MEDISunday, 10 September 2006
9:00 AM-12:40 PM Moscone Center -- Room 102, Oral
General Oral Session
Organizer:David P. Rotella
9:00 AM1Structure-activity relationship study of tricyclic necroptosis inhibitors
Prakash Jagtap, Alexei Degterev, Sungwoon Choi, Junying Yuan, Gregory D Cuny
9:20 AM2Tamoxifen, diethylstilbestrol and other non-steroidal estrogens, a novel class of store operated calcium channel modulators that affect platelet activation and thrombosis: Two faces of one pharmacophore
Yuliya Dobrydneva, Ross Weatherman, Joseph Trebley, Megan Fitzgerald, Sonia Antony, Nithiananda Chatterjie, Peter Blackmore
9:40 AM3Discovery and optimization of novel, nonsteroidal glucorticoid receptor modulators
David E. Clark, Nicholas C. Ray, Hazel J. Dyke, H. Gwen Hickin, Karen Williams, Peter H. Crackett, Peter M. Lockey, Melanie Wong, Soraya Porres, Anne White, Robin D. Clark, Joseph K. Belanoff
10:00 AM4Discovery of cyclohexene-constrained phenethylamine, ABT-341: A highly potent, selective, safe and orally available dipeptidyl peptidase IV inhibitor for the treatment of Type 2 diabetes
Zhonghua Pei, Xiaofeng Li, Thomas W. von Geldern, David J. Madar, Kenton Longenecker, Yong Hong, Bradley A. Zinker, Thomas H. Lubben, Kent D. Stewart, Bradley J. Backes, Michael A. Stashko, Stephen J. Ballaron, David W. A. Beno, Amanda K. Mika, Glenn A. Reinhart, Ryan M. Fryer, Lee C. Preusser, Anita J. Kempf-Grote, Hing L. Sham, James M. Trevillyan
10:20 AM5Metabolism driven pharmacokinetic optimization of dual inhibitors of Angiotensin 1 and Endothelin A receptors
William R Ewing, Natesan Murugesan, Zhengxiang Gu, Leena Fadnis, Yeheng Zhu, Guixue Yu, Xiamo Wu, Lyndon Cornelius, Helen Mason, Robert Zahler, Donglu Zhang, Susan Authur, Rose Ann Baska, Hossain Monshizadegan, Carol Ryan, Kenneth Carlson, Mark Kowala, Celia D'Arienzo, Hongjian Zhang, William G. Humphreys, John E. Macor
10:40 AM6Discovery of potent, water soluble CB1 receptor agonists
Julia M. Adam
11:00 AM7Design, structure-activity relationships and biological evaluation of novel bifunctional C-terminal modified peptides for opioid receptor agonists and Neurokinin-1 receptor antagonists
Takashi Yamamoto, Padma Nair, Shou-wu Ma, Sharif Moye, Tally Largent, Todd W. Vanderah, Josephine Lai, Frank Porreca, Henry I. Yamamura, Victor J. Hruby
11:20 AM8Structure activity relationships of novel non-competitive mGluR-1 antagonists: A potential treatment for nociceptive pain
Dafydd R. Owen
11:40 AM9Development of nocaine/modafinil hybrid monoamine transporter inhibitors as superior antidepressants: From compound library establishment to in vivo evaluation
Jia Zhou, Kenneth M. Johnson, Kelly M. Giberson, Paul McGonigle, Barbara J. Caldarone, Alan P. Kozikowski
12:00 PM10Synthesis and structure-activity relationships of 4-hydroxy-4-phenyl- and spiropiperidines as nociceptin receptor ligands
Ginny D Ho, Ana Bercovici, John Caldwell, Ahmad Fawzi, Julius Matasi, April Smith Torhan, Deen Tulshian, Hongtao Zhang
12:20 PM11Design, synthesis and structure-activity relationship of N(1)-(2-phenyl-cylohexyl)-4-amino-piperidine derivatives as potent and selective glycine reuptake inhibitors
Simona M Ceccarelli, E. Pinard, Henri Stalder, Daniela Alberati

Symposium Grid -- Division of Medicinal Chemistry -- Session Listing

Symposium Grid -- Drug Discovery -- Session Listing

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006