diones and evaluation of their cytotoxicity and DNA topoisomerase inhibitory activity Hee-Kyung Rhee, Hyen Joo Park, Sang Kook Lee, Chong-Ock Lee, Hea-Young Park Choo | ||
| 56 | Tetracyclic pyrazoles, open analogs and derivatives: From 7-Chloro-1,4,5,10-tetrahydro-1,2,10-triaza-cyclopenta[a]fluorene to three new scaffolds Daniela Berta, Simona Bindi, Alexander Cameron, Giovanni Cervi, Daniele Fancelli, Ronald D Ferguson, Barbara Forte, Sergio Mantegani, Maria Menichincheri, Maurizio Pulici, Ermes Vanotti, Mario Varasi, Paola Vianello, Fulvia Roletto, Aurelio Marsiglio | ||
| 57 | Design, synthesis and evaluation of novel compounds for use in the prodrug approach to cancer chemotherapy Gavin D. Couch, Christopher J. Moody | ||
| 58 | Design and synthesis of ring-fused and conformationally restrained epothilone analogs Weiqiang Zhan, Yi Jiang, Susan Bane, Abhijit Banerjee, Dennis C. Liotta, James P. Snyder | ||
| 59 | EPR and molecular modeling studies of spin-labeled DNA antisense agents Robyn R. Ayscue, Peter M. Gannett | ||
| 60 | Synthesis, cytotoxicity, and DNA topoisomerase inhibitory activity of benzonaphthofurandione and benzofuroquinolinedione derivatives Hee-Kyung Rhee, Hyen Joo Park, Sang Kook Lee, Chong-Ock Lee, Hea-Young Park Choo | ||
| 61 | Synthesis and cytotoxic activity of 1-En-3-one lupane triterpenoids Ali Koohang, Ze-Qi Xu, Erika L. Szotek, Nathan D. Majewski, Aye Aye Mar, David A. Eiznhamer, Michael T. Flavin | ||
| 62 | Novel human lipoxygenases inhibitors discovered using virtual screening with homology models Victor A. Kenyon, Ilya Chorny, Wendy J. Carvajal, Theodore R. Holman, Matthew P. Jacobson | ||
| 63 | Structure activity relationship studies of flavonoids as potent inhibitors against 12-hLO, 15-hLO and 15-hLO-2 Rachana V. Ohri, Vasquez-Martinez Yesseny, Silvia Sepúlved-Boza, Theodore Holman | ||
| 64 | pH-Sensitive biotinylated dendritic MRI probe to improve detection of liver tumors Md. Meser Ali, Mark D. Pagel | ||
| 65 | Chemical genetics approach to breast cancer therapy Kedra C Cyrus, Yang-eon Kim, Kyung-Bo Kim | ||
| 66 | Design, synthesis, and evaluation of novel bimodal ligands for radioimmunotherapy of cancer Hyun-Soon Chong, Thien Le, Phuong Bui, Noah Birch, Xiang Wang, Katherine Hammes | ||
| 67 | Fluorous-phase synthesis of minor groove binding agents related to distamycin Jennifer. Baltz, Sreeman K. Mamidyala | ||
| 68 | Synthesis of the carcinogenic C8–carboxyphenyl & C8–hydroxymethylphenyl guanine adducts and their effect on DNA conformation Vorasit Vongsutilers, Peter M. Gannett | ||
| 69 | Optimizing lead anologs for activated a4b1 integrin Richard D. Carpenter, Mark J. Kurth, Kit S. Lam | ||
| 70 | Synthesis and bioevaluation of novel theophylline-dendrimer conjugates Xingyi Yang, Minghui Chai, Ping Zhou, Shengxiang Qiu | ||
| 71 | Design, synthesis and testing of novel styryl benzyl sulfones as potent anti-cancer agents Muralidhar R Mallireddigari, Venkat R Pallela, Stephen C Cosenza, Stanley C Bell, Balaiah Akula, Vinaykumar Billa, Revathi Patti, E. Premkumar Reddy, MV. Ramana Reddy | ||
| 72 | Synthesis and cytotoxic evaluation of novel thiazolo[5,4-b]quinoline derivatives Alfonso Lira-Rocha, Susana Vázquez-Olvera, Marco A. Loza-Mejía, Angelina Quintero, José D. Solano, Adriana Camacho, Sergio Molina | ||
| 73 | Antiproliferative effect of select plant extracts on different cancer cells Ipek Goktepe, Norma Sneed, Bonita Milford, Mohamed Ahmedna | ||
| 74 | Evaluation of efficient intracellular release of anticancer agents from tumor-targeting delivery system Shuyi Chen, Xianrui Zhao, Jin Chen, Iwao Ojima | ||
| 75 | First 3D pharmacophore modeling of androgen receptor down-regulating agents (ARDAs): Discovery of potent anti-prostate cancer agents Vincent C. O. Njar, Puranik Purushottamachar, Aakanksha Khandelwal, Neha Maheshwari, Pankaj Chopra, Lalji K. Gediya | ||
| 76 | Phosphoramidate derivatives of hydroxy steroids as inhibitors of prostate-specific membrane antigen Lisa Yong Wu, Helen Page, Yoko Toriyabe, Marc O. Anderson, Clifford E. Berkman | ||
| 77 | Small α-helix mimetics for the inhibition of the estrogen receptor-coactivator interaction Jorge Becerril, Andrew D. Hamilton | ||
| 78 | Novel vitamin D receptor (VDR) and androgen receptor (AR) ligands with diphenylmethane skeleton Shinnosuke Hosoda, Aya Tanatani, Ken-ichi Wakabayashi, Kazuo Nagasawa, Hiroyuki Miyachi, Yuichi Hashimoto | ||
| 79 | New 3-beta-halopropionyloxi-4,16-pregnadiene-6,20-dione derivatives as 5-alpha-reductase inhibitors Eugene A. Bratoeff | ||
| 80 | Novel non-steroidal/non-anilide type androgen antagonists effective toward mutated androgen receptor Aya Tanatani, Ken-ichi Wakabayashi, Hiroyuki Miyachi, Yuichi Hashimoto | ||
| 81 | Novel retinoid antagonists bearing trifluoromethyl groups Hiroyuki Kagechika, Michimasa Maeda, Tomoya Hirano, Emiko Kawachi, Yuichi Hashimoto | ||
| 82 | Novel C-17-heteroaryl steroids as potential inhibitors of CYP17 Vincent C. O. Njar, Jorge A. R. Salvador, Vânia M. A. Moreira, Tadas Sean Vasaitis | ||
| 83 | Synthesis and activities of imidazolyl derivatives as novel farnesyltransferase inhibitors Yeelana Shen, Philip G. Kasprzyk, Gregoire Prevost, Jesse Z. Dong | ||
| 84 | SAR studies of potent antitumor agent FR901464 Brian J. Albert, Nancy L. Czaicki, Kazunori Koide | ||
| 85 | Synthesis and cytotoxicity of Sansalvamide A derivatives in drug resistant colon cancers Katerina Otrubova, Po-Shen Pan, Thomas J. Styers, Ahmet Kekec, Rodrigo Rodriguez, Joseph D. Brown, Stephanie Lapera, Suchitra Ravula, Erin Singh, Chung-Mao Pan, Emily Parry, Crystal Sanchez, Shelli R. McAlpine, Kathleen L. McGuire | ||
| 86 | Small molecule apoptosis inducer in multiple myeloma cell lines Ramzi Ayyad, Kaapjoo Park, Derek C. Cole, Joseph R. Stock, Jun Xu, Chao-Pei Betty Chang, Wenshan Hao | ||
| 87 | Function oriented synthesis: Design, synthesis, and biological evaluation of novel chemotherapeutic agents in the bryolog series Paul A. Wender, Jeremy L. Baryza, Joshua C. Horan, Vishal A. Verma | ||
| 88 | Ligands for the TRP-M8 receptor found in prostate cancer cells Lok Him Yu, Chi Ching Joyce Leung, Xiaoliu Guo, Ahamindra Jain | ||
| 89 | Pyrazolo[1,5-a]pyrimidin-7-yl phenyl amides as novel anti-proliferative agents for p21 deficient cells: Structure activity relationships of analogs with amide modifications Fuk-Wah Sum, Lijing Chen, Lane Wooder, Eric Honores, Daniel Wang, Dennis Powell, Miriam Miranda, Sridhar Rabindran | ||
