ANYL 132 |
| As the environment for discovering and developing potent pharmaceuticals becomes more competitive and more costly, companies are looking to identify potential lead compounds earlier in the process. Employing purification methods to facilitate the route to candidate selection is gaining in popularity. Technologies, such as preparative liquid chromatography (LC), have yielded in the isolation of impurities from potential lead molecules. Yet these techniques involve tremendous man hours and consume/generate large volumes of hazardous, liquid waste. An attractive alternative to preparative scale LC is a closely related technology, Supercritical Fluid Chromatography (SFC). The bulk of the mobile phase is carbon dioxide (CO2), which is highly tunable in its chromatographic properties and is easily removed from the collected fraction. Supercritical CO2 also demonstrates lower viscosity than traditional LC solvents, thereby enabling geometric scalability with reduced penalty of back pressure or pressure drop across a column, and follows the basic chromatographic principles understood by most end-users. Thar Technologies implements its core competency of pumping and regulating supercritical carbon dioxide in its chromatographic instrumentation offerings. The objective of this presentation is to spotlight the combined ability to conduct method development and purification on our “Investigator” system. We wish to demonstrate through several applications of the ease of use of the instrument, as well as, demonstrate the economic and environmental attractiveness of the technology. |
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General Papers
7:00 PM-9:00 PM, Sunday, 10 September 2006 Moscone Center -- Hall D, Poster
Division of Analytical Chemistry |