TOXITuesday, 12 September 2006

8:00 AM-12:00 PM Moscone Center -- Room 308, Oral
General Papers: Young Investigator Session
Organizer:Trevor Martin Penning
8:00 AMSolution structures of the food mutagen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in the recognition sequence of the NarI restriction enzyme: Sequence context effect
Feng Wang, C. Eric Elmquist, James S. Stover, Carmelo J. Rizzo, Micheal P. Stone
8:15 AMCharacterization and quantitation of 2'-deoxyguanosine adducts of the dietary carcinogen PhIP by linear quadrupole ion trap mass spectrometry
Angela K. Goodenough, Robert J. Turesky
8:30 AMSynthesis and site-specific incorporation of 2,6-diamino-4-hydroxy-N5-(methyl)-formamidopyrimidine (Me-FAPy) adduct into oligonucleotides
Plamen P. Christov, Ivan D. Kozekov, Kyle L. Brown, Michael P. Stone, Thomas M. Harris, Carmelo J. Rizzo
8:45 AMBenzo[a]pyrene-mediated DNA-adduct formation in bronchoalveolar cells
Stacy Lynn Gelhaus, Qian Ruan, Seon Hwa Lee, Trevor M Penning, Ian A. Blair
9:00 AMTranslesion synthesis by Sulfolobus solfataricus DNA polymerase Dpo4 across polycyclic aromatic hydrocarbon diol epoxide adducts of deoxyadenosine
Goutam Chowdhury, Hong Zang, Karen C. Angel, Thomas M Harris, F. Peter Guengerich
9:15 AMFormation and accumulation of pyridyloxobutyl (POB)-DNA adducts in F344 rats treated with tobacco-specific carcinogens
Yanbin Lao, Nanxiong Yu, Fekadu Kassie, Stephen S. Hecht
9:30 AMRole of electrostatic interactions in the unusual selectivity of nitrosoperoxycarbonate for guanines with the highest ionization potentials in DNA
Yelena Margolin, Vladimir Shafirovich, Nicholas E. Geacintov, Peter C. Dedon
9:45 AMReversible DNA alkylation by leinamycin
Sanjay Dutta, Joseph Szekely, Tony Nooner, Kent S. Gates
10:00 AMKinetics of carboplatin-DNA binding in genomic DNA and bladder cancer cells as determined by accelerator mass spectrometry
Sang Soo Hah, Paul T. Henderson
10:15 AMIntermission
10:30 AMUnderstanding the biological activity of S-deoxy leinamycin: Thiol triggered release of H2S from the 1,2-dithiolan-3-one heterocycle
Santhosh Sivaramakrishnan, Kent S Gates
10:45 AMDNA-protein crosslinks induced by bis-functional electrophiles
Elisabeth M. Loecken, Amy Joan L. Ham, D. C. Liebler, F. Peter Guengerich
11:00 AMUVA-induced oxidation of 6-thioguanine in mammalian cells
Chunang Gu, Yinsheng Wang
11:15 AMAmiodarone-induced cytotoxicity: Link to mitochondrial dysfunction and labile iron involvement
Adrian C. Nicolescu, Bruce C. Hill, James F. Brien, William J. Racz, Thomas E. Massey
11:30 AMIn vitro evidence for mechanism based inactivation of P450 2E1 by 1,2-epoxy-3-butene
Gunnar Boysen, Nadia I Georgieva, Cameron O Scarlett, Brenda Temple, Christoph H Borchers, James Swenberg
11:45 AMToxicological and structural features of KIAA1363: A novel detoxifying enzyme for organophosphorus nerve poisons
Daniel K. Nomura, Kathleen A. Durkin, Kyle P. Chiang, Gary B. Quistad, Benjamin F. Cravatt, John E. Casida

Symposium Grid -- Division of Chemical Toxicology -- Session Listing

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006