| 90 | A novel duocarmycin-analog based pro-drug, Delivered as an antibody drug conjugate for targeted cancer therapy Liang Chen, Sanjeev Gangwar, Chin Pan, Chetana Rao, Bilal Sufi, Sharon Boyd, Mary Huber, Peter Sattari, Mary Do, Rory Dai, Colin Chong, Carol Soderberg, Hao Li, Haichun Huang, Haibin Chen, Lynae Green, Janette Sung, David Passmore, Vangipuram Rangan, Vincent Guerlavais, Killian Horgan, Nik Sharkov, Krista Heaton, Tom Kempe, Mohan Srinivasan, Shrikant Deshpande, Pina Cardarelli, David J. King | ||
| 91 | Characterizing binding interactions of the PH1 domain of AFAP-110: A precursor to anticancer therapeutic design John E Jett, Daniel C Flynn, Henry G Zot, Peter M. Gannett | ||
| 92 | Discovery of potent small molecule inhibitors of the MDM2-p53 interaction through pharmacophore-based and structure-based database screening Yipin Lu, Zaneta Nilolovska-Coleska, Su Qiu, Sanjeev Kumar, Wei Gao, Xueliang Fang, Dongguang Qin, Shaomeng Wang | ||
| 93 | MDM2 inhibitory peptides: Side chains cyclization as a method of stabilization of the biologically active helical conformation Krzysztof Krajewski, Zaneta Nikolovska-Coleska, Shaomeng Wang, Peter P. Roller | ||
| 94 | Design, synthesis and evaluation of spirooxindoles as potent and specific non-peptide small-molecule inhibitors of the MDM2-p53 interaction Dongguang Qin, Ke Ding, Guoping Wang, Zaneta Nikolovska-Coleska, Yipin Lu, Su Qiu, Sanjeev Kumar, Wei Gao, Jeanne Stuckey, Krzysztof Krajewski, Peter Roller, Shaomeng Wang | ||
| 95 | Apoptotic pathway induced by HA 14-1, a small-molecule antagonist for Bcl-2 protein Chengguo Xing, Jignesh M Doshi, Defeng Tian, Sadiya N Addo | ||
| 96 | Pharmacophore- and structure-based approaches to the development of small molecule inhibitors for Bcl-2 family proteins and MAP kinases Xiyun Zhang, Michele F. Rega, Jui-Wen Huang, John Stebbins, Barbara Becattini, Maurizio Pellecchia | ||
| 97 | Design, synthesis and evaluation of a new class of potent and cell-permeable small molecule inhibitors of Bcl-2 and Mcl-1 Guozhi Tang, Ke Ding, Jie Guo, Zaneta Nikolovska-Coleska, Chao-Yie Yang, Renxiao Wang, Jianting Long, Su Qiu, Sanjeev Kumar, Wei Gao, Jeanne Stuckey, Krzysztof Krajewski, Sheng Jiang, Peter P. Roller, Shaomeng Wang | ||
| 98 | Structure-based discovery of small molecule inhibitors of XIAP Yipin Lu, Zaneta Nilolovska-Coleska, Su Qiu, Shaomeng Wang | ||
| 99 | Theoretical design of a novel series of enediynes containing metal center Edyta M. Brzostowska, Roald Hoffmann | ||
| 100 | Indenopyrazoles: Potent, broad-spectrum cyclin dependent kinase inhibitors Christopher J. Oalmann, Nick Bockovich, Maureen Caligiuri, Faith Kaplan, Jianxing Huang, Arthur Kluge, Lou Lamphere, Mohamud Mohamud, Judson Richard, Ram Siya, Katya Tsaioun, Shaoshan Wang, Zhonggou Wang | ||
| 101 | Discovery of PF-371989: A novel Tie2 kinase inhibitor Susan LaGreca, Joel T. Arcari, Gary Borzillo, Michael J Chen, Tracey Clark, Bruce Cohen, Marcus Ewing, William M. Hungerford, Catherine Soderstrom, Shefali Kakar, Aaron Kanter, Lissie Knauth, Yong Lu, Luis Martinez-Alsina, Matthew A Marx, Nandini Patel, Carl Thompson, Norma Tom, Matt Wessel, Patrick W Vincent | ||
| 102 | Synthetic approaches to novel analogs of Tie-2 kinase inhibitors Joel T. Arcari, Michael J Chen, William Hungerford, Nandini Patel, Matthew A Marx, Susan LaGreca, Luis Martinez-Alsina, Matthew Wessel, Stephen Anderson, Jon Bordner, Gary Borzillo, Tracey Clark, Bruce Cohen, Marcus Ewing, Catherine Soderstrom, Shefali Kakar, Aaron Kanter, Lissie Knauth, Carl Thompson, Norma Tom, Ivan Samardjiev, Patrick W Vincent | ||
| 103 | Design and synthesis of selective Tie-2 inhibitors Nandini Patel, Joel T. Arcari, Gary Borzillo, Michael J Chen, Tracey Clark, Bruce Cohen, Marcus Ewing, William M. Hungerford, Shefali Kakar, Aaron Kanter, Lissie Knauth, Susan LaGreca, Yong Lu, Luis Martinez-Alsina, Matthew A Marx, Catherine Soderstrom, Carl Thompson, Norma Tom, Matt Wessel | ||
| 104 | Synthesis, structure-activity relationships, and mechanism of action of novel indirubin derivatives as potent anti-proliferative agents with CDK2 inhibitory activities Yong-Chul Kim, Isak Im, Soo Jung Choi, Eun Sil Lee, Sang Kook Lee | ||
| 105 | Discovery and optimization of potent ACK1 inhibitors – Part I: 4-Amino substitution is important for potency improvement Jinqian Liu, Rajiv Sharma, Sarah Lively, Simon Burkitt, Andrew Clase, Chris Farthing, XianYun Jiao, David Kopecky, Frank Kayser, Stephen Shuttleworth, Martin Harrison, Paul Faulder, Shyun Li, Holger Wesche, Rommel Mallari, Ellyn Farrelly, Shou-Hua Xiao, Jinsong Liu, Zhulun Wang, Juan Jaen | ||
| 106 | Discovery and optimization of potent ACK1 inhibitors – Part II: Structural modification of the furanopyrimidine core David Kopecky, Simon Burkitt, Andrew Clase, Ellyn Farelli, Chris Farthing, Paul Faulder, David Frenkel, Martin Harrison, Juan Jaen, XianYun Jiao, Frank Kayser, Shyun Li, Jinqian Liu, Jinsong Liu, Sarah Lively, Rajiv Sharma, Astrid Strelow, Edward van der Horst, Zhulun Wang, Holger Wesche, Shou-Hua Xiao | ||
| 107 | Discovery and optimization of potent ACK1 inhibitors – Part III: Selected 4-amino substitution affords very potent inhibitors Sarah Lively, Simon Burkitt, Mario Cardozo, Andrew Clase, Ellyn Farelli, Chris Farthing, Paul Faulder, Martin Harrison, Juan Jaen, XianYun Jiao, Frank Kayser, David Kopecky, Shyun Li, Jinqian Liu, Jinsong Liu, Rommel Mallari, Rajiv Sharma, Astrid Strelow, Edward van der Horst, Zhulun Wang, Holger Wesche, Shou-Hua Xiao | ||
| 108 | A new binding mode for inhibitors in Src reminiscent of Gleevec in Abl Joel Renick, Andrew McPherson, Kathy Barrett, Jianguo Cao, Richard Fine, Colleen Gritzen, John Hood, Xinshan Kang, Chi-Ching Mak, Glenn Noronha, Ved P. Pathak, Richard Soll, Ute Splittgerber, Binqi Zeng | ||
| 109 | Validation of novel binding interaction for tyrosine kinases via crystal structures of low nM Src inhibitors: Implications for structure based drug design Ved P. Pathak, Andrew McPherson, Kathy Barrett, Jianguo Cao, Richard Fine, Colleen Gritzen, John Hood, Xinshan Kang, Boris Klebansky, Dan Lohse, Chi-Ching Mak, Ismail Moarefi, Glenn Noronha, Joel Renick, Richard Soll, Ute Splittgerber, Binqi Zeng, Hong Zhu | ||
| 110 | Synthesis of 3-(substituted-benzylidene)-1, 3-dihydro-indolin derivatives and investigation of their roles against human protein kinase CK2 Sureyya Olgen, Claudia Götz, Joachim Jose | ||
