Characterization of novel benzofuroxans by 1H NMR studies

ANYL 90

Elisa Leyva, elisa@uaslp.mx1, Denisse A. de Loera1, and Rogelio Jimenez2. (1) Department of Chemistry, Universidad Autonoma de San Luis Potosi, Manuel Nava 6, Montes Carpatos 395, San Luis Potosi, 78210, Mexico, (2) Chemistry Department, Universidad Autonoma de San Luis Potosi, Montes Carpatos 395, San Luis Potosi, 78210, Mexico
Furoxans comprise a well-known class of heterocyclic compounds which proved to exhibith a variety of biological activities. The ability of benzofuroxans to be involved in the synthesis of DNA and peptides has stimulated a search aimed at the development of anticancer compounds. Furoxans are also of interest as cardiovascular agents due to their ability to generate nitrous oxide. Substituted and fluorinated benzofuroxans have gained attention in recent years since fluorine atoms are known to increase the ability of organic compounds to penetrate thorough lipid membranes, thus making these molecules more potent as biologically active compounds. 1H NMR studies on the tautomerism of several substituted benzofuroxans is presented. The effect of the substituents on this tautomerism is presented.
 

General Papers
7:00 PM-9:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster

Division of Analytical Chemistry

The 232nd ACS National Meeting, San Francisco, CA, September 10-14, 2006