| 111 | Synthesis and characterization of 2,4-diaryl-2,5-dihydropyrrole-2-(3'phenol) inhibitors of the mitotic kinesin KSP Robert M. Garbaccio, Edward S. Tasber, Mark E. Fraley, George D. Hartman, Robert B. Lobell, Carolyn A. Buser, Weikang Tao, Hans E. Huber, Nancy E. Kohl, Youwei Yan, Lawrence C. Kuo, Maricel Torrent, Thomayant Prueksaritanont, Cathy Shu, Donald Slaughter | ||
| 112 | Synthesis and biological evaluation of (3Z)-3-quinolin-2(1H)-ylidene-1,3- dihydro-2H-indol-2-one derivatives as novel vascular endothelial growth factor-2 tyrosine kinase inhibitors Kiyohiro Samizu, Hiroyuki Hisamichi, Akira Matsuhisa, Itsuro Shimada, Takanori Koike, Isao Kinoyama, Masahiko Hayakawa, Shunichiro Matsumoto, Nobuaki Taniguchi, Kiyoshi Yahiro, Naoko Katayama, Yukitaka Ideyama, Mayumi Yamano, Sadao Kuromitsu, Katsunori Tajinda, Nobuaki Amino, Minoru Okada, Makoto Takeuchi, Mitsuaki Ohta | ||
| 113 | Synthesis and SAR of cyanoguanidine and nitroethylene containing thiophene carboxamides as c-Kit inhibitors Bijoy Panicker, Andrew Crew, Mark Bittner, Linda Castaldo, Arlindo Castelhano, Andrew Cooke, Dong Hanqing, Andrew Garton, Jennifer Kahler, An-Hu Li, Li Qiu, Alun Smith, Lawrence Tardibono, Qinghua Weng, Tao Zhang | ||
| 114 | 3-Amino benzo[d]isoxazoles as novel multitargeted receptor tyrosine kinase inhibitors Zhiqin Ji, Asma A. Ahmed, Daniel H. Albert, Jennifer J. Bouska, Peter F. Bousquet, George A. Cunha, Keith B. Glaser, Eric F. Johnson, Jun Guo, Junling Li, Patrick A Marcotte, Maria D. Moskey, Lori J. Pease, Nirupama B. Soni, Kent D. Stewart, Paul Tapang, Melinda S. Yates, Steven K. Davidsen, Michael R. Michaelides | ||
| 115 | SAR of 3-(1H-Benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of IGF-1R Kinase: Balancing oral exposure and Cyp inhibition Xiaopeng Sang, Kurt Zimmermann, Mark D. Wittman, Mark G. Saulnier, Upender Velaparthi, David Langley, David B. Frennesson, Peiying Liu, Joan Carboni, Aixin Li, Ann Greer, Zheng Yang, Praveen Balimane, Dolatrai M. Vyas | ||
| 116 | Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors: Design, synthesis and biological activity Damian O. Arnaiz, Judi Bryant, Yuo-Ling Chou, Paul M. Hrvatin, Imadul Islam, Monica J. Kochanny, Wheeseong Lee, Gary B. Phillips, Hongyi Yu, Marc Adler, Marc Whitlow, Dao Lentz, Mark A. Polokoff, James M. Wu, Daguang Zhu, Richard I. Feldman | ||
| 117 | Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors: Optimization of BX-517 Imadul Islam, Damian O. Arnaiz, Greg Brown, Judi Bryant, Yuo-Ling Chou, Paul M. Hrvatin, Monica J. Kochanny, Wheeseong Lee, Gary B. Phillips, Hongyi Yu, Shendong Yuan, Marc Adler, Marc Whitlow, Dao Lentz, Mark A. Polokoff, James M. Wu, Jun Shen, Janette Walters, Elena Ho, Babu Subramanyam, Sandra L. Biroc, Bruno Alicke, Daguang Zhu, Richard I. Feldman | ||
| 118 | Thieno[3,2-c]pyrazoles a new class of Aurora inhibitors Paola Vianello, Simona Bindi, Daniela Berta, Alexander Cameron, Matteo D'Anello, Barbara Forte, Valeria Pittalà, Mario Varasi, Juergen Moll, Fulvia Roletto, Patrizia Carpinelli, Paola Storici, Paolo Cappella, Daniele Fancelli | ||
| 119 | Design and synthesis of target kinase inhibitor library Q. John Yu, Faming Zhang | ||
| 120 | Influence of novel heterocyclic sidechains on the SAR of a series of 3-[6-(4-substituted-piperazin-1-yl)-4-methyl-1H-benzimidazol-2-yl]-1H-pyridin-2-one inhibitors of the IGF-1R kinase David B. Frennesson, Mark G. Saulnier, Charles Struzynski, David Langley, Upender Velaparthi, Peiying Liu, Kurt Zimmermann, Xiaopeng Sang, Francis Y. Lee, Joan Carboni, Aixin Li, Ann Greer, Praveen Balimane, Zheng Yang, Chiehying Chang, John Sack, George L. Trainor, Mark D. Wittman, Dolatrai M. Vyas, Ricardo Attar, Marco Gottardis | ||
| 121 | Src inhibitors with sub nM VEGFR2 activity: Discovery and SAR Elena Dneprovskaia, Andrew McPherson, Kathy Barrett, Jianguo Cao, Richard Fine, Colleen Gritzen, John Hood, Xinshan Kang, Chi-Ching Mak, Glenn Noronha, Ved P. Pathak, Joel Renick, Richard Soll, Binqi Zeng | ||
| 122 | Synthesis and SAR of novel inhibitors of the MLK family Matthew Curry, Thelma S. Angeles, George Gessner, Diane E. Gingrich, Robert L. Hudkins, Jean Husten, Teresa O'Kane, Bethann McKenna, Allison Zulli | ||
| 123 | Design, synthesis and structure activity relationship within a series of 4-amino-thienopyridines, dual KDR/FGFR tyrosine kinase inhibitors Y. Chen, K. Luk, T Flynn, L. McDermott, Omar Morales, P. Rossman, M. Simcox, S-S. So, P Wovkulich, H. Yang, Z. Zhang | ||
| 124 | Design and synthesis of potent small-molecule inhibitors of Stat-3 Jianyong Chen, Zaneta Nikolovska-Coleska, Cindy Gomez, Chao-Yie Yang, Wei Gao, Krzysztof Krajewski, Sheng Jiang, Peter Roller, Shaomeng Wang | ||
| 125 | Design, synthesis, and biological activity of 5,10-dihydro-dibenzo[b,e][1,4]diazepin-11-one based potent, and selective Chk-1 inhibitors Le Wang, Gerard M. Sullivan, Laura Hexamer, Lisa A. Hasvold, Reema Thalji, Magdalena Przytulinska, Zhi-Fu Tao, Gaoquan Li, Zehan Chen, Zhan Xiao, Wen-Zhen Gu, John Xue, Mai-Ha Hui, Philip Metra, Peter Kovar, Haiying Zhang, Chang Park, Kent Stewart, Hing L. Sham, Thomas Sowin, Saul Rosenberg, Nan-Horng Lin | ||
| 126 | Discovery of tricyclic pyrazoles as potent checkpoint-1 kinase inhibitors Yunsong Tong, Akiyo Claiborne, Zhi-Fu Tao, Peter Kovar, Chang Park, Zehan Chen, R. Bruce Credo, Kent D. Stewart, Haiying Zhang, Saul Rosenberg, Hing L. Sham, Thomas Sowin, Nan-Horng Lin | ||
| 127 | Development of substituted indolylindazoles as potent and selective Chek1 kinase inhibitors Justin T. Steen, Mark E. Fraley, Edward Brnardic, George D. Hartman, Youwei Yan, Sanjieev Munshi, Mari Ikuta, Lawrence C. Kuo, Constantine Kreatsoulas, Michael Reilly, Elizabeth Mahan, Steve Stirdivant, Bob Drakas, Eileen Walsh, Kelly Hamilton, Carolyn Buser, Keith Rickert, Weikang Tao, James Hardwick, Xianzhi Mao, Steve Beck, Robert B. Lobell, Laura Sepp-Lorenzino | ||
| 128 | Structure-based design, synthesis and biological evaluation of macrocyclic Chk1 Inhibitors Zhi-Fu Tao, Le Wang, Yunsong Tong, Gaoquan Li, Magdalena Przytulinska, Gerard Sullivan, Zehan Chen, Zhan Xiao, Wendy Gu, John Xue, Mai-Ha Bui, Philip Merta, Peter Kovar, Haiying Zhang, Chang Park, Kent D. Stewart, Hing L. Sham, Thomas Sowin, Saul H. Rosenberg, Nan-Horng Lin | ||
| 129 | Development of substituted indolylquinolinones as potent Chek1 kinase inhibitors Shaei Huang, Rob Garbaccio, Mark Fraley, Justin T. Steen, George Hartman, Youwei Yan, Sanjieev Munshi, Mari Ikuta, Lawrence Kuo, Constantine Kreatsoulas, Michael Reilly, Elizabeth Mahan, Steve Stirdivant, Bob Drakas, Eileen Walsh, Kelly Hamilton, Carolyn Buser, Keith Rickert, Weikang Tao, James Hardwick, Xianzhi Mao, Steve Beck, Rob Lobell, Laura Sepp-Lorenzino | ||
| 130 | Novel thieno[3,2-b]pyridine scaffold based inhibitors of the c-Met and VEGFR receptor family Stephen Claridge, Franck Raeppel, Marie-Claude Granger, Naomy Bernstein, Oscar Saavedra, Lijie Zhan, David Llewellyn, Amal Wahhab, Robert Déziel, Gabi Rahil, Normand Beaulieu, Hannah Nguyen, Isabelle Dupont, Annie Barsalou, Carole Beaulieu, Ian Chute, Serge Gravel, Marie-France Robert, Sylvain Lefebvre, Marja Dubay, James Wang, Jeffrey Besterman, A. Robert Macleod, Arkadii Vaisburg | ||
| 131 | 4-Phenyl-6H-2,6-diaza-as-indacene-1,3-dione inhibitors of the G2/M DNA damage checkpoint kinase Wee1 R. John Booth, Derek J. Sheehan, Daniel F. Ortwine, Peter L. Toogood, Alexander J. Bridges, William A. Denny, K Hook, Alan J Kraker, Ho Lee, Brian D Palmer, John Quin III, Chris Squire | ||
| 132 | Probing the ATP-binding site of heat shock protein 90 (Hsp90) with synthetic macrolactones: Synthesis of simple analogs of radicicol as potent Hsp90 inhibitors Nicolas Proisy, Christopher J. Moody | ||
| 133 | Structure-activity relationships of small molecule inhibitors of Hsp90 M. Kyle Hadden, Stephanie A. Hill, Steven M. Schebler, Robert L. Matts, Brian S. J. Blagg | ||
| 134 | Structure-activity relationship studies of libraries of potent Hsp90 inhibitors Yung-tzung Huang, Brian Blagg | ||
| 135 | Paper Withdrawn | ||
| 136 | Hsp90 inhibitors: A study of coumarin antibiotic derivatives Donna J. Lubbers, Joseph A. Burlison, Brian S. J. Blagg | ||
| 137 | Novobiocin analogs: Development and evaluation of novel small molecule Hsp90 inhibitors Joseph A. Burlison, Donna J. Lubbers, Brian S. J. Blagg | ||
| 138 | 2, 4-Diamino-6-arylthino[2,3-d]pyrimidines as potential dihydrofolate reductase inhibitors Aleem Gangjee, Xilin Zhou, Roy L. Kisliuk, Sherry F. Queener | ||
| 139 | Novel 5-substituted, 2,4-diaminofuro[2,3-d]pyrimidines as potential multi-receptor tyrosine kinases and dihydrofolate reductase inhibitors in single molecules Aleem Gangjee, Lu Lin, Michael Ihnat, Linda A. Warnke, Jessica E. Thorpe, Roy L. Kisliuk | ||
| 140 | Non-classical 5-aryl-furo[2,3-d]pyrimidines and 6-aryl-pyrrolo[2,3-d]pyrimidines as potential dihydrofolate reductase and/or thymidylate synthase inhibitors Aleem Gangjee, Hiteshkumar D. Jain, Sherry F. Queener, Roy L. Kisliuk | ||
| 141 | Design, synthesis, and evaluation of novel 5-substituted, 2,4-diaminofuro[2,3-d]pyrimidines as single agent multireceptor tyrosine kinase and dihydrofolate reductase inhibitors Aleem Gangjee, Wei Li, Michael A Ihnat, Linda A. Warnke, Jesssica E. Thorpe, Roy L. Kisliuk | ||
| 142 | Discovery of novel antitumor antimitotic agents that also reverse tumor resistance Aleem Gangjee, Jianming Yu, Staci N. Keller, Charles D. Smith | ||
| 143 | Synthesis of classical diamino furo[2,3-d] pyrimidine analogs as antifolates Aleem Gangjee, Lei Wang, Larry H. Matherly, Yijun Deng | ||
| 144 | Polyaminohydroxamic acids and polyaminobenzamides the selectively inhibit histone deacetylase 6 Sheeba Varghese, Amy Hacker, Tracey Murray-Stewart, Robert A. Casero, Patrick M. Woster | ||
| 145 | Heterobiaryl hydroxamic acids as potent inhibitors of histone deacetylase (HDAC) possessing significant anti-proliferative cellular activity David E. Clark, Steve Price | ||
| 146 | Synthesis and SAR of N-hydroxy-1,2-disubstituted-1H-benzoimidazol-5-yl-acrylamides as a novel class of histone deacetylase inhibitors Haishan Wang, Niefang Yu, Hongyan Song, Dizhong Chen, Weiping Deng, Pek Ling Lye, Yong Zou, Melvin Ng, Joyce Chang, Eric T Sun, Kanda Sangthongpitag, Xukun Wang, Xiaofeng Wu, Hwee Hoon Khng, Siok Kun Goh, Pauline Yeo, Xin Liu, Evelyn Goh, Lee Sun New, Kantharaj Ethirajulu, Michael Entzeroth | ||
| 147 | Design and synthesis of arylamino-(2-aminophenyl)-benzamides or cinnamides (A) and heteroaryl -N-(2-aminophenyl)-benzamides (B) as a novel class of histone deacetylase inhibitors Nancy Zhihong Zhou, Oscar Moradei, Stéphane Raeppel, Silvana Leit, Sylvie Frechette, Frédéric Gaudette, Isabelle Paquin, Giliane Bouchain, Naomy Bernstein, Franck Raeppel, Oscar Saavedra, Soon Hyung Woo, Arkadii Vaisburg, Marielle Fournel, Ann Kalita, Aihua Lu, Marie-Claude Trachy-Bourget, Pu T. Yan, Jianhong Liu, Zuomei Li, Gabi Rahil, A. Robert Macleod, James Wang, Jeffrey Besterman, Daniel Delorme | ||
| 148 | Synthesis and evaluation of cyclopeptide inhibitors of histone deacetylase Charles M Marson, Stephane Sengmany, Brian Middleton, Jonathan Dines, N Shaun B Thomas | ||
| 149 | The computational search for novel histone deacetylase class I isozymes Emilio Xavier Esposito, Gregory R. Cook | ||
| 150 | Design and synthesis of histone deacetylase 6 selective inhibitors Takayoshi Suzuki, Akiyasu Kouketsu, Yukihiro Itoh, Shinya Hisakawa, Satoko Maeda, Minoru Yoshida, Hidehiko Nakagawa, Naoki Miyata | ||
| 151 | Discovery of second generation farnesyl protein transferase inhibitors Hugh Y. Zhu, Alan B. Cooper, Jagdish Desai, Ronald J. Doll, V. Girijavallabhan, Dinanath Rane, James Wang, Paul Kirschmeier, Ming Liu, W. Robert Bishop, Robert Patton, Linda James, Corey Strickland, Amin Nomeir | ||
| 152 | Alternative route to compound 1: Utilization of an alpha-ketone arylation/oxidation, SNAr and Ullman reaction: An alternative route to Compound 1 Joel Robert Calvin | ||
| 153 | Glycorandomization of colchicine influences cytotoxicity and mechanism of action Aqeel Ahmed, Noël, R Peters, Megan, K Fitzgerald, Jon S. Thorson | ||
| 154 | Evaluating bed stability of a new axial compression packing technology to traditional slurry packed columns for high throughput HPLC preparative purifications Peter C Rahn, Tivadar Farcas, Gareth Friedlander, Joshua Heng, Emmet Welch | ||
| 155 | Synthesis of 5-nitroimidazole derivatives of tert-butyl ester of aminoacids Iwona E. Weidlich, Stanislaw Sobiak | ||
| 156 | Paper Withdrawn | ||
| 157 | Synthesis and evaluation of Estradiol-PEG-DNA alkylation agents using click chemistry Edward Y. Hua, David C. Labaree, Richard B. Hochberg, Robert N. Hanson | ||
| 158 | Series of novel polysulfide diketopiperazines produced by the fungus Fusarium merismoides Hui Y. Yang, Haiyin He, John Hucul, Debbie Roll, Xidong Feng, Wenshan Hao, Jun Xu | ||
| 159 | Substrate activity screening (SAS): A fragment-based method for the rapid identification of nonpeptidic protease inhibitors Andrew W. Patterson, Warren J. L. Wood, Jonathan A. Ellman | ||
| 160 | Soluble guanylyl cyclase activation by a series of aryl disulfanyl dinitrates Adrian C. Nicolescu, Gregory R. J. Thatcher, Brian M. Bennett | ||
| 161 | Design, synthesis, and biochemical evaluation of ribitylaminopyrimidine substrate analogs of lumazine synthase as potential enzyme inhibitors and mechanistic probes Arindam Talukdar, Adelbert Bacher, Markus Fisher, Boris Illarionov, Mark Cushman | ||
| 162 | Polyamine functionalized SPE polymers: Effective tools for reaction work-up Paul A Boguszewski, Alasdair A MacDonald, Aubrey J Mendonca, Frank P Warner | ||
| 163 | Reactivity, selectivity and compatibility: A practical review of polymer supported coupling reagents Paul A Boguszewski, Alasdair A MacDonald, Aubrey J Mendonca, Frank P Warner | ||
| 164 | Structure-activity relationship studies on cyclic peptide-based CXCR4 antagonists: Side-chain and backbone modifications Satoshi Ueda, Shinya Oishi, Zi-xuan Wang, Hiroaki Ohno, Stephen C. Peiper, Nobutaka Fujii | ||
| 165 | Preparation of nucleoside analogs as potential precursors to modified polynucleotides Kamal H. Bouhadir, Nadine Al-Khalil, Manal Farah, Fares A. Fares, Niveen Nasser | ||
| 166 | Synthesis and potency of Sansalvamide A derivatives in pancreatic cancers Suchitra Ravula, Po-Shen Pan, Thomas J. Styers, Rodrigo Rodriguez, Emily Parry, Joseph D. Brown, Erin Singh, Chung-Mao Pan, Kathleen L. McGuire, Shelli R McAlpine | ||
| 167 | Intercalation of C60-carboxymethyl-b-cyclodextrin into magnesium-aluminum layered double hydroxide Annette Medina, Melissa Martínez, Julissa R Gonzalez, Agustín Díaz, Jorge L. Colon | ||
| 168 | Limitations of the PAMPA assay and its role in drug discovery Deborah Galinis-Luciani, Lorrie Nguyen, Mehran Yazdanian | ||
| 169 | Mesoporous silica nanoparticle-based system with double stranded oligonucleotides caps for reversible, controlled release of drugs and genes Juan Luis Vivero-Escoto, Victor S-Y. Lin | ||
| 170 | Total synthesis and biological evaluation of Naamidine A and studies towards spiroleucettadine Nicholas S. Aberle, Guillaume Lessene, Francesca Walker, Keith G. Watson | ||
| 171 | Pharmacophore design on the base of molecular recognition principles Michael B. Darkhovskii, Felix S. Dukhovich | ||
| 172 | Multi-gram total syntheses of Zapotin and (±)-Abyssinone II, cancer chemopreventive natural products Arup Maiti, John M. Pezzuto, Muriel Cuendet, Tamara Kondratyuk, Vicki L. Croy, Mark Cushman | ||
| 173 | Targeting protein kinase C (PKC) to specific cellular membrane domains with the use of DAG-lactones containing rigid oligo(p-phenylene ethynylene) acyl units Dina M. Sigano, Krishnan Malolanarasimhan, Noemi Kedei, Nancy E. Lewin, Peter M. Blumberg, Victor E. Marquez | ||
| 174 | Design and development of new and efficient linkers for tumor-targeting drug delivery Jin Chen, Xianrui Zhao, Shuyi Chen, Jennifer Curato, Robert Rutigliano, Dafna Bar-Sagi, Iwao Ojima | ||
| 175 | The design and synthesis of some novel bisphosphonates as potent inhibitors of farnesyl diphosphate synthase Yonghui Zhang, Fenglin Yin, Rong Cao, Annette Leon-Rossell, Eric Oldfield | ||
| 176 | Parallel synthesis and high-throughput solubility determination of NCGC produced libraries: Models for probe development Michael E. Nelson, Janak K. Padia, Karina M. Zuck, James Inglese, Christopher P. Austin | ||
| 177 | Activation of gene expression in living cells by a synthetic transcription factor mimic Xiangshu Xiao, Peng Yu, Hyun-Suk Lim, Thomas Kodadek | ||
| 178 | Two approaches to synthesis of aryl sulfonyl chloride intermediate for Apratastat TMI-005 Joseph Zeldis, Lalitha Krishnan, T. Z. Wang, David Blum | ||
| 179 | Site-directed mutagenesis of the C1b domain of protein kinase C (PKC) delta provides a unique platform for the development of selective ligands for the atypical PKC zeta Ji-Hye Kang, Megan L. Peach, Yongmei Pu, Peter M. Blumberg, Victor E. Marquez | ||
| 180 | Effects of cyclization constraints on helix/turn peptide structures Renée L. Beyer, Huy N. Hoang, Giang T. Le, David P. Fairlie | ||
| 181 | Alpha helix induction in HIV REV34-50 by N-terminal nucleators Renée L. Beyer, Michael J. Kelso, Robert C. Reid, Giang T. Le, David P. Fairlie | ||
| 182 | Reduction of aldehydes and ketones using solid supported borohydride and microwave heating Panagiotis Ioannidis, Ronny Lundin, Pino Pilotti | ||
| 183 | New paradigm for high throughput preparative HPLC columns Peter C Rahn, Tivadar Farcas, Gareth Friedlander, Joshua Heng, Emmet Welch | ||
| 184 | Compound enumeration in chemical patents Mark R. Hansen, Richard JD Rouse, Hugo O. Villar | ||
| 185 | Sugar-coated nanobiotics Sampath C. Abeylath | ||
| 186 | Intercalation of fulleropyrrolidines into zirconium phosphate layers for drug delivery applications Melissa Martinez, Annette Medina, Agustín Díaz, Jorge L. Colon | ||
| 187 | Potent and selective 3-amino-1-cyclopentanecarboxamide CCR2 antagonists Lihu Yang, Richard X. Jiao, Chris Moyes, Greg Morriello, Gabor Butora, K. Shankaran, Alexander Pasternak, Steve Goble, Changyou Zhou, Malcolm MacCoss, Anne-Marie Cumiskey, Larry Peterson, Mike Forrest, Pasquale P. Vicario, Julia M. Ayala, Hong Jin, Margaret A. Cascieri, Mary Struthers, Julie MeMartino, Sander G. Mills | ||
| 188 | Conformational studies of 3-amino-1-alkyl-cyclopentane carboxamide CCR2 agonists leading to new spirocyclic antagonists Alexander Pasternak, Steve Goble, Gabor Butora, George A. Doss, Nancy N. Tsou, Pasquale P. Vicario, Julia M. Ayala, Julie A. DeMartino, Sander G. Mills, Lihu Yang | ||
| 189 | 3-Amino-1-alkyl-cyclopentane carboxamides as small molecule antagonists of the human and murine CC chemokine receptor Gabor Butora, Richard X. Jiao, William H. Parsons, Pasquale P. Vicario, Jin Hong, Julia M. Ayala, Margaret A. Cascieri, Lihu Yang | ||
| 190 | Discovery of Fms/Kit kinase inhibitors for the treatment of rheumatoid arthritis Ryan Bremer, Jiazhong Zhang, Guoxian Wu, Yong Zhou, Angela Oh, Rafe Shellooe, Ivana Cheung, Kevin Eng, Betsy Burton, Catherine Luu, Marika Nespi, Hongyao Zhu, Maryam Tabrizizad, Julie De Joya-Rice, Kam Zhang, Clarence Hurt, Wayne Spevak, Rebecca Zuckerman, Weiru Wang, Chao Zhang, Ben Powell, Gaston Habets, Brian West, Gideon Bollag, D. Rick Artis, Prabha Ibrahim | ||
| 191 | Design, synthesis and study of new lipoxin A4 analogs Nicos A. Petasis, Kalyan C. Nagulapalli, Raquel Keledjian, Rong Yang, Yee-Ping Sun, Charles N. Serhan | ||
| 192 | Synthesis and biological evaluation of phenylazo benzenesulfonamides as selective COX-2 inhibitors Shwu-Jiuan Lin, Li-Ming Yang | ||
| 193 | 5-Heteroatom substituted pyrazoles as canine COX-2 inhibitors: Synthesis, SAR and molecular modeling studies on binding contribution of 1-(5-methylsulfonyl)pyrid-2-yl and 4-nitrile Subas M. Sakya, Xinjun Hou, Martha L. Minich, Bryson Rast, Andrei Shavnya, Kristin M. L. DeMello, Hengmiao Cheng, Jin Li, Burton H. Jaynes, Donald W. Mann, Carol F. Petras, Scott B. Seibel, Suzanne St. Denis, Michelle L. Haven, Michael P. Lynch | ||
| 194 | 1H-Pyrrole-2,5-dione derivatives as novel COX-2 inhibitors Ji Y. Jeon, Kyung-J. Yun, Kyung-T. Lee, Jae Yeol Lee | ||
| 195 | Structural requirements for time-dependent and time-independent inhibition of prostaglandin synthase I (COX I) Gianmarc G. Johns, Amanda E. Conway, Barry S. Selinsky | ||
| 196 | Discovery of novel, potent, and orally bioavailable STAT6 inhibitors Shinya Nagashima, Hiroshi Nagata, Masahiro Iwata, Masaki Yokota, Hiroyuki Moritomo, Sadao Kuromitsu, Keiko Ohga, Makoto Takeuchi, Shin-ichi Tsukamoto, Mitsuaki Ohta | ||
| 197 | Quinol-4-ones as dissociated non-steroidal glucocorticoid A-ring mimetics Renee M. Zindell, John Regan, Thomas Lee, Younes Bekkali, Joerg Bentzien, Abdelhakim Hammach, Tom Kirrane, Daniel Kuzmich, John Proudfoot, Mark Ralph, Alison Capolino, Richard Nelson, Donald Souza, Dianne Thome, Gerald H. Nabozny, David Thomson | ||
| 198 | A high throughput, automated chemistry approach to the lead optimization of novel P38 MAP kinase inhibitors derived from 1,4-disubstituted naphthalenes Hui Wu, Mark A. Ashwell, Yanbin Liu, Syed M. Ali, Jason Hill, Woj Wrona | ||
| 199 | Applying fragment based drug discovery: p38, a case study Frank P. Hollinger, Zenon Konteatis, Jennifer L. Ludington, Michael Karpusas, Kristofer K. Moffett, Dan Nguyen, Michael S. Saporito, Katrina Northrop, Xiaomei Chai, Marina Bukhtiyarova, Matthew Clark, Frank Guarnieri, Enrique L. Michelotti, Eric Springman | ||
| 200 | Alkyne-quinuclidine derivatives as potent and selective muscarinic antagonists for the treatment of COPD Laurent Provins, Michel Guyaux, Joel Mercier, Bernard Christophe, Michel Gillard, Sophie Jadot, Patrick Lo Brutto, Luc Quéré, Jean-Philippe Starck, Patrice Talaga | ||
| 201 | Synthesis of 1,3,4-thiadiazole and 1,3,4-oxadiazole containing butanoic acids as potent and selective αvβ3 integrin receptor antagonists John A. Wendt, Heather G. Stenmark, Mark L. Boys, Lori Schretzman, Thomas D. Penning, Mark A. Russell, V. Wayne Engleman, Sandra K. Freeman, Melanie L. Hanneke, Marissa Westlin, Tiffany Duffin, Mary Beth Finn, Jeffery L. Keene, Kristen E. Shannon, Christina N. Steininger, Maureen A. Nickols, Jon A. Klover, William Westlin, G. Allen Nickols | ||
| 202 | 2,5-Disubstituted pyrrolidine carboxylates as potent, orally active sphingosine-1-phosphate (S1P) receptor agonists Vincent J Colandrea, Irene E Legiec, Pei Huo, Lin Yan, Jeffrey J. Hale, Sander G. Mills, James Bergstrom, Deborah Card, Gary Chrebet, Richard Hajdu, Carol Ann Keohane, James Milligan, Mark Rosenbach, Gan-Ju Shei, Suzanne Mandala | ||
| 203 | Selective S1P1 receptor antagonist: Synthesis and its in vivo effects Sheng-Kai Wang, M. Germana Sanna, Yu-Hsien Chen, Pedro J. Gonzalez-Cabrera, Anthony Don, David Marsolais, Hugh Rosen, Chi-Huey Wong | ||
| 204 | Discovery, design and SAR studies of 1,2,4-oxadiazole based highly potent S1P1 receptor agonists with exceptional selectivity against S1P2 and S1P3 Zhen Li | ||
| 205 | Synthesis of the immunoproteasome catalytic subunit LMP2-specific modulators Abby Ho, Kyung-Bo Kim | ||
| 206 | Caffeic acid phenethyl ester blocks allergic reaction in mouse model Sae-Gwang Park, Da-Young Lee, In-Hak Choi, Su-Kil Seo, Soo-Woong Lee, Won-Kyo Jung, Se-Kwon Kim, Il-Whan Choi | ||
| 207 | Discovery of novel, orally available piperidine-containing CCR1 antagonists Shou-Fu Lu, Yuo-Ling Chou, Wheeseong Lee, Xiaolin Liang, Gary B. Phillips, Sabine Schlyer, Robert G. Wei, Jinlou Xu, Hongyi Yu, Xue Snow Ge, Paymann Harirchian, Sofia Ribeiro, Babu Subramanyam, Janette Walters, Richard Horuk, Monica J. Kochanny | ||
| 208 | Paper Withdrawn | ||
| 209 | Studies on Bruton's tyrosine kinase, a target for rheumatoid arthritis Zhengying Pan, Heleen Scheerens, Jonathan Li, Brian E Schultz, Paul A Sprengeler, Michael D Sweeney, Paul Grothaus, Douglas A Jeffery, Peter R Young, James T Palmer, Stacie A. Dalrymple | ||
| 210 | TACE inhibitors for RA Chunchun Zhang, Jeremy I. Levin, Frank E. Lovering, Mark Behnke, Kaapjoo Park, LinHong Sun, Yi Zhu, Yuhua Zhang | ||
| 211 | Paper Withdrawn | ||
| 212 | Inhibitors of Tpl2 kinase: An approach towards treatment of RA Junjun Wu, Rajeev Hotchandani, Adrian Huang, Yonghan Hu, Satenig Guler, Huan-Qui Li, Lin-Ling Lin, Steve Tam, Neal Green | ||
| 213 | 1,3,5-Triazine derivatives as protein A mimetics for the treatment of autoimmune diseases Boulos Zacharie, Nicole Wilb, Shaun D. Abbott, Jean-François Bienvenu, Alan Cameron, Josée Cloutier, Jean-Simon Duceppe, Abdallah Ezzitouni, Daniel Fortin, Jean-Hugues Fournier, Karine Houde, Caroline Lauzon, Joël Lechasseur, Nancie Moreau, Valérie Perron, Michel Asselin, Marie-Ève Fafard, Dannyck Gaudreau, Lilianne Geerts, Brigitte Grouix, François Sarra-Bournet, Natalie St-Amant, Lyne Gagnon, Christopher Penney | ||
| 214 | Arylaminoethyl succinamides as a novel series of noncovalent Cathepsin S inhibitors Arnab K. Chatterjee, Hong Liu, David C Tully, Jianhua Guo, Robert Epple, Ross Russo, Jennifer A Williams, Glen Spraggon, Badry D. Bursulaya, Thomas Hollenbeck, Perry Gordon, Tove Tuntland, Jonathan Chang, Jun Li, Jennifer L. Harris | ||
| 215 | Potent and selective semicarbazide-sensitive amine oxidase (SSAO) inhibitors with anti-inflammatory activity Eric Y Wang, Hongfeng Gao, Mary MacDonald, David S Jones, Huong-Thu Ton-Nu, Anne O'Rourke, Luisa Salter-Cid, Li Huang, Andrew Miller, Matthew D Linnik | ||
| 216 | Design and synthesis of small molecule TLR7 and TLR8 immune response modifiers: Investigation of novel A-ring substituted imidazo[4,5-c]quinolines Michael J. Rice, Bryon A. Merrill, David S. Hays, Shri Niwas, Michael E. Danielson, Joshua R. Wurst, Gregory D. Lundquist, Chad A. Haraldson, John F. Gerster, Philip D. Heppner, Tushar A. Kshirsagar, Sarah C. Johannessen, Maureen A. Kavanagh, Kyle J. Lindstrom, Ryan B. Prince, David T. Amos, Matthew R. Radmer, David J. Squire, Scott E. Langer, John R. Jacobsen, Jason D. Bonk, Jason C. Anderson, Sarah A. Strong, Steven A. Van Keuren, Lindsay R. Wurst, Sheila J. Gibson | ||
| 217 | Novel heterocyclic TLR7 and TLR8 immune response modifiers: Design and synthesis of cytokine-inducing 2H-pyrazolo[3,4-c]quinolin-4-amines David S. Hays, Michael E. Danielson, Chad A. Haraldson, Shri Niwas, John F. Gerster, Jason D. Bonk, Sonja J. Mackey, Kyle J. Lindstrom, Ryan B. Prince, Joan T. Moseman, Gregory D. Lundquist, Maureen A. Kavanagh, Tushar A. Kshirsagar, Philip D. Heppner, William H. Moser, Michael J. Rice, Joshua R. Wurst, Sarah J. Spessard, Matthew R. Radmer, Sarah A. Strong, David T. Amos, Daniel J. Willie, Lindsay R. Wurst, Sheila J. Gibson | ||
| 218 | Synthesis and SAR of TLR7 and TLR8 small molecule immune response modifiers: Novel alkylamino and alkoxy functionalized imidazo[4,5-c]quinolines Larry R. Krepski, Karl J. Manske, George W. Griesgraber, Daniel E. Duffy, Joan T. Moseman, Luke T. Dressel, Doris Stoermer, Philip D. Heppner, Tushar A. Kshirsagar, Joseph F. Dellaria, Sheila J. Gibson, Lindsay R. Wurst | ||
| 219 | Design and synthesis of small molecule TLR7 and TLR8 immune response modifiers (IRMs): The preparation and biological evaluation of oxazino[4',3':1,2]imidazo[4,5-c]quinolines George W. Griesgraber, Michael J. Rice, Sarah C. Johannessen, Tushar A. Kshirsagar, Michael E. Danielson, Peter V. Maye, John F. Gerster, Kyle J. Lindstrom, Azim C. Celebi, Michael J. Reiter, Lindsay R. Wurst, Sheila J. Gibson | ||
| 220 | Structure-activity relationships of inhibitors of microsomal prostaglandin E2 synthase derived from MK-886 Hélène Juteau, Yves Gareau, Sébastien Laliberté, Erich L. Grimm, Marc Blouin, Renee Aspiotis, D. Bruce Mackay, Rick W. Friesen, Diane Ethier, Joseph A. Mancini, Nathalie Methot, Joel Rubin, Jocelyne Guay, Sebastien Guiral, Denis Riendeau | ||
| 221 | Structure-activity relationships of inhibitors of microsomal prostaglandin E2 synthase identified from high-throughput screening Tom Y-H. Wu, Hélène Juteau, Sebastien Guiral, Lynn Dufresne, Hugo Poirier, Yves Ducharme, Richard W. Friesen | ||
| 222 | Anti-sepsis compounds: Design, synthesis, and endotoxin-sequestering activities of novel lipopolyamine analogs Sunil A. David, Anurupa Shrestha, Diptesh Sil, Ashok Adisechan, Apurba Datta, Thuan B. Nguyen, Matthew R. Kimbrell, Rajalakshmi Balakrishna | ||
| 223 | Design and synthesis of antiviral Ceragenins Xinzhong Lai, Dianliang Geng, Derya Unumatz, Scott VanCompernolle, Paul B. Savage | ||
| 224 | Pyrroloquinolines as human cytomegalovirus polymerase inhibitors: SAR of arylethanolamine side-chain at C-8 Sajiv K. Nair, Brenda L. Schultz, James A. Nieman, Steven E. Heasley, Valerie A. Vaillancourt, Carolyn A. Brammer | ||
| 225 | Modifications of C-2 on the pyrroloquinoline template aimed at the development of potent herpesvirus antivirals James A. Nieman, Steven E. Heasley, Sajiv K. Nair, Brenda L. Schultz, Herbert M. Zerth | ||
| 226 | Isoindolylureas a new group of antiviral compounds Manjusha Verma, Krishna Nand Singh | ||
| 227 | Synthesis, anti-HIV and CD4 Down-modulation activities of novel CADA compounds Thomas W. Bell, Sreenivasa Anugu, Noah Duffy, Kurt Vermeire, Dominique Schols | ||
| 228 | Synthesis and structure activity relationship of the first inverse agonists for the constitutively active viral-encoded receptor US28 Janneke W. Hulshof, Henry F. Vischer, Mark H. P. Verheij, Martine J. Smit, Iwan J. P. de Esch, Rob Leurs | ||
| 229 | Tight-binding fluorinated inhibitors of viral neuraminidase Ahamindra Jain, Alexander D. Huters, Adam Weinstein, Daniel K. Kwan, Nisha Sandesara | ||
| 230 | Identification of a novel series of NNRTIs with broad antiviral potency against mutant genotypes associated with treatment failure Serge R. Landry, Ma'an H. Amad, Pierre R. Bonneau, Josée Bordeleau, René Coulombe, Patrick L. DeRoy, Louise Doyon, Jianmin Duan, Anne-Marie Faucher, Alexandre Gagnon, Chantal Grand-Maître, Ingrid Guse, Araz Jakalian, Éric Jolicoeur, Steven R. Laplante, Éric Malenfant, Sébastien Morin, Julie Naud, Jeff A. O'Meara, Bruno Simoneau, Bounkham Thavonekham, Kimberley Thompson, Christiane Yoakim, Michael Boes, Michael G. Cordingley | ||
| 231 | Synthesis of 2-bromo-6-octylamino-1-β-D-ribofuranosylimidazo[4,5-e][1,3]diazepine-4,8-dione: A Ring-expanded nucleoside analog with a therapeutic promise against Flaviviridae Peng Zhang, Ning Zhang, Ramachandra S. Hosmane | ||
| 232 | Synthesis and biological evaluation of a novel series of benzothiadiazines as hepatitis C virus RNA-dependent RNA polymerase inhibitors Peggy P. Huang, John T. Randolph, Larry L. Klein, Debra A. Montgomery, Sherie V. Masse, Warren M. Kati, Hongmei Mo, Kent D. Stewart, David WA Beno, Dale J. Kempf | ||
| 233 | In vitro and in vivo activity of 2'-O-alkyl-4'-thio modified antisense oligonucleotides Thazha P. Prakash, Prasad Dande, Andrew M. Siwkowski, Sam Lee, Hans J. Gaus, Eric E. Swayze, Balkrishen Bhat | ||
| 234 | Synthesis of 2'-deoxy-2'-fluoro-2'-C-methylcytidine from uridine as a potent hepatitis C virus inhibitor Peiyuan Wang, Wojciech J. Stec, Michael J. Otto, Kyoichi A. Watanabe | ||
| 235 | L-3,6-dioxa-[3.2.0]bicyclonucleosides: Synthesis and biological evaluation Xingang Fang, Raymond F. Schinazi, Dennis C. Liotta | ||
| 236 | Synthesis and anti-HCV activity of 4'-substituted nucleosides Mark Smith, Joesph Martin, Dave Smith, Hans Maag, Isabel Naiera, Wen-Rong Jiang, Klaus Klumpp, Vincent Leveque, Nick Cammack, Nils Gunnar Johansson, Genadiy Kalayanov, Anna-Karin Belfrage, Kurt Benkestock, Kevin Farnell, Steven Hiscock, Björn Lindborg, Tatiana Maltseva, Veronique Morisson, Pedro Pinho, Christian Sund, Matt Tozer, Anna Winquist, Xiao-Xiong Zhou | ||
| 237 | Gem-dialkyl dihydronaphthylene-1, 3-dione benzothiadiazine derivatives as potent inhibitors of hepatitis C NS5B polymerase Douglas K. Hutchinson, David W. A. Beno, Todd D. Bosse, Wenping He, Wen W. Jiang, Warren M. Kati, Larry L. Klein, William Kohlbrenner, Daniel P. Larson, Yaya Liu, Sherie V. Masse, Tim Middleton, Akhteruzzaman Molla, Debra A. Montgomery, Teresa Rosenberg, Kent D. Stewart, Vincent S. Stoll, Dale J. Kempf | ||
| 238 | Tertiary amine derivatives of 4,4-dialkyl-4H-naphthalene-1,3-dione-substituted benzothiadiazine inhibitors of hepatitis C NS5B polymerase John T Randolph, Charles A Flentge, Peggy P Huang, Larry L Klein, Debra A Montgomery, Sherie V Masse, Warren M Kati, Hongmei Mo, Kent D Stewart, David W A Beno, Dale J Kempf | ||
| 239 | Inhibitors of HCV NS5B polymerase: Synthesis and structure-activity relationships of unsymmetrical 1-hydroxy-4,4-dialkyl-3-oxo-3,4-dihydronaphthylene benzothiadiazine derivatives A. Chris Krueger, Darold L. Madigan, Todd D. Bosse, Wen W. Jiang, Warren M. Kati, Daniel P. Larson, Yaya Liu, Clarence J. Maring, Sherie Masse, Tim Middleton, Hongmei Mo, Akhteruzzaman Molla, Debra Montgomery, Dale J. Kempf | ||
| 240 | Discovery of VP19744: A pyrano[3,4-b]indole-based inhibitor of HCV NS5B polymerase demonstrating in vivo antiviral activity Matthew G. LaPorte, Randy W. Jackson, Christopher J. Burns, Tandy L. Draper, Janet A. Gaboury, Kristin Galie, Torsten Herbertz, Alison R. Hussey, Susan R. Rippin, Christopher A. Benetatos, Srinivas K. Chunduru, Dorothy C. Young, Joel S. Christiansen, Glen A. Coburn, Christopher J. Rizzo, Marc S. Collett, Daniel C. Pevear, Stephen M. Condon | ||
| 241 | Synthesis and structure-activity relationship studies of benzimidazole and related compounds as hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitors Takahiro Oka, Shintaro Hirashima, Kazutaka Ikegashira, Satoru Noji, Hiroshi Yamanaka, Yoshinori Hara, Tomio Ishida, Takayoshi Suzuki, Shinji Yata, Izuru Ando, Satoru Ikeda, Hiromasa Hashimoto | ||
| 242 | Discovery and design of potent piperidine-based CCR5 antagonists for the potential treatment of HIV-1 infection Brian A. Chauder, Donald Anderson, Christopher J. Aquino, Neil Bifulco, Lawrence R. Boone, Eric E. Boros, Pek Y. Chong, Kien S. Du, Maosheng Duan, Robert G. Ferris, Wieslaw M. Kazmierski, Terrence P. Kenakin, Cecilia S. Koble, Daniel G. Lang, Jennifer P. Peckham, Andrew Spaltenstein, James B. Thompson, Michael K. Youngman, Patricia J. Wheelan | ||
| 243 | Hydrazone amides as novel peptoid surrogates for expedited library synthesis: Application to the preparation of TSG101-directed HIV-1 budding antagonists Fa Liu, Andrew G. Stephen, Catherine Adamson, Eric O. Freed, Robert J. Fisher, Terrence R. Burke Jr. | ||
| 244 | Design, synthesis and antiviral activity of cyclobutyl phosphonate nucleoside analogs as chain terminators against HIV Yongfeng Li, Raymond F. Schinazi, Dennis C. Liotta | ||
| 245 | Design and discovery of second generation HIV-1 integrase inhibitors as anti-HIV/AIDS agents Raveendra Dayam, Tino Sanchez, Laith Q Al-Mawsawi, Nouri Neamati | ||
| 246 | Virtual screening application of a model of full-length HIV-1 integrase complexed with viral DNA Iwona E Weidlich, Rajeshri G. Karki, Marc C. Nicklaus | ||
| 247 | Bicyclic pyrimidones as inhibitors of HIV-integrase Benedetta Crescenzi, Cristina Gardelli, Monica Donghi, Marco Ferrara, Paola Pace, Olaf Kinzel, Ester Muraglia, Michael Rowley, Ralph Laufer, Fabrizio Fiore, Odalys Gonzalez Paz, Massimiliano Fonsi, Kara A. Stillmock, Marc V. Witmer, Daria J. Hazuda, Vincenzo Summa | ||
| 248 | Click chemistry-derived biotin-tagged diketo acid-containing biphenyl ketones designed as HIV-1 integrase photoaffinity ligands Xue Zhi Zhao, Elena A. Semenova, Allison Johnson, Christophe Marchand, Chenzhong Liao, Marc C Nicklaus, Yves Pommier, Terrence R Burke Jr. | ||
| 249 | Novel HIV-1 integrase inhibitors: 8-Hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-ones Boyoung Kim, Thorsten E. Fisher, Terry A. Lyle, Steven D. Young, Joseph P. Vacca, Daria J. Hazuda, Peter J. Felock, William A. Schleif, Lori Gabryelski, John S. Wai | ||
| 250 | Design and synthesis of substituted 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamides, novel HIV-1 integrase inhibitors H. Marie Moritz, Peter Williams, John S. Wai, Janetta M. Dewhurst, Terry A. Lyle, Carl F. Homnick, Joseph P. Vacca, Daria J. Hazuda, Peter J. Felock, Kara A. Stillmock, William A. Schleif, Lori J. Gabryelski | ||
| 251 | Synthesis and biological activity of L-chicoric acid analogs as HIV-1 integrase inhibitors Xiangyang Lei, Charles G. Gibbs, Manfred G. Reinecke, W. Edward Robinson Jr. | ||
| 252 | Synthesis and activity of thiadiazines as HCV polymerase inhibitors Keith F. McDaniel, Allan C. Krueger, David A. Betebenner, Pamela L. Donner, Brian E. Green, Darold L. Madigan, Clarence J. Maring, Debra A. Montgomery, Tim R. Middleton, Warren M. Kati, Gennadiy Koev, Wen W. Jiang, Yaya Liu, Hongmei Mo | ||
| 253 | Development of QPLD (QM-polarized ligand docking) Art E. Cho, Ramy Farid, Richard Friesner | ||
| 254 | Norcysteine (α-thiolglycine), a versatile scaffold to tailor structure and activity of peptides Manoj P. Samant, Doley J. Hong, Glenn Croston, Jean E. Rivier | ||
| 255 | Development of a new cancer screening method by comprehensive 2D gas chromatography/time-of-flight mass spectrometry (GCxGC/TOF MS) J. M. D. Dimandja, I Enwerem | ||
| 256 | Protein-binding agents based on the supramolecular self-assembly of oligonucleotide-linked organic fragments Andrew Hamilton, Debarati M. Tagore, Katherine I Sprinz, Steven Fletcher | ||
| 257 | Chemical validation of novel hydrogenation, ozonolysis, and high pressure microfluidic reactors as new tools for medicinal synthetic chemistry Richard Jones, Ferenc Darvas, Csaba Csajagi | ||
| 258 | Pattern analysis using NMR spectroscopy (PANSY): Applications to organic and pharmaceutical chemistry Ruben M. Savizky, John L. Bove, Zhen Y. Liu | ||
| 259 | Synthesis of selectively protected spirostane-2,3-diol stereoisomers Katharine L. Bowdy, Branko S. Jursic | ||
| 260 | The metal-complexation properties of cytotoxic tripodal hexadentate chelators: Effects of heterocycle donor arms on Fe(II) chelation and fibroblast IC50 value Roy P. Planalp, Giang Lu, Daniel P Kennedy, Martin W. Brechbiel, Robin D. Rogers, Rong Ma, Frank M. Torti, Suzy V. Torti | ||
| 261 | Photogenerated bases for parallel microarray synthesis using Fmoc-chemistry Wu Yao, Xiaolian Gao, Ailing Hong, Xiaochuan Zhou, Erdogan Gulari | ||
Symposium Grid -- Division of Medicinal Chemistry -- Session Listing
Symposium Grid -- Drug Discovery -- Session Listing
The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006